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In order to study the impact of continuous vaccination and voluntary isolation for the COVID-19, a susceptible-exposed-infected-recovered-quarantine-vaccines (SEIR-QV) model is proposed. A basic regeneration number R is defined to determine the extinction or persistence of the disease. We numerically analyze the impact of key parameters based on actual parameters of COVID-19, such as the vaccination rate, population importation rate, and natural (or causal) mortality transmission rate on the dynamics of disease transmission. Then we obtain sensitivity indices of some parameters on 0 is defined to determine the extinction or persistence of the disease. We numerically analyze the impact of key parameters based on actual parameters of COVID-19, such as the vaccination rate, population importation rate, and natural (or causal) mortality transmission rate on the dynamics of disease transmission. Then we obtain sensitivity indices of some parameters on R 0 by sensitivity analysis. Finally, the stability of the system and the effectiveness of the optimal control strategy are verified by numerical simulation., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2022 Yue Yu et al.)

In the detection of COVID-19, chest X-ray (CXR) images and CT scan images are two main technical methods, which provide an important basis for doctors' diagnosis. Currently, convolutional neural network (CNN) in detecting the COVID-19 medical radioactive images has problems of low accuracy, complex algorithms, and inability to mark feature regions. In order to solve these problems, this paper proposes an algorithm combining Grad-CAM color visualization and convolutional neural network (GCCV-CNN). The algorithm can quickly classify lung X-ray images and CT scan images of COVID-19-positive patients, COVID-19-negative patients, general pneumonia patients and healthy people. At the same time, it can quickly locate the critical area in X-ray images and CT images. Finally, the algorithm can get more accurate detection results through the synthesis of deep learning algorithms. In order to verify the effectiveness of the GCCV-CNN algorithm, experiments are performed on three COVID-19-positive patient datasets and it is compared with existing algorithms. The results show that the classification performance of the algorithm is better than the COVID-Net algorithm and the DeTraC-Net algorithm. The GCCV-CNN algorithm achieves a high accuracy of 98.06%, which is faster and more robust.

Based on the SEIR model, which takes into account prevention and control measures, prevention and control awareness, and economic level and medical level indicators, this paper proposes an infectious disease model of "susceptible-exposed-infected-removed-asymptomatic-isolated" (short for SEIR-AQ) to assess and predict the development of the COVID-19 pandemic with different prevention and control strategies. The kinetic parameters of the SEIR-AQ model were obtained by fitting, and the parameters of the SEIR-AQ model were solved through the Euler method. Furthermore, the effects of different countries' prevention and control strategies on the number of infections, the proportion of isolation, the number of deaths, and the number of recoveries were also simulated. The theoretical analysis showed that measures such as isolation for prevention and control and medical tracking isolation had a significant inhibitory effect on the development of the COVID-19 pandemic, among which stratified treatment and enhanced awareness played a key role in the rapid regression of the peak of COVID-19-infected patients. Conclusion of the Simulation. The SEIR-AQ model can be used to evaluate the development status of the COVID-19 epidemic and has some theoretical value for the prediction of COVID-19. [ABSTRACT FROM AUTHOR]

The global outbreak of the COVID-19 epidemic has caused a considerable impact on humans, which expresses the urgency and importance of studying its impacts. Previous studies either frequently use aggregated research methods of statistic data or stay during COVID-19. The afterward impacts of COVID-19 on human behaviors need to be explored further. This article carries out a non-aggregated study methodology in human geography based on big data from social media comments and takes Nanjing, China, as the research case to explore the afterward impact of the COVID-19 epidemic on the spatial behavior of urban tourists. Precisely, we propose the methodology covers two main aspects regarding travel contact trajectory and spatial trajectory. In contact trajectory, we explore three indicators—Connection Strength, Degree Centrality, and Betweenness Centrality—of the collected attractions. Then, in spatial trajectory, we input the results from contact trajectory into ArcGIS by using the Orientation–Destination Model and Standard Deviation Ellipse to explore the influences on the spatial pattern. By setting up comparative groups for the three periods of before, during, and after the COVID-19 in Nanjing, this study found that, in the post-epidemic era, (1) the spatial behavior of urban tourists showed a state of overall contraction; (2) the objects of contraction changed from urban architectural attractions to urban natural attractions; (3) the form of contraction presents concentric circles with the central city (Old City of Nanjing) as the core; (4) the direction of contraction heads to the large-scale natural landscape in the central city, which highlights the importance of green open spaces in the post-epidemic era. [ABSTRACT FROM AUTHOR]