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Objective: The coronavirus disease-2019 (COVID-19) pandemic can increase anxiety and depression in patients with multiple sclerosis (PwMS). This study aimed to evaluate the predictors of anxiety and depression in PwMS during the COVID-19 pandemic and compare it with the general population (GP). Materials and Methods: The study was conducted in an MS clinic in Istanbul University Istanbul Faculty of Medicine. Data were collected online using a form including sociodemographics and questions on COVID-19-related knowledge and the hospital anxiety and depression scale. Results: This study included 800 participants (GP: 421, MS: 379). Anxiety (42.3% vs. 32.2%, p=0.002) and depression (53.9% vs. 39.6%, p