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5 results on '"Possuelo, Lia Gonçalves"'

1. The Omicron Lineages BA.1 and BA.2 ( Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub.

Author

Lamarca AP, Souza UJB, Moreira FRR, Almeida LGP, Menezes MT, Souza AB, Ferreira ACS, Gerber AL, Lima AB, Guimarães APC, Cavalcanti AC, Silva ABPE, Lima BI, Lobato C, Silva CGD, Mendonça CPTB, Queiroz DC, Zauli DAG, Menezes D, Possebon FS, Cardoso FDP, Malta FSV, Braga-Paz I, Silva JDP, Ferreira JGG, Galvão JD, Souza LM, Ferreira L, Possuelo LG, Cavalcante LTF, Alvim LB, Souza LFA, Santos LCGAE, Dias RC, Souza RB, Castro TRY, Valim ARM, Campos FS, Araujo JP Jr, Trindade PA, Aguiar RS, Michael Delai R, and Vasconcelos ATR

Subjects
Humans, Brazil epidemiology, Transportation, Vaccination, SARS-CoV-2 genetics, COVID-19
Abstract

Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA.2 entered and spread in the country by sequencing 2173 new SARS-CoV-2 genomes collected between October 2021 and April 2022 and analyzing them in addition to more than 18,000 publicly available sequences with phylodynamic methods. We registered that Omicron was present in Brazil as early as 16 November 2021 and by January 2022 was already more than 99% of samples. More importantly, we detected that Omicron has been mostly imported through the state of São Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation.

Published
2023
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2. Early introduction, dispersal and evolution of Delta SARS-CoV-2 in Southern Brazil, late predominance of AY.99.2 and AY.101 related lineages.

Author

Gularte JS, da Silva MS, Mosena ACS, Demoliner M, Hansen AW, Filippi M, Pereira VMAG, Heldt FH, Weber MN, de Almeida PR, Hoffmann AT, Valim ARM, Possuelo LG, Fleck JD, and Spilki FR

Subjects
Brazil epidemiology, Humans, Mutation Rate, Phylogeny, COVID-19 epidemiology, COVID-19 virology, SARS-CoV-2 genetics
Abstract

The emergence of Variants of Concern (VOC) presenting an unusual number of new mutations is one of the most remarkable features of SARS-CoV-2. The Delta variant, since its appearance, replaced the VOC Gamma, which was responsible for the major COVID-19 wave in Brazil. In this study, we performed a Delta whole-genome sequencing of 183 samples as part of a major genomic surveillance study performed since the beginning of the pandemic. Here, we showed an emergence, widespread dispersion and consolidation of the Delta variant in Rio Grande do Sul State, completely replacing the Gamma variant in a four to five months period. Performing the phylogenetic and phylodynamic analysis, the majority of the sequences generated herein were classified as AY.99.2, AY.99.2-like and AY.101. AY.99.2 Delta-related lineage has been widely reported in Brazil and in the Americas as well. Altogether, our findings provided a mutational profile of the sequences and presented high substitutions per site in the root-to-tip phylogenetic tree, corroborating studies that show the high mutational rate of SARS-CoV-2 over time., (Copyright © 2022 Elsevier B.V. All rights reserved.)

Published
2022
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4. Predominance of SARS-CoV-2 P.1 (Gamma) lineage inducing the recent COVID-19 wave in southern Brazil and the finding of an additional S: D614A mutation.

Author

Demoliner M, da Silva MS, Gularte JS, Hansen AW, de Almeida PR, Weber MN, Heldt FH, Silveira F, Filippi M, de Abreu Góes Pereira VM, da Silva FP, Mallmann L, Fink P, de Moura Valim AR, Possuelo LG, Fleck JD, and Spilki FR

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Brazil epidemiology, COVID-19 virology, Child, Consensus Sequence, Female, Humans, Male, Middle Aged, Phylogeny, Spike Glycoprotein, Coronavirus chemistry, Spike Glycoprotein, Coronavirus genetics, Whole Genome Sequencing, Young Adult, COVID-19 epidemiology, Mutation, SARS-CoV-2 genetics
Abstract

Recently, the highest wave of SARS-CoV-2 epidemic occurred since the beginning of the pandemic in Brazil was registered in Rio Grande do Sul (RS) State, Southern Brazil, considering the number of cases, deaths and hospitalization per day caused by COVID-19. In this study we described which lineages were circulating in the first quarter of 2021 in Southern Brazil to better understand the viral factors involved in the health crisis caused by SARS-CoV-2 in the region, searching also for possible additional SARS-CoV-2 sequence mutations. A total of 70 positive SARS-CoV-2 samples collected between January 28th, 2021 until April 23rd, 2021, were selected to sequencing. Whole genome sequencing of 70 SARS-CoV-2 samples showed a predominance of Gamma lineage (67%, 47/70), followed by P.2 lineage (27%, 19/70) and B.1.1.28 (6%, 4/70). Two Gamma lineage consensus sequences presented a new S:D614A mutation. Newly mutations could be emerging due the quick SARS-CoV-2 spreading. Thus, the greater understanding about immune protection and variants vigilance is essential to the better management of the health SARS-CoV-2 crisis., (Copyright © 2021. Published by Elsevier B.V.)

Published
2021
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5. La Educación Permanente en Salud y los actores del sistema penitenciario en el escenario pandémico

Author

Ely, Karine Zenatti, Schwarzbold, Pauline, Ely, Gabriela Zenatti, Vendrusculo, Victor Göttems, Dotta, Renata Maria, Rosa, Lutiana Ricaldi da, Krug, Suzane Beatriz Frantz, Valim, Andréia Rosane de Moura, and Possuelo, Lia Gonçalves

Subjects
prisiones, educação em saúde, prisões, investigación cualitativa, Covid-19, educación para la salud, pesquisa qualitativa, prisons, qualitative research, education in health
Abstract

Resumo A Educação Permanente em Saúde legitimou a educação na saúde com base na aprendizagem significativa, em vivências no cotidiano de trabalho e na solução de problemas de forma coletiva, além de estar pautada no Quadrilátero Ensino-Gestão-Atenção-Controle Social. A pandemia da Covid-19 exigiu novas formas de fazer saúde e educação, principalmente no sistema prisional, onde a superlotação é um impeditivo ao isolamento social. Este estudo teve como objetivo identificar, por meio de rodas de conversa virtuais, os desafios encontrados no cotidiano de trabalho e discutir propostas de intervenção com os atores do sistema prisional no período pandêmico, na perspectiva da Educação Permanente em Saúde. Foi utilizada abordagem qualitativa de investigação com caráter descritivo, interpretativo e compreensivo de análise do fenômeno social, por meio da análise de conteúdo temático de Minayo. Da análise temática de conteúdo emergiram quatro categorias: desafios da assistência em saúde no sistema prisional no contexto da pandemia da Covid-19; desafios para a gestão da saúde nos estabelecimentos prisionais; interlocução entre instituições de ensino e sistema prisional; e o controle social e a representação familiar. As rodas de conversa virtuais propiciaram discussões aprofundadas e construções coletivas, propondo encaminhamentos pautados no Quadrilátero da Educação Permanente em Saúde. Abstract Permanent Education in Health legitimized health education based on meaningful learning, experiences in daily work and collective problem solving, in addition to being based on the four-way approach, based on teaching, management, attention and social control. The COVID-19 pandemic has required new ways of doing health and education, especially in the prison system, where overcrowding is an impediment to social isolation. This study aimed to identify, through virtual conversation circles, the challenges encountered in daily work and discuss proposals for intervention with the actors of the prison system in the pandemic period, from the perspective of Permanent Education in Health. It was used a qualitative research approach with descriptive, interpretative and comprehensive analysis of the social phenomenon, through Minayo’s thematic analysis of content. From the thematic analysis of content, four categories emerged: challenges of health care in the prison system in the context of the COVID-19 pandemic; challenges for health management in prisons; dialogue between educational institutions and the prison system; and social control and family representation. The virtual conversation rounds provided in-depth discussions and collective constructions, proposing referrals based on the four-way approach of Permanent Education in Health. Resumen La Educación Permanente en Salud legitimó la educación en salud basada en el aprendizaje significativo, en experiencias en el cotidiano de trabajo y en la resolución colectiva de problemas, además de basarse en el Cuadrilátero Enseñanza-Gestión-Atención-Control Social. La pandemia del Covid-19 requirió nuevas formas de hacer salud y educación, especialmente en el sistema penitenciario, donde el amontonamiento es un impedimento para el aislamiento social. Este estudio tuvo como objetivo identificar, a través de círculos de conversación virtuales, los desafíos encontrados en el trabajo diario y discutir propuestas de intervención con los actores del sistema penitenciario en el período pandémico, en la perspectiva de la Educación Permanente en Salud. Se utilizó un enfoque de investigación cualitativo con un análisis descriptivo, interpretativo y comprensivo del análisis del fenómeno social, a través del análisis de contenido temático de Minayo. Del análisis temático de contenido surgieron cuatro categorías: desafíos de la atención en salud en el sistema penitenciario en el contexto de la pandemia de la Covid-19; desafíos para la gestión de la salud en las cárceles; diálogo entre las instituciones educativas y el sistema penitenciario; y el control social y la representación familiar. Los círculos de conversación virtuales proporcionaron discusiones profundas y construcciones colectivas, proponiendo encaminamientos basados en el Quadrilátero de la Educación Permanente en Salud.

Published
2023

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