22 results on '"Muñoz, Manuel"'
Search Results
2. The Role of the Sense of Belonging During the Alarm Situation and Return to the New Normality of the 2020 Coronavirus Pandemic (COVID-19) in Spain
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Saiz, Jesús, González-Sanguino, Clara, Ausín, Berta, Castellanos, Miguel Ángel, Abad, Ana, Salazar, María, and Muñoz, Manuel
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- 2021
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3. Verificación del desempeño de la prueba rápida 'AMP Rapid Test SARS-CoV-2 IgG/IgM- Cassettes'
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Gil-Villa, Diana María, Sepúlveda-Arias, Juan Carlos, Martinez Muñoz, Manuel Andrés, Zuluaga-Vélez, Augusto, Hoyos-Pulgarin, Julian A., Martínez, Jose W., Giraldo-Montoya, Angela Maria, Valencia-Buitrago, Angélica María, and Sánchez-Duque, Jorge A.
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control de calidad ,antigens ,anticuerpos ,COVID-19 ,antígenos ,serology ,antibodies ,quality control ,serología - Abstract
Resumen Objetivo: Verificación del desempeño de las pruebas serológicas rápidas utilizadas en el departamento de Risaralda, Colombia. Métodos: Estudio analitico, de corte transversal. Incluyó muestras de sueros de trabajadores de la salud de la ciudad de Pereira, quienes tuvieron sospecha clínica y epidemiológica por SARS-CoV-2. El procesamiento y validación de las pruebas fue realizado en las instalaciones de la Universidad Tecnológica de Pereira. Se calculó sensibilidad y especificidad de las pruebas rápidas serológicas IgM/IgG usando como prueba de oro la RT-PCR. Resultados: Se incluyeron las muestras de 144 profesionales de la salud. Las pruebas serológicas rápidas evidenciaron ser útiles para identificar o descartar la presencia de anticuerpos IgM e IgG, especialmente en pacientes sintomáticos, en quienes el inicio de los síntomas es superior a 11 días. Discusión: El uso de pruebas rápidas se encuentra en aumento, no solo por la rapidez de sus resultados, sino también por los bajos costos asociados y la necesidad de identificar pacientes no susceptibles, quienes deben priorizar su retorno a actividades laborales en comunidad como parte de la reactivación económica de Colombia. Es necesario confirmar el desempeño de la prueba para aumentar la probabilidad de una adecuada clasificación antes de proceder a su uso rutinario. Abstract Objective: We aimed to realize a verification of the performance of the rapid serological tests used in Risaralda department. Methods: Analytical, cross-sectional study. Serum samples from health workers in Pereira city, who had a clinical and epidemiological suspicion for SARS-CoV-2 were included. The processing and validation of the tests was carried out at Universidad Tecnológica de Pereira. Sensitivity and specificity of rapid IgM / IgG sero logical tests were calculated using RT-PCR as the gold standard test. Results: 144 samples of health professionals were included. Rapid serological tests useful to identify or rule out the presence of IgM and IgG antibodies, especially in symptomatic patients, in whom the onset of symptoms is longer than 11 days. Discussion: The use of rapid tests is increasing, not only due to the speed of their results, but also due to the low associated costs and the need to identify non-susceptible patients, who must prioritize their return to work activities in the community as part of the economic reactivation of Colombia. It is necessary to confirm the adequate performance of the test to increase the probability of an adequate classification before proceeding with the routine use of this test.
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- 2021
4. Filosofía y Vir(us)tualidad: pensando en contextos de pandemia
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Palacio Muñoz, Manuel Darío, Universidad Nacional Abierta y a Distancia (UNAD), Monroy Gutiérrez, Einar Iván, Correa García, Luis Felipe, Universidad Tecnológica de Pereira, Quijano Restrepo, Luis Guillermo, Villegas Giraldo, Pablo Andrés, López, Juan Manuel, Parra Serna, Diego Fernando, and Rodríguez, Cristian Fabián
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covid-19 ,virtualidad ,pandemia ,filosofía - Abstract
El presente libro es el resultado de una investigación conjunta entre el equipo docente de los programas de filosofía de la UTP (Universidad Tecnológica de Pereira) y de la UNAD (Universidad Nacional Abierta y a Distancia). Así, este volumen es un lugar de encuentro de reflexiones filosóficas desde diferentes perspectivas, que ofrecen una visión amplia de las consecuencias de una “nueva normalidad” en contextos de pandemia. Una confluencia de enfoques diversos permite que este libro sea un referente académico e investigativo en el desarrollo de filosofía aplicada al entorno social, político, económico y académico.A partir del reconocimiento de lo que se pone en juego, con las medidas adoptadas a nivel nacional e internacional ante la crisis por COVID-19, las contribuciones de este libro ofrecen una lectura del fenómeno de la pandemia desde una perspectiva crítica. Por ello, aquí se dan cita revisiones de las estrategias biopolíticas adoptadas por los gobiernos, así como revisiones del lugar de la ética y de la solidaridad. Algunos capítulos abordan el tema de un contractualismo internacional y otros apuestan por un reconocimiento de nuevas “normalidades” y “anormalidades”. Todas estas revisiones críticas permiten un desarrollo del pensamiento, que rompen las ilusiones que bloquean los caminos de un pensar emancipador.
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- 2021
5. Impacto del Covid-19 en la salud mental, uso y barreras en atención psicológica en España.
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Zamorano, Sara, Ausín, Berta, González-Sanguino, Clara, Castellanos, Miguel Ángel, Saiz, Jesús, Abad, Ana, Vaquero, Carlos, and Muñoz, Manuel
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MENTAL illness ,MEDICAL care use ,COVID-19 pandemic ,MENTAL health ,POPULATION health - Abstract
Copyright of Clínica Contemporánea: Revista de Diagnóstico Psicológico, Psicoterapia y Salud is the property of Colegio Oficial de Psicologos de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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6. Evolution of intersectional perceived discrimination and internalized stigma during COVID-19 lockdown among the general population in Spain.
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Ugidos, Carolina, López-Gómez, Aída, Castellanos, Miguel Ángel, Saiz, Jesús, González-Sanguino, Clara, Ausín, Berta, and Muñoz, Manuel
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POPULATION ,COVID-19 ,INTERNET ,SOCIAL stigma ,FAMILIES ,SURVEYS ,MENTAL depression ,STAY-at-home orders ,ANXIETY ,COVID-19 pandemic ,LONGITUDINAL method - Abstract
Background: Stigma and discrimination have been associated with different diseases and pandemics, with negative consequences for the people who suffered them and for their communities. Currently, COVID-19 has become a new source of stigmatization. Aims: The aim of the present study is to analyze longitudinally the evolution of intersectional perceived discrimination and internalized stigma among the general population of Spain, at three points in time throughout the confinement. Method: Participants completed an online survey. Results: Results show an increase in both variables from the first to the second evaluation, and a slight decrease from the second to the third evaluation. Moreover, these changes are explained by depression, anxiety and family support. Conclusions: These findings indicate the factors that need to be considered to reduce the perception of discrimination and the internalization of stigma, and their detrimental consequences, during an especially stressful event such as the current pandemic outbreak. [ABSTRACT FROM AUTHOR]
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- 2022
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7. LONGITUDINAL STUDY OF AGE-RELATED DIFFERENCES IN THE PSYCHOLOGICAL IMPACT OF CONFINEMENT AS A CONSEQUENCE OF COVID-19 IN A SPANISH SAMPLE.
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Ausín, Berta, González-Sanguino, Clara, Ángel Castellanos, Miguel, Saiz, Jesús, and Muñoz, Manuel
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COVID-19 pandemic ,PSYCHOLOGICAL factors ,POST-traumatic stress disorder ,AGE groups ,PSYCHOLOGICAL adaptation ,INTENSIVE care units ,WELL-being ,INTERNET surveys ,MENTAL health ,LONELINESS - Abstract
Copyright of Behavioral Psychology / Psicologia Conductual is the property of Fundacion VECA para el Avance de la Psicologia Clinica Conductual and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2022
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8. Loneliness, mental health and COVID-19 in the Spanish population.
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Ausín, Berta, González-Sanguino, Clara, Ángel Castellanos, Miguel, Saiz, Jesús, Ugidos, Carolina, López-Gómez, Aída, and Muñoz, Manuel
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Copyright of Psychological Writings / Escritos de Psicología is the property of Psychological Writings / Escritos de Psicologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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9. ESTUDIO LONGITUDINAL DE LA PERCEPCIÓN DE SOLEDAD DURANTE EL CONFINAMIENTO DERIVADO DE LA COVID-19 EN UNA MUESTRA DE POBLACIÓN ESPAÑOLA.
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AUSÍN, BERTA, GONZÁLEZ-SANGUINO, CLARA, ÁNGEL CASTELLANOS, MIGUEL, and MUÑOZ, MANUEL
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Copyright of Acción Psicológica is the property of Editorial UNED and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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10. Effects of COVID-19 Lockdown on Perceived Discrimination and Internalized Stigma in People With Previous Mental Disorder Diagnoses in Spain.
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Saiz, Jesús, Muñoz, Manuel, Ausín, Berta, González-Sanguino, Clara, Ángel Castellanos, Miguel, Vaquero, Carlos, Ugidos, Carolina, and López-Gómez, Aída
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PERCEIVED discrimination , *MENTAL illness , *COVID-19 pandemic , *SOCIAL stigma , *STAY-at-home orders , *CORONAVIRUS diseases - Abstract
COVID-19 disease control efforts and consequences are likely to be complicated by the impact of fear and stigmatization of the novel coronavirus. These complications may also worsen due to the potential compounding of COVID-19 related stigma with stigmatization associated with previously diagnosed conditions. This exploratory study analyzes the experiences of the stigma associated with COVID-19 lockdown in people with different previous diagnoses 2 and 5 weeks after the beginning of the state of emergency in Spain. Gender and age were controlled as covariables and 1,052 people participated in the study. The diagnosis groups were: Psychiatry and mental health (n = 71), Cardiovascular disease (n = 42), Neurological disease (n = 23), Lung disease (n = 53), and No diagnosis (n = 863). The instruments used to measure the stigma were the Intersectional Day-to-Day Discrimination Index and two items of the Internalized Stigma of Mental Illness scale. Analysis of covariance of repeated measures and analysis of variance, including Scheffe's post hoc test, were performed. We found significant differences in stigma among the first and second evaluation. Regarding the previous diagnosis, no differences were found at Time 1, but significant differences were found at Time 2, with those having a previous psychiatric or mental health diagnosis reporting higher levels of perceived discrimination and internalized stigmatization. Our results suggest that people with previous stigmatizing conditions might be more vulnerable to experiencing stigma in a confinement situation. In order to reduce the burden of the COVID-19 stigma, health interventions should also consider the resulting intersection of effects on internalized stigma and perceived discrimination. Public Policy Relevance Statement: During COVID-19 lockdown, the experiences of stigma have been different in people with diverse previous diagnoses. People with a previous psychiatric or mental health diagnosis reported an increase in stigma experiences. It is thus important that policy-makers incorporate an intersectional perspective in their prevention and intervention efforts in reducing the stigma provoked by COVID-19 alarm. [ABSTRACT FROM AUTHOR]
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- 2021
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11. Gender-related differences in the psychological impact of confinement as a consequence of COVID-19 in Spain.
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Ausín, Berta, González-Sanguino, Clara, Castellanos, Miguel Ángel, and Muñoz, Manuel
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COVID-19 pandemic ,MENTAL health ,STAY-at-home orders ,GENDER inequality ,HOUSEKEEPING - Abstract
The Covid-19 pandemic has caused a significant effect on our mental health. In this research, we aim to analyse gender-related differences in the psychological impact of the Covid-19 lockdown in Spain. A cross-sectional study was conducted through an online survey (n = 1041) with two measurements: at two and five weeks after the declaration of the state of emergency and stay-at-home order in Spain. The presence of depressive symptoms, anxiety and post-traumatic stress disorder (PTSD), perceived loneliness and spiritual well-being were evaluated. Linear mixed models with random slopes were calculated for each variable in the study in order to analyse the effect of longitudinal measures and interaction with gender. Women showed more symptoms of depression, anxiety and PTSD, more feelings of loneliness and less spiritual well-being compared to men. The psychological impact caused by the pandemic is maintained over time and increases for depression. Covid-19 appears to be having a greater psychological impact on women than men. More attention needs to be paid to this issue to establish the causes and reduce these differences. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Mental Health Consequences of the Coronavirus 2020 Pandemic (COVID-19) in Spain. A Longitudinal Study.
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González-Sanguino, Clara, Ausín, Berta, Castellanos, Miguel Ángel, Saiz, Jesús, López-Gómez, Aída, Ugidos, Carolina, and Muñoz, Manuel
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COVID-19 ,MENTAL health ,LONELINESS ,MENTAL depression ,POST-traumatic stress ,ANXIETY - Abstract
Background: Covid-19 remains a pandemic that most countries in the world are still dealing with. This is study aims to report the psychological impact of Covid-19 over time on the Spanish population. Methods: A longitudinal study (N = 1041) was carried out with two measurements: after 2 and 5 weeks starting from the declaration of the state of emergency in Spain. The presence of depressive symptoms, anxiety, and posttraumatic stress disease (PTSD) was evaluated by means of screening tests. Sociodemographic data, variables about Covid-19, loneliness, spiritual well-being, social support, discrimination, and a sense of belonging were collected. Results: The data showed how depressive symptomatology increased significantly over time, while anxiety and PTSD did not show statistically significant changes. Spiritual well-being and loneliness were the main predictors of psychological impact. A younger age was a significant predictor of depression and anxiety, while female gender was associated with anxiety and PTSD. Conclusions: The impact of the pandemic is sustained over time, even increasing in depression, and vulnerable groups that need greater psychological health support could be identified. [ABSTRACT FROM AUTHOR]
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- 2020
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13. Self-Compassion and Social Connectedness as Predictors of "Peace and Meaning" during Spain's Initial COVID-19 Lockdown.
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Saiz, Jesús, Ausín, Berta, González-Sanguino, Clara, Castellanos, Miguel Ángel, Salazar, María, Marin, Carolina, López-Gómez, Aída, Ugidos, Carolina, and Muñoz, Manuel
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COVID-19 pandemic ,STAY-at-home orders ,SOCIAL belonging - Abstract
The COVID-19 lockdown has had a massive psychological impact on mental health in the general population, with increases in anxiety, depression, and post-traumatic stress disorder. Spiritual well-being, specifically peace and meaning, has already been identified as one of the main protective factors for these disorders in the COVID-19 context. The aim of the present study is to identify facilitating elements for peace and meaning during the COVID-19 lockdown in Spain. Online surveys were used to obtain data from a sample of 3480 Spanish people. Self-compassion and social support were positively related with peace and meaning, while loneliness and perceived discrimination were negatively related. The model for peace and meaning was statistically significant, explaining 47% of the variance. The significant variables were self-kindness, family support, mindfulness, and sense of belonging having a positive association and loneliness a negative one. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Well-being implications of immobility during COVID-19: evidence from a student sample in Bangladesh using the satisfaction with life scale.
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Jamal, Shaila and Paez, Antonio
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COVID-19 pandemic ,POOR families ,LIFE satisfaction ,DISEASE incidence ,SOCIAL contact - Abstract
Immobility is known to impact health and well-being by reducing social contact, activity participation, and changing time use patterns. These unfortunate effects mostly affect specific demographic segments, including older adults, low income families, people who face disabilities, and those living in conflict zones. Emergency measures taken during the COVID-19 pandemic mandated or strongly recommended limitations to mobility, thereby causing this condition for segments of the public not usually characterized by high levels of immobility. In the context of the pandemic, reduced mobility was the non-pharmaceutical intervention of choice, and the evidence suggests that it helped to keep incidences of the disease from exploding. On the other hand, there is also a need to understand how mobility restrictions may have had incidental impacts, including to well-being, in population groups that have not been studied from this perspective before. In this spirit, the present paper uses the items of the Satisfaction with Life Scale to investigate how aspects of well-being changed during the pandemic, using a sample of 400 college and university students in Dhaka, Bangladesh. Analysis is based on multivariate ordered models and the results suggest that being less mobile, less active, and changes in activity time use due COVID-19 had an impact on the satisfaction with life of students. The detrimental effect was more marked for males and students from low-income households. Additionally, perceptions of residential characteristics and sense of belonging also correlate with satisfaction with life in the period under study. [ABSTRACT FROM AUTHOR]
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- 2024
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15. COVID-19: Uses and Perceptions of Music during Lockdown from a Gender Perspective.
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Arriaga-Sanz, Cristina, Cabedo-Mas, Alberto, Ripollés-Mansilla, Antoni, and Moliner-Miravet, Lidón
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Starting in the middle of March 2020, various lockdown measures and degrees of confinement were put in place in most European countries as a result of the COVID-19 pandemic. Although this situation meant that more people were likely to experience poorer mental health, largely due to the imposition of social distancing measures, many individuals incorporated music into their coping routines to help improve their psychological well-being. Using a gender perspective, this study analyzes how individuals used music during lockdown and explores the differences between men's and women's views on the impact that listening to and making music has on their perceived level of well-being. A questionnaire, MUSIVID19, was administered to a sample of 1868 participants from all the autonomous regions in Spain. The results reveal that in the uses and perceptions of music, the stereotypes underlying the patriarchal system were also reproduced during confinement. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Financial Stress and COVID-19: A Comprehensive Analysis of the Factors Associated with the Pandemic.
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Moon, Keewon, Heo, Wookjae, Lee, Jae Min, and Grable, John E.
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FINANCIAL stress ,FACTOR analysis ,PROPENSITY score matching ,COVID-19 pandemic ,COVID-19 - Abstract
The COVID-19 pandemic introduced unprecedented challenges for households globally, serving as a precursor to and trigger for financial stress. This study examined the associations across various factors thought to be associated with financial stress (a psychological syndrome) resulting from the COVID-19 pandemic. Using survey data collected in 2019 (n = 997) and 2021 (n = 988), propensity score matching and hierarchical linear modeling were employed to identify the association between financial stress and the pandemic. Results indicated that financial stress increased during the COVID-19 pandemic. Three covariate groups, including financial characteristics, health status, and socio-demographic characteristics, were found to be associated with financial stress levels. The primary contribution of this paper lies in offering a comprehensive understanding of how the dynamics of financial stress evolve with shifting macroeconomic events. This paper serves as a framework to employ a comprehensive financial stress measure and matched samples at various data points. Findings from this study contribute to the existing literature on financial well-being, financial stress, and societal outcomes associated with global health events while providing implications for policy and practice. [ABSTRACT FROM AUTHOR]
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- 2023
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17. The economic impact of COVID-19 on cultural tourism: the case of Mosque-Cathedral of Cordoba, Spain.
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Campoy-Muñoz, Pilar, Cardenete, Manuel Alejandro, Delgado, María del Carmen, and Arjona-Fuentes, Juan Manuel
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HERITAGE tourism ,ECONOMIC impact ,TOURIST attractions ,COVID-19 ,TOURISM economics ,COVID-19 pandemic ,SOCIAL accounting ,MONUMENTS - Abstract
This study aims to shed light on the COVID-19 pandemic effects on cultural tourism, given the economic aspects linked to heritage assets arising in cultural tourism destinations. We focus on the case of the Mosque-Cathedral of Cordoba, one of the most visited sites in Spain, analysing how the economic flows generated by this monument have been affected by the outbreak through an applied linear general equilibrium model calibrated by a social accounting matrix. Results indicate that tourism and especially cultural tourism are among the hardest hit sectors during the pandemic. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Serial co-expression analysis of host factors from SARS-CoV viruses highly converges with former high-throughput screenings and proposes key regulators and co-option of cellular pathways
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Manuel Muñoz, Gualberto Asencio-Cortés, Andrés Garzón, Ana María Brokate-Llanos, Antonio J. Pérez-Pulido, Gloria Brea-Calvo, M. Rosario Rodríguez-Griñolo, Pérez-Pulido, Antonio J., Asencio-Cortés, Gualberto, Brokate-Llanos, Ana María, Brea-Calvo, Gloria, Rodríguez-Griñolo, M. Rosario, Garzón, Andrés, Muñoz, Manuel J., Pérez-Pulido, Antonio J. [0000-0003-3343-2822], Asencio-Cortés, Gualberto [0000-0003-0874-1826], Brokate-Llanos, Ana María [0000-0003-1715-8579], Brea-Calvo, Gloria [0000-0001-5536-6868], Rodríguez-Griñolo, M. Rosario [0000-0002-3312-0848], Garzón, Andrés [0000-0003-4299-7198], and Muñoz, Manuel J. [0000-0002-0111-1541]
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Gene Expression Regulation, Viral ,SARS-CoV-2 ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Cellular pathways ,COVID-19 ,Computational Biology ,Host factors ,SARS-CoV ,Co-expressed genes ,Coregulated genes ,Computational biology ,Biology ,medicine.disease_cause ,Article ,High-Throughput Screening Assays ,Coronavirus ,Expression analysis ,medicine ,Humans ,Interferons ,Reverse engineering ,Algorithms - Abstract
Versión postprint publicada en Briefings in Bioinformatics, próximamente disponible en: http://hdl.handle.net/10261/228222, The current genomics era is bringing an unprecedented growth in the amount of gene expression data, only comparable to the exponential growth of sequences in databases during the last decades. This data now allows the design of secondary analyses that take advantage of this information to create new knowledge through specific computational approaches. One of these feasible analyses is the evaluation of the expression level for a gene through a series of different conditions or cell types. Based on this idea, we have developed ASACO, Automatic and Serial Analysis of CO-expression, which performs expression profiles for a given gene along hundreds of normalized and heterogeneous transcriptomics experiments and discover other genes that show either a similar or an inverse behavior. It might help to discover co-regulated genes, and even common transcriptional regulators in any biological model, including human diseases or microbial infections. The present SARS-CoV-2 pandemic is an opportunity to test this novel approach due to the wealth of data that is being generated, which could be used for validating results. In addition, new cell mechanisms identified could become new therapeutic targets. Thus, we have identified 35 host factors in the literature putatively involved in the infectious cycle of SARS-CoV and/or SARS-CoV-2 and searched for genes tightly co-expressed with them. We have found around 1900 co-expressed genes whose assigned functions are strongly related to viral cycles. Moreover, this set of genes heavily overlap with those identified by former laboratory high-throughput screenings (with p-value near 0). Some of these genes aim to cellular structures such as the stress granules, which could be essential for the virus replication and thereby could constitute potential targets in the current fight against the virus. Additionally, our results reveal a series of common transcription regulators, involved in immune and inflammatory responses, that might be key virus targets to induce the coordinated expression of SARS-CoV-2 host factors. All of this proves that ASACO can discover gene co-regulation networks with potential for proposing new genes, pathways and regulators participating in particular biological systems.
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- 2020
19. The Psychological Impact of the COVID-19 Pandemic in Spain: A Longitudinal Study.
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Ausín, Berta, González-Sanguino, Clara, Castellanos, Miguel Ángel, Sáiz, Jesús, Zamorano, Sara, Vaquero, Carlos, and Muñoz, Manuel
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CORONAVIRUS diseases , *PSYCHOLOGICAL factors , *COVID-19 pandemic , *PANDEMICS , *POST-traumatic stress , *QUARANTINE , *MENTAL health , *SOCIAL support , *LONELINESS - Abstract
Background: This study aims to longitudinally assess the psychological impact of the COVID-19 pandemic in the general Spanish population. It uses four assessment points: two weeks after the start of confinement, one month after, two months after, and one year after the first evaluation. Methods: Evaluations were conducted through an online survey, with a sample of 3,480 people at the first data collection and 1,041, 569, and 550 people at successive evaluation points. Depressive symptoms (PHQ-2), anxiety (GAD-2), post-traumatic stress (PCL-C-2), social support (EMAS), loneliness (UCLA-3), and discrimination (InDI-d) were evaluated. Results: Significant changes were found in the variables depression and anxiety with a greater presence of this kind of symptomatology after one year (p < .01). There were also significant changes in the variable social support, which showed a substantial reduction after one year (p < .001). Similarly, there were significant variations in the variable intersectional discrimination (p < .001), with greater levels of discrimination. The temporal models show no significant differences in terms of post-traumatic symptomatology (p = .12) or loneliness (p = .19). Conclusions: The pandemic had a negative impact on mental health and these effects were further exacerbated one year later. [ABSTRACT FROM AUTHOR]
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- 2022
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20. Mortality and other adverse outcomes in patients with type 2 diabetes mellitus admitted for COVID-19 in association with glucose-lowering drugs: a nationwide cohort study.
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Pérez-Belmonte, Luis M., Torres-Peña, José David, López-Carmona, María D., Ayala-Gutiérrez, M. Mar., Fuentes-Jiménez, Francisco, Huerta, Lucía Jorge, Muñoz, Jaime Alonso, Rubio-Rivas, Manuel, Madrazo, Manel, Garcia, Marcos Guzmán, Montes, Beatriz Vicente, Sola, Joaquim Fernández, Ena, Javier, Ferrer, Ruth Gonzalez, Pérez, Carmen Mella, Ripper, Carlos Jorge, Lecumberri, Jose Javier Napal, Acedo, Iris El Attar, Canteli, Susana Plaza, and Cosío, Sara Fuente
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TYPE 2 diabetes ,COVID-19 ,ARTIFICIAL respiration ,PROPENSITY score matching ,INTENSIVE care units - Abstract
Background: Limited evidence exists on the role of glucose-lowering drugs in patients with COVID-19. Our main objective was to examine the association between in-hospital death and each routine at-home glucose-lowering drug both individually and in combination with metformin in patients with type 2 diabetes mellitus admitted for COVID-19. We also evaluated their association with the composite outcome of the need for ICU admission, invasive and non-invasive mechanical ventilation, or in-hospital death as well as on the development of in-hospital complications and a long-time hospital stay.Methods: We selected all patients with type 2 diabetes mellitus in the Spanish Society of Internal Medicine's registry of COVID-19 patients (SEMI-COVID-19 Registry). It is an ongoing, observational, multicenter, nationwide cohort of patients admitted for COVID-19 in Spain from March 1, 2020. Each glucose-lowering drug user was matched with a user of other glucose-lowering drugs in a 1:1 manner by propensity scores. In order to assess the adequacy of propensity score matching, we used the standardized mean difference found in patient characteristics after matching. There was considered to be a significant imbalance in the group if a standardized mean difference > 10% was found. To evaluate the association between treatment and study outcomes, both conditional logit and mixed effect logistic regressions were used when the sample size was ≥ 100.Results: A total of 2666 patients were found in the SEMI-COVID-19 Registry, 1297 on glucose-lowering drugs in monotherapy and 465 in combination with metformin. After propensity matching, 249 patients on metformin, 105 on dipeptidyl peptidase-4 inhibitors, 129 on insulin, 127 on metformin/dipeptidyl peptidase-4 inhibitors, 34 on metformin/sodium-glucose cotransporter 2 inhibitor, and 67 on metformin/insulin were selected. No at-home glucose-lowering drugs showed a significant association with in-hospital death; the composite outcome of the need of intensive care unit admission, mechanical ventilation, or in-hospital death; in-hospital complications; or long-time hospital stays.Conclusions: In patients with type 2 diabetes mellitus admitted for COVID-19, at-home glucose-lowering drugs showed no significant association with mortality and adverse outcomes. Given the close relationship between diabetes and COVID-19 and the limited evidence on the role of glucose-lowering drugs, prospective studies are needed. [ABSTRACT FROM AUTHOR]- Published
- 2020
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21. Mental health consequences during the initial stage of the 2020 Coronavirus pandemic (COVID-19) in Spain.
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González-Sanguino, Clara, Ausín, Berta, Castellanos, Miguel Ángel, Saiz, Jesús, López-Gómez, Aída, Ugidos, Carolina, and Muñoz, Manuel
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COVID-19 pandemic , *LONELINESS , *COVID-19 , *MENTAL health , *SCIENTIFIC literature , *POST-traumatic stress disorder - Abstract
• The 18.7% of the sample revealed depressive symptomatology, the 21.6% anxiety and the 15.8% PSTD. • Being older, economic stability and information were negatively related to the symptomatology. • Female, previous diagnoses or Covid-19 symptoms were associated with symptomatology. • Spiritual well-being was a common protector for all symptomatology and the loneliness a predictor. The pandemic caused by Covid-19 has been an unprecedented social and health emergency worldwide. This is the first study in the scientific literature reporting the psychological impact of the Covid-19 outbreak in a sample of the Spanish population. A cross-sectional study was conducted through an online survey of 3480 people. The presence of depression, anxiety and post-traumatic stress disorder (PTSD) was evaluated with screening tests from 14 March. Sociodemographic and Covid-19-related data was collected. Additionally, spiritual well-being, loneliness, social support, discrimination and sense of belonging were assessed. Descriptive analyses were carried out and linear regression models compiled. The 18.7% of the sample revealed depressive, 21.6% anxiety and 15.8% PTSD symptoms. Being in the older age group, having economic stability and the belief that adequate information had been provided about the pandemic were negatively related to depression, anxiety and PTSD. However, female gender, previous diagnoses of mental health problems or neurological disorders, having symptoms associated with the virus, or those with a close relative infected were associated with greater symptomatology in all three variables. Predictive models revealed that the greatest protector for symptomatology was spiritual well-being, while loneliness was the strongest predictor of depression, anxiety and PTSD. The impact on our mental health caused by the pandemic and the measures adopted during the first weeks to deal with it are evident. In addition, it is possible to identify the need of greater psychological support in general and in certain particularly vulnerable groups. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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22. A DNA intercalating dye-based RT-qPCR alternative to diagnose SARS-CoV-2
- Author
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Juan C. Muñoz, Gonzalo Cabrerizo, Marcos Palavecino, Manuel J. Muñoz, José N. Stigliano, Nicolás Nieto Moreno, Anabella Srebrow, Ignacio E Schor, Fabian Rudolf, Micaela A. Godoy Herz, Martín Avaro, Cybele C. García, Elsa Baumeister, Valeria Buggiano, Lucas Servi, Estefanía Benedetti, Federico Remes Lenicov, Alberto R. Kornblihtt, Laureano Bragado, Ezequiel Petrillo, Federico Fuchs Wightman, Andrea Pontoriero, José Clemente, and Manuel de la Mata
- Subjects
2019-20 coronavirus outbreak ,RDRP ,Diagnostic methods ,Coronavirus disease 2019 (COVID-19) ,Computer science ,diagnosis ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,TaqMan ,Early detection ,SARS-COV-2 ,Computational biology ,Diamines ,Biology ,DIAGNOSIS ,Real-Time Polymerase Chain Reaction ,Sensitivity and Specificity ,SYBR GREEN ,Limited access ,purl.org/becyt/ford/3.3 [https] ,03 medical and health sciences ,Technical Report ,0302 clinical medicine ,Nasopharynx ,TAQMAN ,RT-QPCR ,Humans ,SYBR Green ,Benzothiazoles ,Molecular Biology ,DNA Primers ,030304 developmental biology ,RdRP ,0303 health sciences ,Technical Paper ,SARS-CoV-2 ,RT-qPCR ,COVID-19 ,DNA ,Cell Biology ,Gold standard (test) ,Intercalating Agents ,COVID-19 Nucleic Acid Testing ,030220 oncology & carcinogenesis ,Quinolines ,RNA ,RNA, Viral ,purl.org/becyt/ford/3 [https] ,Alternative strategy - Abstract
Early detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been proven crucial during the efforts to mitigate the effects of the COVID-19 pandemic. Several diagnostic methods have emerged in the past few months, each with different shortcomings and limitations. The current gold standard, RT-qPCR using fluorescent probes, relies on demanding equipment requirements plus the high costs of the probes and specific reaction mixes. To broaden the possibilities of reagents and thermocyclers that could be allocated towards this task, we have optimized an alternative strategy for RT-qPCR diagnosis. This is based on a widely used DNA-intercalating dye and can be implemented with several different qPCR reagents and instruments. Remarkably, the proposed qPCR method performs similarly to the broadly used TaqMan-based detection, in terms of specificity and sensitivity, thus representing a reliable tool. We think that, through enabling the use of vast range of thermocycler models and laboratory facilities for SARS-CoV-2 diagnosis, the alternative proposed here can increase dramatically the testing capability, especially in countries with limited access to costly technology and reagents. Fil: Fuchs Wightman, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Godoy Herz, Micaela Amalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Muñoz, Juan Cristóbal. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Stigliano, Jose Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Bragado, Laureano Fabian Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Nieto Moreno, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Palavecino Ruiz, Marcos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Servi, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Cabrerizo, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: Clemente, Jose Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Avaro, Martín. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Pontoriero, Andrea. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Benedetti, Estefanía. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Baumeister, Elsa. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina Fil: Rudolf, Fabian. Eidgenössische Technische Hochschule Zürich; Suiza Fil: Remes Lenicov, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Buggiano, Valeria Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Kornblihtt, Alberto Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Srebrow, Anabella. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: de la Mata, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Muñoz, Manuel Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Schor, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Petrillo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
- Published
- 2021
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