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COVID-19 pandemic-borne wastes imposed a severe threat to human lives as well as the total environment. Improper handling of these wastes increases the possibility of future transmission. Therefore, immediate actions are required from both local and international authorities to mitigate the amount of waste generation and ensure proper disposal of these wastes, especially for low-income and developing countries where solid waste management is challenging. In this study, an attempt is made to estimate healthcare waste generated during the COVID-19 pandemic in Bangladesh. This study includes infected, ICU, deceased, isolated and quarantined patients as the primary sources of medical waste. Results showed that COVID-19 medical waste from these patients was 658.08 tons in March 2020 and increased to 16,164.74 tons in April 2021. A top portion of these wastes was generated from infected and quarantined patients. Based on survey data, approximate daily usage of face masks and hand gloves is also determined. Probable waste generation from COVID-19 confirmatory tests and vaccination has been simulated. Finally, several guidelines are provided to ensure the country's proper disposal and management of COVID-related wastes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)

This study examined the food insecurity and coping mechanisms among the indigenous Bangladeshi population of the Chittagong Hill Tracts (CHT) region to extract empirical evidence on the ongoing discussion on the COVID-19 pandemic-exacerbated food-insecurity situation. The study adopted a qualitative approach by interviewing 60 indigenous households. Data were collected in two phases between 15 June 2020, and 30 July 2021 in Bangladesh’s Chittagong Hill Tracts (CHT) region. Thematic data analyses were performed using the Granheim approach and NVivo-12 software. The authors used Huston’s social–ecological theory to explain the indigenous coping mechanisms. The research evidence revealed that most households experienced challenges over daily foods, manifesting in the decreasing consumption of them, the increased price of food items, a food crisis due to an income shock, malnutrition, the shifting to unhealthy food consumption, starvation and hunger, and food insufficiency, thereby leading to mental stress. This study further revealed that the indigenous population took crucial coping strategies to survive the pandemic. In response to COVID-19, they took loans and borrowed foods, reduced expenses, changed their food habits, avoided nutritional foods, relied on vegetables, sold domestic animals and properties, collected forest and hill foods, and depended on governmental and societal relief. This study also provides the in-depth policy actions for the urgent intervention of government, stakeholders, policymakers, NGOs, and development practitioners to take necessary initiatives to enhance the quality of life of the people that were affected by the post-pandemic recovery period.

Food insecurity is one of the rising problems in Bangladesh, and it is severely prevalent among informal migrant workers. In this case, the COVID‐19 pandemic has multiplied the food insecurity of informal migrant workers. This study explores and synthesizes the COVID‐19 induced food insecurity impact among informal migrants and recommends policy actions to tackle the COVID‐19 led food crisis in Bangladesh. A qualitative research approach, including in‐depth interviews, four FGDs, and participant observation, has been applied to data collection from different parts of Dhaka city. A thematic approach to interpretive phenomenological analysis is followed in this study. The results show that COVID‐19 induced lockdown significantly affects informal migrants' household food security. Most participants report severe complications due to food insecurity like consuming less food, price hiking, no fish or meat, potato, and vegetable. Food insecurity leads to migrant's chronic food shortage, starvation, malnutrition of mother and children, and unhealthy food. As a result, the way of life of informal migrants has been directed to more fragility and vulnerability during the pandemic; even they are not affordable to maintain a minimal level of family affairs and necessity. The findings of this study would be essential guidelines for the governmental and non‐governmental organizations and development practitioners to address the food insecurity situations. [ABSTRACT FROM AUTHOR]

This study examined the food insecurity and coping mechanisms among the indigenous Bangladeshi population of the Chittagong Hill Tracts (CHT) region to extract empirical evidence on the ongoing discussion on the COVID-19 pandemic-exacerbated food-insecurity situation. The study adopted a qualitative approach by interviewing 60 indigenous households. Data were collected in two phases between 15 June 2020, and 30 July 2021 in Bangladesh's Chittagong Hill Tracts (CHT) region. Thematic data analyses were performed using the Granheim approach and NVivo-12 software. The authors used Huston's social–ecological theory to explain the indigenous coping mechanisms. The research evidence revealed that most households experienced challenges over daily foods, manifesting in the decreasing consumption of them, the increased price of food items, a food crisis due to an income shock, malnutrition, the shifting to unhealthy food consumption, starvation and hunger, and food insufficiency, thereby leading to mental stress. This study further revealed that the indigenous population took crucial coping strategies to survive the pandemic. In response to COVID-19, they took loans and borrowed foods, reduced expenses, changed their food habits, avoided nutritional foods, relied on vegetables, sold domestic animals and properties, collected forest and hill foods, and depended on governmental and societal relief. This study also provides the in-depth policy actions for the urgent intervention of government, stakeholders, policymakers, NGOs, and development practitioners to take necessary initiatives to enhance the quality of life of the people that were affected by the post-pandemic recovery period. [ABSTRACT FROM AUTHOR]

The devastating outbreak of COVID-19 has spread all over the world and has become a global health concern. There is no specific therapeutics to encounter the COVID-19. Small interfering RNA (siRNA)-based therapy is an efficient strategy to control human viral infections employing post-transcriptional gene silencing (PTGS) through neutralizing target complementary mRNA. RNA-dependent RNA polymerase (RdRp) encoded by the viral RdRp gene as a part of the replication-transcription complex can be adopted as an acceptable target for controlling SARS-CoV-2 mediated infection. Therefore, in the current study, accessible siRNA designing tools, including significant algorithms and parameters, were rationally used to design the candidate siRNAs against SARS-COV-2 encoded RdRp. The designed siRNA molecules possessed adequate nucleotide-based and other features for potent gene silencing. The targets of the designed siRNAs revealed no significant matches within the whole human genome, ruling out any possibilities for off-target silencing by the siRNAs. Characterization with different potential parameters of efficacy allowed selecting the finest siRNA among all the designed siRNA molecules. Further, validation assessment and target site accessibility prediction also rationalized the suitability of this siRNA molecule. Molecular docking study between the selected siRNA molecule and component of RNA interference (RNAi) pathway gave an excellent outcome. Molecular dynamics of two complexes: siRNA and argonaute complex, guide RNA, and target protein complex, have shown structural stability of these proteins. Therefore, the designed siRNA molecule might act as an effective therapeutic agent against the SARS-CoV-2 at the genome level and can prevent further outbreaks of COVID-19 in humans. • Designed siRNAs can contribute as effective therapeutic agent against SARS-CoV-2. • Target specific designing of siRNAs for post-transcriptional gene silencing of SARS-CoV-2 RdRp gene • Molecular interaction and dynamics analysis of siRNA‑argonaute protein docked complex using bioinformatics tools • Computational validation of designed siRNA off-target silencing possibilities within the whole human genome [ABSTRACT FROM AUTHOR]