1. PREPARATION OF COVALENTLY BONDED SILICA-ALGINATE HYBRID HYDROGELS BY SCHIFF BASE AND SOL-GEL REACTIONS
- Author
-
Aurora C. Hernández-González, Lucía Téllez-Jurado, Luis M. Rodríguez-Lorenzo, Agencia Estatal de Investigación (España), Instituto Politécnico Nacional (México), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Consejo Nacional de Ciencia y Tecnología (México), Luis M. Rodríguez-Lorenzo, and Luis M. Rodríguez-Lorenzo [0000-0002-4816-1087]
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,Schiff base ,Polymers and Plastics ,Silica-alginate hybrids ,Organic Chemistry ,Ionic bonding ,nutritional and metabolic diseases ,hemic and immune systems ,sol-gel process ,chemistry.chemical_compound ,enzymes and coenzymes (carbohydrates) ,synthesis parameters ,chemistry ,Covalent bond ,immune system diseases ,Triethoxysilane ,Polymer chemistry ,Self-healing hydrogels ,Materials Chemistry ,Alginate dialdehyde ,Alginate hydrogel ,Hybrid material ,Sol-gel - Abstract
Organic-inorganic hybrid materials overcome drawbacks associated with alginate hydrogels. In this work, covalently coupled silica-alginate hybrids were prepared by Schiff base formation and sol-gel reaction using alginate dialdehyde (ADA), (3- Aminopropyl) triethoxysilane (APTES), and APTES/tetraethylorthosilicate (TEOS) precursors. The influence of the polysaccharide/inorganic ratio, the nature of the inorganic precursor and the ionic crosslinking ability are studied. Prepared hybrids were characterized by FT-IR, 13C and 29Si -NMR spectroscopies, SEM, and rheology. For ADA/APTES hybrids, at higher ADA content, Schiff base formation is predominant, but at lower ADA content, the sol-gel reaction is prevalent. However, the progress of the sol-gel reactions for ADA/(APTES+TEOS), is favored with higher ADA compositions. Introducing a posterior ionic crosslinking treatment was possible, increasing the moduli in ADA/(APTES+TEOS) hybrids from 86207Pa for 1.5 ADA/Si to 362171Pa for 1.5 ADA/Si-Ca. In-situ ADA-Silica hybrid hydrogels containing both ionic and covalent crosslinking can be successfully synthesized with the proposed method., Instituto Politécnico Nacional, México (IPN-SIP 20196660 and IPN-SIP 20201294), AEI/FEDER,UE (DPI2017-90147-R), CONACYT scholarship.
- Published
- 2021