1. Natural Variation of Hazelnut Allergenicity: Is There Any Potential for Selecting Hypoallergenic Varieties?
- Author
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Ribeiro M, Costa J, Mafra I, Cabo S, Silva AP, Gonçalves B, Hillion M, Hébraud M, and Igrejas G
- Subjects
- Adolescent, Adult, Aged, Allergens genetics, Antigens, Plant, Child, Preschool, Corylus adverse effects, Female, Humans, Immunoglobulin E immunology, Male, Middle Aged, Proteomics, Young Adult, Corylus genetics, Corylus immunology, Food Hypersensitivity etiology, Genetic Variation, Nut Hypersensitivity etiology, Plant Proteins adverse effects
- Abstract
Hazelnuts ( Corylus avellana L.) have an important role in human nutrition and health. However, they are a common cause of food allergy. Due to hazelnut varietal diversity, variety-dependent differences in the IgE-binding properties may be suspected, which could allow therapeutic strategies based on the use of hypoallergenic varieties to induce desensitization. In a proteogenomic approach, we aimed to evaluate the allergenic potential of a genetically diverse set of hazelnuts (n = 13 varieties). Minor differences were found at the level of genes encoding important allergens, namely Cor a 8, Cor a 9, and Cor a 14. Nevertheless, IgE-reactivity was similar for all varieties using sera from seven allergic individuals. The predominant IgE-reactive proteins were Cor a 9 (100%) and Cor a 1.04 (60%), with the former being the most frequently identified by a two-dimensional gel electrophoresis (2-DE)-based proteomic approach. Therefore, it seems that the conventional exclusion diet will hold its ground for the time being.
- Published
- 2020
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