1. Duplication of the pituitary gland in a newborn with median cleft face syndrome and nasal teratoma
- Author
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Michèle Hamon-Kérautret, Jean-Pierre Pruvo, Xavier Demondion, Gustavo Soto Ares, Véronique Rouland, and Jean-Paul Francke
- Subjects
Prechordal plate ,Pituitary gland ,Nose Neoplasms ,Corpus callosum ,Gene duplication ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Nose ,Respiratory distress ,business.industry ,Infant, Newborn ,Teratoma ,Syndrome ,Anatomy ,medicine.disease ,Magnetic Resonance Imaging ,Hypoplasia ,Cleft Palate ,medicine.anatomical_structure ,Pituitary Gland ,Pediatrics, Perinatology and Child Health ,Nasal Cavity ,Tomography, X-Ray Computed ,business - Abstract
A newborn suffered immediate neonatal respiratory distress because of an obstructive, soft-tissue nasal mass. Clinical examination revealed a cleft palate with a protruding polypoid mass. CT and MRI showed a heterogeneous nasopharyngeal mass and associated intracranial abnormalities - duplication of the hypophysis and hypoplasia of the corpus callosum. Duplication of the hypophysis is a very rare malformation, only 13 cases having been previously described. The suggested pathogenesis is duplication of the prechordal plate and anterior end of the notochord during early embryological development.
- Published
- 1998
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