3 results on '"Jahaj E"'
Search Results
2. Clinical Study of Hyperglycemia and SARS-CoV-2 Infection in Intensive Care Unit Patients.
- Author
-
Ilias I, Jahaj E, Kokkoris S, Zervakis D, Temperikidis P, Magira E, Pratikaki M, Vassiliou AG, Routsi C, Kotanidou A, and Dimopoulou I
- Subjects
- Betacoronavirus pathogenicity, Blood Glucose metabolism, COVID-19, Coronavirus Infections complications, Coronavirus Infections virology, Diabetes Mellitus genetics, Diabetes Mellitus virology, Female, Hospitalization, Humans, Hyperglycemia complications, Hyperglycemia virology, Intensive Care Units, Male, Middle Aged, Pandemics, Pneumonia, Viral complications, Pneumonia, Viral virology, Respiration, Artificial, Respiratory Insufficiency physiopathology, Respiratory Insufficiency therapy, SARS-CoV-2, Severe Acute Respiratory Syndrome complications, Severe Acute Respiratory Syndrome therapy, Severe Acute Respiratory Syndrome virology, Coronavirus Infections therapy, Diabetes Mellitus therapy, Hyperglycemia therapy, Insulin metabolism, Pneumonia, Viral therapy
- Abstract
Background/aim: Reports indicate that coronaviridae may inhibit insulin secretion. In this report we aimed to describe the course of glycemia in critically ill patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection., Patients and Methods: We studied 36 SARS-CoV-2 patients (with no history of diabetes) in one intensive care unit (ICU). All the patients were admitted for hypoxemic respiratory failure; all but four required mechanical ventilation. The mean (±SD) age of the patients was 64.7 (9.7) years; 27 were men; the mean (±SD) duration of ICU stay was 12.9 (8.3 days)., Results: Twenty of 36 patients presented with hyperglycemia; brief intravenous infusions of short-acting insulin were administered in six patients. As of May 29 2020, 11 patients had died (seven with hyperglycemia). In 17 patients the Hyperglycemia Index [HGI; defined as the area under the curve of (hyper)glycemia level*time (h) divided by the total time in the ICU] was <16.21 mg/dl (0.90 mmol/l), whereas in three patients the HGI was ≥16.21 mg/dl (0.90 mol/l) and <32.25 mg/dl (1.79 mmol/l)., Conclusion: In our series of ICU patients with SARS-CoV-2 infection, and no history of diabetes, a substantial number of patients had hyperglycemia, to a higher degree than would be expected by the stress of critical illness, lending credence to reports that speculated a tentative association between SARS-CoV-2 and hyperglycemia. This finding is important, since hyperglycemia can lead to further infectious complications., (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
3. Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity.
- Author
-
Halvatsiotis P, Kotanidou A, Tzannis K, Jahaj E, Magira E, Theodorakopoulou M, Konstandopoulou G, Gkeka E, Pourzitaki C, Kapravelos N, Papoti S, Sileli M, Gogos C, Velissaris D, Markou N, Stefanatou E, Vlachogianni G, Aimoniotou E, Komnos A, Zafeiridis T, Koulouvaris P, Armaganidis A, Bamias A, and Dimopoulos G
- Subjects
- Aged, COVID-19, Comorbidity, Coronavirus Infections complications, Coronavirus Infections epidemiology, Coronavirus Infections virology, Diabetes Mellitus physiopathology, Diabetes Mellitus virology, Female, Greece epidemiology, Hospitalization, Humans, Male, Middle Aged, Obesity physiopathology, Obesity virology, Pandemics, Pneumonia, Viral complications, Pneumonia, Viral epidemiology, Pneumonia, Viral virology, Prognosis, Retrospective Studies, Risk Factors, SARS-CoV-2, Survival Rate, Betacoronavirus isolation & purification, Coronavirus Infections mortality, Critical Illness mortality, Diabetes Mellitus mortality, Obesity mortality, Pneumonia, Viral mortality
- Abstract
Aims: The aim of the study was to investigate the association between type-2 diabetes mellitus, other underlying diseases and obesity with the outcomes of critically ill Covid-19 patients in Greece., Methods: In this retrospective observational multi-centre study, data and outcomes of 90 RNA 2109-nCoV confirmed critically ill patients from 8 hospitals throughout Greece, were analysed. All reported information stand through April 13th 2020., Results: The median age of the patients was 65.5 (IQR 56-73), majority were male (80%) and obesity was present in 34.4% of patients most prevalent to younger than 55 years. Hypertension was the prevailing comorbidity (50%), followed by cardiovascular diseases (21.1%) and type-2 diabetes (18.9%). At admission, common symptoms duration had a median of 8 (IQR 5-11) days. A 13.3% of the patients were discharged, 53.4% were still in the ICUs and 28.9% deceased who were hospitalised for fewer days than the survivors [6 (IQR 3-9) vs. 9 (IQR 7-14.5) respectively]. Aging was not a risk factor but diabetes deteriorates the outcomes. Obesity poses a suggestive burden as it was more notable in deceased versus survivors., Conclusions: Type 2 diabetes and obesity may have contributed to disease severity and mortality in COVID-19 critically ill patients in Greece., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.