Background: recent points of view catch us attention to the importance of continuing to practice physical activity during the Covid-19 pandemic, however few studies have analyzed the association between physical activity and worsening of the clinical outcome, hospitalizations or mortality from the new coronavirus Objective: to analyze the association between physical activity and deaths by Covid-19 in the Brazilian capitals. Methods: observational cross-sectional ecological study, when data on prevalence of leisure time physical activity and deaths by Covid-19 were analyzed in 26 Brazilian capitals and the Federal District as well. Data on the prevalence of leisure time physical activity, obesity and hypertension has been collected through the Risk Factors Surveillance System for chronic non-communicable diseases of the Brazilian Ministry of Health were used. Information on accumulated deaths, lethality of the disease and mortality rate were extracted from SUS(Brazil's Unified National Health System) Analytical: data on COVID-19 in Brazil, available on the website of the Brazilian Ministry of Health. For data analysis, simple Pearson correlation and multiple regression were used with a 5% significance level. Results: demonstrate the existence of an inverse correlation between leisure time physical activity and accumulated deaths (r = -0.44, p = 0.03), mortality rate/100,000 inhabitants (r = -0.43, p = 0.02) as well as with the lethality of the disease (r = -0.51, p = 0.01). They also demonstrate an inverse association between leisure time physical activity and accumulated deaths (β = -485.1, p = 0.04), as well as with the lethality of the disease (β = -0.21, p = 0.02), even after adjusting for confounding variables. Conclusions: the practice of leisure time physical activity can be an important ally in coping with Covid-19. The inverse association observed among physical activity, accumulated deaths and disease lethality can bring important reflections on the actions that have been implemented by government agencies, both state and municipal regarding the practice of physical activity by the population.