1. Testosterone, Hemostasis, and Cardiovascular Diseases in Men.
- Author
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Brodin, Ellen, Vikan, Torkel, Hansen, John-Bjarne, and Svartberg, Johan
- Subjects
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CARDIOVASCULAR diseases , *ADVERSE health care events , *AGE , *TESTOSTERONE , *FIBRINOLYTIC agents - Abstract
Men have a higher incidence of cardiovascular disease (CVD) than women, and adverse thrombotic events increase with age. Recent experimental cross-sectional, and case-control studies have shown that testosterone may affect the hemostatic/fibrinolytic system in men in several ways. It has been hypothesized that physiological doses of testosterone would have a beneficial effect on tissue factor-induced thrombin generation and the development of CVD. The search for eternal youth has created a market for testosterone treatment in aging men during the last few years. However, whether testosterone supplementation could be useful in the treatment of testosterone-deficient elderly men is still controversial. The present review focuses on the coagulation system and CVD from the perspective of testosterone. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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