1. Accuracy of ultra-high-resolution computed tomography with a 0.3-mm detector for quantitative assessment of coronary artery stenosis grading in comparison with conventional computed tomography: A phantom study.
- Author
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Yamada M, Yamada Y, Nakahara T, Okuda S, Abe T, Kuribayashi S, and Jinzaki M
- Subjects
- Constriction, Pathologic, Coronary Angiography methods, Humans, Phantoms, Imaging, Predictive Value of Tests, Tomography, X-Ray Computed methods, Coronary Stenosis diagnostic imaging, Coronary Stenosis pathology
- Abstract
Background: The development of ultra-high-resolution CT (U-HRCT) is expected to improve the accuracy of coronary stenosis evaluation. This study aimed to evaluate the accuracy of the stenosis severities of coronary artery phantoms estimated using U-HRCT by comparing them to those estimated with conventional CT., Methods: Coronary artery phantoms with non-calcified and calcified lesions were scanned with conventional CT (64-row × 0.625 mm) and U-HRCT (32-row × 0.3125 mm). The coronary artery phantoms had lumen diameters of 2.0, 3.0, and 4.0 mm with non-calcified lesions representing 0%, 25%, 50%, and 75% stenosis and 3.0 and 4.0 mm with calcified lesions representing 0%, 25%, 50%, and 75% stenosis. The lumen diameters at the stenotic and non-stenotic regions were measured, and the stenosis severities were compared with the true values., Results: For non-calcified lesions, conventional CT significantly underestimated the stenosis severity in the phantom showing 75% stenosis with lumen diameters of 2.0 and 3.0 mm (p < 0.05), while the estimated stenosis severities were not significantly different from the true values at all settings with U-HRCT. For the calcified lesions, conventional CT overestimated the stenosis severities at all settings (p < 0.05), while U-HRCT yielded estimations closer to the true values, although still with some overestimation (p < 0.05)., Conclusion: By using U-HRCT, the estimated stenosis severities of the coronary artery with non-calcified lesion become almost equal to the true value, while those with calcified lesion are still overestimated although they become closer to the true value., Competing Interests: Declaration of competing interest Sachio Kuribayashi received a grant from General Electric Healthcare Japan. However, the funder was not involved in the design of the study; collection, analysis, and interpretation of the data; or writing of the manuscript. All other authors have no conflict of interest to declare., (Copyright © 2021. Published by Elsevier Inc.)
- Published
- 2022
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