27 results on '"MURRAY RG"'
Search Results
2. Apolipoprotein epsilon 4 and coronary artery disease.
- Author
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Payne MN, Green E, Walker MR, Beattie JM, Murray RG, and Jones AF
- Subjects
- Apolipoprotein E4, Coronary Disease genetics, Female, Genotype, Humans, Male, Middle Aged, United Kingdom epidemiology, Apolipoproteins E blood, Coronary Disease epidemiology, Gene Frequency
- Published
- 1992
3. Sustained improvement in left ventricular function after successful coronary angioplasty.
- Author
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Perry RA, Singh A, Seth A, Flint EJ, Hunt A, Murray RG, and Shiu MF
- Subjects
- Coronary Disease physiopathology, Exercise Test, Female, Gated Blood-Pool Imaging, Humans, Male, Middle Aged, Myocardial Infarction physiopathology, Stroke Volume physiology, Time Factors, Angioplasty, Balloon, Coronary, Coronary Disease therapy, Ventricular Function, Left physiology
- Abstract
The short and long term effects of successful percutaneous transluminal coronary angioplasty on left ventricular function, at rest and on exercise were investigated in 49 patients. Thirty-four had had no previous infarction (group 1) and 15 had (group 2). Technetium-99m gated blood pool images were obtained at rest and during exercise before, six weeks after, and a mean of fifteen months after successful angioplasty. Before angioplasty the mean (SD) ejection fraction fell significantly on exercise in both groups from 58 (10)% to 53 (13)% in group 1 and from 48 (10)% to 40 (16)% in group 2. This change was paralleled by a worsening wall motion score (from 0.6 (0.4) to 1.6 (1.2) in group 1 and from 2.3 (1.9) to 3.3 (2.4) in group 2). Six weeks after the procedure there was little change in resting ejection fraction but it increased significantly on exercise (to 62 (11)% in group 1 and to 53 (13)% in group 2). There was a concomitant significant improvement in the exercise wall motion score (to 0.4 (0.6) in group 1 and to 1.8 (1.1) in group 2). This improvement in exercise ejection fraction and wall motion was maintained at later follow up with no significant deterioration in either variable and a clearly sustained improvement in ejection fraction (60 (10)% in group 1 and 51 (10)% in group 2) and wall motion score (0.2 (0.2) in group 1 and 1.3 (0.8) in group 2) compared with values before angioplasty. The initial improvement in left ventricular function on exercise after successful angioplasty was maintained for at least 9-24 months both in patients with previous myocardial infarction and in those without.
- Published
- 1990
- Full Text
- View/download PDF
4. Can the extent of coronary artery disease be predicted from thallium-201 myocardial images?
- Author
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McKillop JH, Murray RG, Turner JG, Bessent RG, Lorimer AR, and Greig WR
- Subjects
- Adult, Coronary Disease pathology, Female, Humans, Male, Middle Aged, Radiography, Radionuclide Imaging, Coronary Disease diagnostic imaging, Heart diagnostic imaging, Physical Exertion, Radioisotopes, Thallium
- Abstract
The accuracy with which the extent of coronary artery disease can be predicted from stress thallium-201 myocardial images has been assessed in 81 patients with chest pain. Whereas the appearance of the myocardial images was both a sensitive means of detecting coronary artery disease (images abnormal in 43 of 47 patients with abnormal coronary arteriograms) and specific in excluding it (images normal in 31 of 34 patients with normal arteriograms), there was poor correlation between the extent of disease predicted from the Tl-201 images and the findings at arteriography. It is concluded that although stress Tl-201 myocardial imaging is a useful method for the noninvasive diagnosis of coronary artery disease, it cannot be relied upon to predict the number of abnormal vessels.
- Published
- 1979
5. Comparison of 12-lead and computer-analysed 3 orthogonal lead electocardiogram in coronary artery disease.
- Author
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Murray RG, Lorimer AR, Dunn FG, Macfarlane PW, Hutton I, and Lawrie TD
- Subjects
- Adult, Electrocardiography instrumentation, Evaluation Studies as Topic, Female, Humans, Male, Middle Aged, Coronary Disease diagnosis, Diagnosis, Computer-Assisted, Electrocardiography methods
- Abstract
The computer-analysed 3 orthogonal lead system ("3-lead ECG") provides a rapid and consistent interpretation of the electrocardiogram. In 102 patients undergoing selective coronary arteriography, the ability of such a system to predict the presence of absence of coronary artery disease and the site of myocardial ischaemia was compared with that of the conventional scalar electrocardiogram interpreted by cardiologists ("12-lead ECG"). Each system predicted the site of myocardial ischaemia with equal accuracy. The 3-lead ECG was a more sensitive index (3-lead ECG sensitivity=77%; 12-lead ECG sensitivity=70%) but less specific (3-lead ECG specificity=74%; 12-lead ECG specificity=78%). In coronary artery disease, the predictive "index of merit" for the 3-lead ECG was 0-51, compared with 0-48 for the 12-lead ECG. These results provide further justification for the routine use of the 3 orthogonal lead electrocardiogram.
- Published
- 1976
- Full Text
- View/download PDF
6. Bayesian analysis of stress thallium-201 scintigraphy.
- Author
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Murray RG, McKillop JH, Bessent RG, Hutton I, Lorimer AR, and Lawrie TD
- Subjects
- Bayes Theorem, Female, Humans, Male, Middle Aged, Radionuclide Imaging, Coronary Disease diagnostic imaging, Physical Exertion, Radioisotopes, Thallium
- Abstract
The variation of the diagnostic value of stress Tl-201 scintigraphy with prevalence of coronary heart disease (CHD) in the population has been investigated using Bayesian reasoning. From scintigraphic and arteriographic data obtained in 100 consecutive patients presenting with chest pain, the sensitivity of stress Tl-201 scintigraphy for the detection of significant CHD was 90% and the specificity was 88%. From Bayes' Theorem, the posterior probability of having CHD for a given test result was calculated for prevalences of CHD ranging from 1% to 99%. The discriminant value of stress Tl-201 scintigraphy was best when the prevalence of CHD lay between 30% and 70% and maximum for a prevalence of 52%. Thus, stress Tl-201 scintigraphy would be an unsuitable diagnostic test where the prior probability of CHD is low, e.g., population screening programmes, and would add little where the clinical probability of having CHD is already high. However, where the prior probability of having CHD is intermediate stress Tl-201 scintigraphy may provide valuable diagnostic information.
- Published
- 1981
- Full Text
- View/download PDF
7. Evaluation of thallium-201 exercise scintigraphy in coronary heart disease.
- Author
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Murray RG, McKillop JH, Bessent RG, Turner JG, Lorimer AR, Hutton I, Greig WR, and Lawrie TD
- Subjects
- Adult, Angiocardiography, Evaluation Studies as Topic, Exercise Test, Female, Humans, Male, Middle Aged, Radioisotopes, Radionuclide Imaging, Thallium, Coronary Disease diagnostic imaging
- Published
- 1979
- Full Text
- View/download PDF
8. Percutaneous transluminal coronary angioplasty in patients with reduced left ventricular ejection fraction: effects on myocardial perfusion and left ventricular response to exercise.
- Author
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Singh A, Chandler S, Pears D, Perry R, Murray RG, and Shiu MF
- Subjects
- Coronary Disease diagnostic imaging, Coronary Disease physiopathology, Female, Humans, Male, Middle Aged, Myocardial Reperfusion, Radionuclide Imaging, Retrospective Studies, Angioplasty, Balloon, Coronary Circulation, Coronary Disease therapy, Exercise Test, Stroke Volume
- Abstract
Many patients with coronary artery disease treated by percutaneous transluminal coronary angioplasty (PTCA) have a history of previous myocardial injury resulting in a reduced left ventricular ejection fraction (EF). The effects of successful PTCA on myocardial perfusion and left ventricular function in these patients were compared to treatment in patients with normal left ventricular EF. There were 21 patients with a normal EF (mean EF 59 +/- 2%) (Group I) and 15 patients with reduced EF (mean EF 43 +/- 1%) (Group II). Before PTCA a similar degree of reversible myocardial ischemia was present on thallium scintigraphy. At peak exercise left ventricular EF in the Group I patients decreased by 4 +/- 1% compared to 8 +/- 1% in Group II. At one month following successful PTCA there was resolution of reversible myocardial ischemia in both groups. No changes in EF at rest were observed. At the same level of exercise as before PTCA the mean EF was 5 +/- 1% higher than the pretreatment value in Group I and 10 +/- 1% higher in Group II. Thus in this study reversible myocardial ischemia was associated with severe compromise in the left ventricular response to exercise which was substantially improved by PTCA.
- Published
- 1989
- Full Text
- View/download PDF
9. Diagnostic exercise testing in 104 patients over 65 years of age.
- Author
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Glover DR, Robinson CS, and Murray RG
- Subjects
- Aged, Electrocardiography, Exercise Test, Female, Humans, Male, Pain, Prognosis, Thorax, Coronary Disease diagnosis, Physical Exertion
- Abstract
Since 1979 we have carried out symptom limited exercise stress tests for the diagnosis of chest pain in 104 patients, 61 male, 43 female, over 65 years of age; mean age 68 +/- 3 years. An upright bicycle ergometer was used for 64 tests, a treadmill for 38 tests and a supervised walk for 2 patients unable to undergo formal exercise testing. A positive result of greater than or equal to 1 mm of ST depression was recorded in 45% of patients; males 57%, females 28% (P less than 0.01). Bicycle and treadmill tests were equally likely to produce a positive result; bicycle 43%, treadmill 50% (NS). The limiting symptom was chest pain in 43%, dyspnoea in 26% and fatigue in 30% of patients. No serious arrhythmias or collapses occurred. During a mean follow up to 24 +/- 18 months 13 patients died. A positive exercise test was associated with a significantly increased risk of cardiac death; 8 of 47 patients with positive tests died compared with 1 of 57 patients with negative or equivocal tests (P less than 0.02). The remaining 4 deaths were due to malignancy. Exercise testing can thus be safely performed in elderly subjects with the expectation of a high diagnostic yield. A positive result confers a poor prognosis.
- Published
- 1984
- Full Text
- View/download PDF
10. Mistaking Coxsackie infection for coronary disease.
- Author
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Slater SD, Bell EJ, Murray RG, and Mitchell AA
- Subjects
- Adult, Antibodies, Viral analysis, Diagnostic Errors, Electrocardiography, Enterovirus immunology, Female, Humans, Male, Coronary Disease diagnosis, Coxsackievirus Infections diagnosis
- Published
- 1980
- Full Text
- View/download PDF
11. Pilot's hearts.
- Author
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McKillop JH, Murray RG, and Turner JG
- Subjects
- Humans, Radionuclide Imaging, Aerospace Medicine, Coronary Disease diagnostic imaging
- Published
- 1978
- Full Text
- View/download PDF
12. Relation between extent of coronary artery disease and severity of hyperlipoproteinaemia.
- Author
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Murray RG, Tweddel A, Third JL, Hutton I, Hillis WS, Lorimer AR, and Lawrie TD
- Subjects
- Age Factors, Cholesterol blood, Coronary Disease blood, Coronary Disease diagnostic imaging, Humans, Lipoproteins, HDL blood, Lipoproteins, LDL blood, Lipoproteins, VLDL blood, Male, Radiography, Triglycerides blood, Coronary Disease complications, Hyperlipidemias complications
- Abstract
Lipoprotein analyses were performed in 133 male patients and were correlated with the coronary arteriographic findings. The prevalence of hyperlipoproteinaemia was significantly higher in those patients with coronary artery disease (P less than 0-02). In addition, the more extensive the degree of coronary artery pathology the higher were the plasma concentrations of total cholesterol, triglyceride, and low density lipoprotein (LDL) cholesterol. Hyperlipoproteinaemia was more prevalent in the younger patients with coronary artery disease (P less than 0-02).
- Published
- 1975
- Full Text
- View/download PDF
13. Silent ischaemia following myocardial infarction: frequency, characteristics and prognosis.
- Author
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Fox JP, Beattie JM, Salih MM, Davies MK, Littler WA, and Murray RG
- Subjects
- Cohort Studies, Exercise Test, Female, Heart Rate, Humans, Male, Middle Aged, Prognosis, United Kingdom, Coronary Disease complications, Myocardial Infarction complications
- Abstract
Pre-discharge exercise tests were performed in 359 survivors of an acute myocardial infarction to determine the frequency, characteristics and prognostic implications of silent ischaemia. Tests were negative in 152 patients (42%), silent ischaemia was observed in 103 (29%) and painful ischaemia in 82 (23%). Heart rates at the development of ischaemia and the final double products were similar in both ischaemic groups but patients with silent ischaemia were able to exercise for longer (13.1 +/- 0.5 min) than those with painful ischaemia (9.3 +/- 0.5 min; P less than 0.0001). The 12 month mortality rose from 2% in patients with a negative test, to 4% in those with silent ischaemia and to 8% in those with painful ischaemia. Re-infarction rates increased similarly across the groups (3%, 8% and 18% respectively). Patients with silent ischaemia subsequently developed angina more frequently (47%) than those with negative tests (16%; P less than 0.001). These results suggest that exercise-induced silent ischaemia following myocardial infarction was common, occurring in 29% of patients. Although the final myocardial oxygen consumption was similar in both ischaemic groups those with silent ischaemia were able to exercise for longer. Finally silent ischaemia conferred an intermediate risk of death or re-infarction and was a strong predictor of subsequent angina pectoris.
- Published
- 1988
- Full Text
- View/download PDF
14. The clinical role of thallium-201 scintigraphy in the management and prognosis of coronary artery disease.
- Author
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Gammage MD, Murray DP, Rafiqi E, and Murray RG
- Subjects
- Adult, Aged, Exercise Test, Female, Humans, Male, Middle Aged, Prognosis, Radiography, Radionuclide Imaging, Coronary Disease diagnostic imaging, Radioisotopes, Thallium
- Abstract
The clinical impact of thallium-201 (Tl-201) scintigraphy in coronary artery disease was reviewed in 162 consecutive patients referred for routine investigation. Normal Tl-201 images were obtained in 86 of the 102 studies undertaken for diagnostic purposes. Eighty-one (94%) of the 86 were spared diagnostic coronary arteriography; 5 proceeded to coronary arteriography for persistent symptoms (1 had double vessel disease, 2 had single vessel disease only, 2 had normal arteriograms). Conversely, coronary arteriography was normal in 2 of 16 patients (12.5%) with unequivocal image defects. Tl-201 scintigraphy was performed as a functional complement to coronary arteriography in 60 patients, influencing the decision for surgery in 36 and determining the presence or absence of myocardial ischaemia in 24 patients with equivocal coronary arteriograms. Normal data were obtained in 9 patients. Of the 95 patients with normal Tl-201 scintigrams, only 5 (5.2%) required further investigations or intervention (4 arteriograms, 1 coronary angioplasty) over a follow-up period of 18 +/- 1 months, none suffered myocardial infarction and none died. There were no deaths in either the diagnostic or complementary group, irrespective of the result of the Tl-201 scintigram, during the mean follow-up period of 18 months. These data confirm both the valuable role of Tl-201 scintigraphy in the management of patients with suspected or proven coronary artery disease and the excellent prognostic value of a normal Tl-201 scintigram.
- Published
- 1986
- Full Text
- View/download PDF
15. Cold pressor induced changes in regional left ventricular wall motion: specific but insensitive for coronary artery disease.
- Author
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McKillop JH, Tweddel AC, Martin W, Clark RS, Murray RG, and Hutton I
- Subjects
- Adult, Coronary Disease physiopathology, Evaluation Studies as Topic, Female, Heart Rate, Heart Ventricles physiopathology, Humans, Male, Middle Aged, Radionuclide Imaging, Sodium Pertechnetate Tc 99m, Cardiac Output, Cold Temperature, Coronary Disease diagnostic imaging, Coronary Vessels diagnostic imaging, Stroke Volume
- Abstract
The incidence of new regional abnormalities of left ventricular wall motion induced by a peripheral cold stimulus has been examined in 75 patients who all underwent coronary arteriography. When analysis was carried out from a cine loop display a new wall motion abnormality had a sensitivity of 12% and a specificity of 100% for coronary artery disease. From stroke volume images the sensitivity was 35% and the specificity 87%. It is concluded that cold pressor induced wall motion changes are too insensitive to be a useful method of screening for coronary artery disease.
- Published
- 1984
- Full Text
- View/download PDF
16. Magnesium metabolism in patients with coronary heart disease.
- Author
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Boddy K, Robertson I, Mahaffy ME, Katoch DS, Murray RG, Dunn FG, and Hutton I
- Subjects
- Adult, Angina Pectoris metabolism, Body Weight, Humans, Magnesium urine, Male, Middle Aged, Coronary Disease metabolism, Magnesium metabolism
- Abstract
1. The oral absorption of magnesium, its myocardial uptake and exchangeable magnesium have been studied in patients with coronary heart disease and controls using the radioactive isotope magnesium-28. 2. No significant difference in oral absorption or myocardial uptake was found between patients and controls. 3. The exchangeable magnesium per kg body weight was significantly lower in the patients than in the controls.
- Published
- 1978
- Full Text
- View/download PDF
17. Thallium 201 exercise testing in coronary artery disease.
- Author
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Murray RG, McKillop JH, Bessent RG, Greig WR, and Lorimer AR
- Subjects
- Adult, Cardiac Catheterization, Coronary Angiography, Female, Humans, Male, Middle Aged, Radionuclide Imaging, Coronary Disease diagnostic imaging, Heart diagnostic imaging, Physical Exertion, Radioisotopes, Thallium
- Published
- 1978
18. Myocardial salvage following elective angioplasty for total coronary occlusion.
- Author
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Singh A, Murray RG, Chandler S, and Shiu MF
- Subjects
- Aged, Angina Pectoris etiology, Cineangiography, Coronary Angiography, Coronary Disease complications, Coronary Vessels diagnostic imaging, Humans, Male, Radionuclide Imaging, Angioplasty, Balloon, Coronary Disease therapy
- Abstract
A 65-year-old man with unstable angina had a critical left anterior descending coronary artery stenosis which progressed to total occlusion, without evidence of acute myocardial infarction. Thallium imaging revealed defects in the distribution of the left anterior descending coronary artery on exercise and redistribution, 4 h later. 99mTc radionuclide angiography showed a fall in left ventricular ejection fraction on exercise, and contrast cineangiography showed an extensive area of akinesia. Percutaneous transluminal coronary angioplasty was successful without any complications. Repeat radionuclide studies demonstrated improvement of both myocardial perfusion and function. Angiography at 1 year showed normal left ventricular contraction and no evidence of recurrent stenosis. The patient is free of angina, on no medication 2 years after angioplasty. This case illustrates the feasibility of myocardial salvage by elective coronary angioplasty in patients with unstable angina total coronary occlusion.
- Published
- 1987
- Full Text
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19. Are the clinical benefits of oral prenalterol in ischaemic heart failure due to beta blockade? A six month randomised double blind comparison with placebo.
- Author
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Glover DR, Wathen CG, Murray RG, Petch MC, Muir AL, and Littler WA
- Subjects
- Adrenergic beta-Agonists adverse effects, Adult, Aged, Blood Pressure drug effects, Clinical Trials as Topic, Double-Blind Method, Exercise Test, Female, Heart Failure etiology, Heart Failure physiopathology, Heart Rate drug effects, Humans, Male, Middle Aged, Practolol adverse effects, Practolol therapeutic use, Prenalterol, Random Allocation, Adrenergic beta-Agonists therapeutic use, Coronary Disease complications, Heart Failure drug therapy, Practolol analogs & derivatives
- Abstract
The clinical effects of the oral beta 1 partial agonist, prenalterol, were investigated in 37 patients (29 male, eight female; mean age 57 years) with chronic ischaemic left ventricular failure using a placebo controlled randomised double blind protocol over six months. All patients were limited by dyspnoea (New York Heart Association class III) despite treatment with digoxin and diuretics. Twenty eight patients completed the protocol. Moderate clinical improvement was seen in the prenalterol group, whereas there was little change in the placebo group. Bicycle exercise capacity increased over six months in the prenalterol and placebo groups but only achieved statistical significance for prenalterol when compared with baseline values. Maximum exercise heart rate was significantly reduced in the prenalterol group compared with placebo. Radionuclide left ventricular ejection fraction at rest and during exercise and cardiothoracic ratio showed no significant improvement in either group over six months. Prenalterol was well tolerated and produced no increase in frequency of angina or ventricular arrhythmias. Prenalterol produced clinical benefits and improved exercise tolerance while reducing exercise heart rate. A moderate placebo response was noted. The apparent beta blocking effect of prenalterol may be as important as the beta 1 agonist effect in producing these benefits. Prenalterol has, however, been withdrawn because of side effects in animals.
- Published
- 1985
- Full Text
- View/download PDF
20. Central haemodynamic changes during lower body positive pressure in patients with congestive cardiac failure.
- Author
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Bain RJ, Tan LB, Murray RG, Davies MK, and Littler WA
- Subjects
- Female, Humans, Male, Middle Aged, Pressure, Coronary Disease physiopathology, Gravity Suits, Heart Failure physiopathology, Hemodynamics physiology
- Abstract
Fifteen patients with moderately severe and severe chronic congestive heart failure were studied to determine the central haemodynamic results of short term increases in lower body positive pressure. Central haemodynamic variables were determined by Swan-Ganz thermodilution catheterisation and arterial cannulation. Graded increases in lower body positive pressure were applied to supine patients using Medical Anti-Shock Trousers (MAST). Increasing lower body positive pressure by 25 mm Hg and 55 mm Hg caused increases in mean right atrial pressure (6.0 to 13.2 to 17.9 mm Hg; p less than 0.001 and p less than 0.0001 respectively) and mean pulmonary artery pressure (26.8 to 35.5 to 41.3 mm Hg; p less than 0.05 and p less than 0.01 respectively). No significant changes were seen in left heart filling pressures or in pulmonary vascular resistance. Furthermore, there were no significant increases in indices of cardiac work (cardiac index, left ventricular stroke work index, right ventricular stroke work index or cardiac power output) despite the increased right heart filling pressures. These results show that in patients with longstanding severe congestive heart failure, short term increases in cardiac return may increase right heart pressures but do not appear to cause either beneficial or detrimental changes in left heart haemodynamic indices.
- Published
- 1989
- Full Text
- View/download PDF
21. The significance of the abnormal rest thallium-201 myocardial image in coronary artery disease.
- Author
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McKillop JH, Murray RG, Bessent RG, Turner JG, Greig WR, and Lorimer AR
- Subjects
- Adult, Angiography, Heart diagnostic imaging, Humans, Middle Aged, Radionuclide Imaging, Rest, Coronary Disease diagnostic imaging, Radioisotopes, Thallium
- Abstract
Rest Thallium-201 myocardial images were abnormal in 20 out of 40 patients with arteriographically proven coronary artery disease. The myocardial image appearances did not accurately reflect the extent of coronary artery disease present. However, in 35 of the 40 patients (88%) the presence or absence of abnormalities on the rest myocardial image correleted respectively with the presence or absence of abnormal wall motion at left ventriculography. Most rest image abnormalities could be attributed to previous myocardial infarction, but in six patients myocardial ischaemia was possibly the cause. These results suggest that though myocardial fibrosis is usually the cause of rest myocardial image abnormalities in coronary artery disease, this is not invariably so. The possible therapeutic implications are discussed.
- Published
- 1979
- Full Text
- View/download PDF
22. A comparison of visual and semiquantitative analysis of stress thallium-201 myocardial images in patients with suspected ischemic heart disease.
- Author
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McKillop JH, Murray RG, Turner JG, and Bessent RG
- Subjects
- Humans, Methods, Radionuclide Imaging, Television, Coronary Disease diagnostic imaging, Heart diagnostic imaging, Radioisotopes, Thallium
- Abstract
Three methods of analyzing stress thallium-201 myocardial images were performed on 79 patients with suspected coronary artery disease. The results of visual analysis of unprocessed Polaroid images, background subtracted and contrast enhanced computer generated color television images, and a semiquantitative regions-of-interest method were each compared to the coronary arteriographic findings in all patients. Analysis by the semiquantitative method achieved the highest accuracy for the classification of patients as either having or not having coronary artery disease. This method of interpreting myocardial images appears worthy of further study.
- Published
- 1980
- Full Text
- View/download PDF
23. Haemodynamic effects of prenalterol in patients with coronary heart disease.
- Author
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Hutton I, Murray RG, Boyes RN, Rae AP, and Hillis WS
- Subjects
- Blood Pressure drug effects, Heart Rate drug effects, Heart Ventricles physiopathology, Humans, Male, Myocardial Contraction drug effects, Myocardial Infarction physiopathology, Practolol pharmacology, Prenalterol, Adrenergic beta-Agonists pharmacology, Coronary Disease physiopathology, Hemodynamics drug effects, Practolol analogs & derivatives
- Abstract
The haemodynamic effects of prenalterol, a new selective beta-1 adrenoreceptor agonist, have been studied in patients with coronary heart disease. The drug was administered intravenously in a dosage of 0.5 to 2.5 micrograms/kg body weight to 20 patients undergoing coronary angiography and to 10 patients with a recent myocardial infarction, who had clinical evidence of left ventricular dysfunction. Left ventricular performance was enhanced in both groups of patients--left ventricular dP/dt (max) increased by 33 per cent and the systolic time intervals, pre-ejection period, and the ratio of pre-ejection period and left ventricular ejection shortened by 28 and 21 per cent, respectively. Cardiac output and stroke volume increased with no change in heart rate nor in left ventricular filling pressure. These results indicate that prenalterol enhances the contractile state of the myocardium without altering heart rate, and suggest that prenalterol could be of value in the management of patients with coronary heart disease, who have impaired left ventricular function.
- Published
- 1980
- Full Text
- View/download PDF
24. On-line computer-assisted exercise mapping.
- Author
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Murray RG, Watts MP, MacFarlane D, Irving A, Beattie JM, Tweddel AC, Lawrie TD, and MacFarlane PW
- Subjects
- Adult, Aged, Electrocardiography, Female, Humans, Male, Middle Aged, Coronary Disease diagnosis, Exercise Test, Online Systems
- Abstract
The ability of exercise ECG body surface mapping to detect the presence and distribution of coronary artery disease was investigated in 76 patients presenting with chest pain. The ECG data were recorded from 16 leads regularly placed over the left praecordium. All 16 leads were input simultaneously to a PDP8 computer and 8-second samples were stored at rest, at the termination of symptom-limited exercise, and in the recovery period. ST isopotential surface maps were subsequently constructed. The presence and praecordial projection of ST abnormality were related to the arteriographic distribution of coronary disease. The ECG data were abnormal in 56 of 58 patients with coronary disease and permitted the identification of left anterior descending artery disease in 49 of 53, right coronary artery disease in 39 of 43, and circumflex artery disease in 24 of 30. Mapping separated those with single vessel from those with multiple vessel disease in 91% of patients with coronary disease. These preliminary results suggest that exercise ECG body surface mapping may provide an attractive non-invasive approach to the investigation of patients with coronary disease.
- Published
- 1981
- Full Text
- View/download PDF
25. Does beta adrenergic blockade influence the prognostic implications of post-myocardial infarction exercise testing?
- Author
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Murray DP, Tan LB, Salih M, Weissberg P, Murray RG, and Littler WA
- Subjects
- Adrenergic beta-Antagonists therapeutic use, Adult, Coronary Disease complications, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction complications, Prognosis, Sensitivity and Specificity, Adrenergic beta-Antagonists pharmacology, Coronary Disease diagnosis, Exercise Test, Myocardial Infarction drug therapy
- Abstract
The influence of beta blockade on the ability of ST depression, during pre-discharge exercise testing, to predict coronary anatomy and subsequent complications was studied in 300 consecutive post-infarct patients, 125 of whom underwent cardiac catheterisation. At the time of exercise 62 patients were taking a beta blocker. The exercise test had a higher sensitivity in predicting multivessel disease in patients who were not taking beta blockers than in patients who were (95% v 76%). beta Blockade did not, however, influence the ability of the test to identify patients at risk of subsequent cardiac events (sensitivity 84% and 85% respectively). These results suggest that it is not necessary to stop treatment with beta blockers before predischarge exercise testing of patients who have had an acute myocardial infarction.
- Published
- 1988
- Full Text
- View/download PDF
26. Clinical Applications of Thallium-201 Myocardial Imaging
- Author
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Murray Rg and McKillop Jh
- Subjects
Radioisotopes ,business.industry ,Myocardial Infarction ,chemistry.chemical_element ,Coronary Disease ,General Medicine ,030204 cardiovascular system & hematology ,Myocardial imaging ,Angina Pectoris ,03 medical and health sciences ,0302 clinical medicine ,chemistry ,Humans ,Thallium ,Medicine ,030212 general & internal medicine ,Coronary Artery Bypass ,Radionuclide Imaging ,Nuclear medicine ,business - Published
- 1980
27. Cold pressor induced changes in regional left ventricular wall motion: specific but insensitive for coronary artery disease
- Author
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Murray Rg, Will Martin, A.C. Tweddel, James H. McKillop, I. Hutton, and R.S. Clark
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heart Ventricles ,Hemodynamics ,Coronary Disease ,Isotopes of technetium ,Coronary artery disease ,Heart Rate ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cardiac Output ,Radionuclide Imaging ,Left ventricular wall motion ,Sodium Pertechnetate Tc 99m ,business.industry ,Cold pressor test ,Stroke Volume ,General Medicine ,Stroke volume ,Middle Aged ,medicine.disease ,Coronary Vessels ,Peripheral ,Cold Temperature ,Blood pressure ,Evaluation Studies as Topic ,Cardiology ,Female ,business - Abstract
The incidence of new regional abnormalities of left ventricular wall motion induced by a peripheral cold stimulus has been examined in 75 patients who all underwent coronary arteriography. When analysis was carried out from a cine loop display a new wall motion abnormality had a sensitivity of 12% and a specificity of 100% for coronary artery disease. From stroke volume images the sensitivity was 35% and the specificity 87%. It is concluded that cold pressor induced wall motion changes are too insensitive to be a useful method of screening for coronary artery disease.
- Published
- 1984
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