1. Therapeutic approaches in the stimulation of the coronary collateral circulation.
- Author
-
Degen A, Millenaar D, and Schirmer SH
- Subjects
- Angiogenesis Inducing Agents therapeutic use, Animals, Cell- and Tissue-Based Therapy methods, Coronary Artery Disease physiopathology, Counterpulsation methods, Cytokines therapeutic use, Disease Models, Animal, Humans, Neovascularization, Physiologic physiology, Collateral Circulation physiology, Coronary Artery Disease therapy, Coronary Circulation physiology
- Abstract
Arteriogenesis as a way to restore blood flow after arterial occlusion has been under investigation for the treatment of coronary artery disease (CAD) for decades. Therapeutic approaches so far have included delivery of cytokines and growth factors as well as mechanical stimulation such as external counterpulsation. As knowledge on the mechanisms of arteriogenesis expanded, new therapeutic approaches have emerged. This review summarizes recent attempts to stimulate the growth of the coronary vasculature and discusses their potential in clinical application. This article also delivers an overview of current studies and trials on coronary arteriogenesis.
- Published
- 2014
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