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Objective To analyze the vascular lesion of coronary artery, Carotid artery and dorsalis pedis artery by 64-section Dual source CT (64-DSCT) and Ultrasonography in aged type 2 diabetes mellitus (T2DM) with coronary heart disease (CHD). Methods 129 patients with coronary heart disease (CHD) were divided into two groups: 69 cases in elderly CHD group, and 60 cases in elderly T2DM with CHD group. The vascular lesion of coronary artery, Carotid artery and dorsalis pedis artery were measured by 64-DSCT and ultrasonography and compared between two groups. Results Compared with the elderly CHD group, coronary vessel disease was mainly multiple branches in elderly T2DM with CHD group, the difference was statistically significant (P<0.05). The rate of the carotid and dorsalis pedis plaque of elderly T2DM with CHD group were 81.6%and 55%, which were significantly higher than the elderly CHD group (65.2%and 39.1%), the difference was statistically significant (P<0.05). Carotid intimal-medial thickness (IMT) and plaque scores in elderly T2DM with CHD group were higher than the elderly CHD group. The plaque number of peripheral vascular in coronary lesions of three branches and two branches groups were higher than the single branch group, the difference was statistically significant (P<0.05). Conclusions The coronary lesions are mainly multivessel lesions in elderly T2DM with CHD patients. The Carotid and dorsalis pedis plaques are mainly vulnerable plaques in these patients. The more peripheral vascular plaque number, the more coronary lesion branches. [ABSTRACT FROM AUTHOR]

Objective To evaluate the vascular lesion of coronary artery by 64-section Dual source CT and analyze inflammatory mediators in aged type 2 diabetes mellitus (T2DM) with coronary heart disease (CHD), which can provide the diagnosis evidence for predicting the risk of coronary heart disease and the early identification of vulnerable patients. Methods Subjects were divided into two groups, there were 69 cases in elderly CHD group, 60 cases in elderly T2DM with CHD group. The vascular lesion of coronary artery was analyzed by 64-section Dual source CT. Meanwhile, the levers of creactive protein (CRP), Plasma adhesion molecule-1 (VCAM1), matrix metalloproteinases 9 (MMP-9), interleukin 6 (IL-6) and homocysteine (Hcy) were measured by ELISA. Results Compared with the elderly CHD group, the proportion of soft plaque was higher in elderly T2DM with CHD group, the difference was statistically significant (P<0.05).The levels of IL-6, VCAM1, MMP-9 and Hcy in elderly T2DM with CHD group were higher than elderly CHD group. The levels of CRP, IL-6, VCAM1 and Hcy in the patients with non-calcified plaque were higher than the patients with calcific plaque, the difference was statistically significant ( P < 0.05). Conclusion The 64-section Dual source CT coronary angiography can effectively detect coronary plaque composition. The composition of coronary plaque in elderly T2DM with CHD group are mainly soft plaque and mixed plaque. The serological markers of CRP, IL-6, VCAM1, Hcy can be used as a prediction index of plaque stability. [ABSTRACT FROM AUTHOR]