1. Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation.
- Author
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Diakonis VF, Kankariya VP, Kounis G, Pallikaris AI, Yoo SH, Pallikaris IG, and Kymionis GD
- Subjects
- Adult, Cell Count, Combined Modality Therapy, Cornea innervation, Corneal Keratocytes pathology, Endothelium, Corneal pathology, Female, Follow-Up Studies, Humans, Male, Microscopy, Confocal, Myopia pathology, Ophthalmic Nerve pathology, Prospective Studies, Refraction, Ocular physiology, Treatment Outcome, Visual Acuity physiology, Young Adult, Alkylating Agents administration & dosage, Cornea pathology, Keratomileusis, Laser In Situ, Lasers, Excimer therapeutic use, Mitomycin administration & dosage, Myopia surgery, Photorefractive Keratectomy
- Abstract
Purpose: To compare the visual and refractive outcomes and the corneal structural changes in myopic patients after surface refractive treatments (ie, photorefractive keratectomy [PRK] with adjuvant mitomycin-C [MMC] and epithelial laser in situ keratomileusis [epi-LASIK])., Setting: University of Crete, Heraklion, Crete, Greece., Design: Prospective comparative case series., Methods: One eye of consecutive myopic patients was randomly assigned to PRK-MMC, and the fellow eye was treated with epi-LASIK. Visual and refractive outcomes and corneal confocal microscopy findings were evaluated. All patients were examined preoperatively and 1, 3, 6, 12, and 24 months postoperatively., Results: Twenty-six eyes (13 patients) were included. The mean follow-up was 2.47 years ± 0.35 (SD) (range 1.64 to 2.93 years). In the PRK-MMC group, the mean preoperative spherical equivalent refraction was -3.84 ± 1.59 diopters (D) (range -1.5 to -8.7 D) and -0.21 ± 0.44 D (range -0.5 to 1.0 D) at the last follow-up and in the epi-LASIK group, -3.91 ± 1.48 D (range -1.5 to -8.5 D) and -0.18 ± 0.36 (range +0.5 to -0.5 D), respectively. Qualitative analysis of the subepithelial nerve plexus, haze development, and keratocyte distribution were similar in the 2 groups. There was no statistically significant difference in endothelial cell density between the groups throughout the follow-up (P>.05)., Conclusion: Epithelial LASIK and PRK-MMC gave similar visual, refractive, and corneal structural outcomes in patients with myopia for up to 2 years postoperatively., Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned., (Copyright © 2013 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
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