1. Spontaneous Ocular Abnormalities in Sprague-Dawley Rats
- Author
-
Haruhiro Yamashita, Minoru Sasaki, Kazunari Sugihara, Junya Morita, and Masaki Wakamatsu
- Subjects
Male ,medicine.medical_specialty ,Conjunctiva ,genetic structures ,Eye Diseases ,040301 veterinary sciences ,General Biochemistry, Genetics and Molecular Biology ,0403 veterinary science ,Rats, Sprague-Dawley ,Rodent Diseases ,Cornea ,Ophthalmology ,Sprague dawley rats ,Medicine ,Animals ,Eye Abnormalities ,Original Research ,Retina ,Slit lamp ,General Veterinary ,business.industry ,04 agricultural and veterinary sciences ,eye diseases ,Rats ,medicine.anatomical_structure ,Toxicity ,Female ,Choroid ,sense organs ,business ,Artery - Abstract
We collected historical control data derived from pretreatment ophthalmologic examinations of young (4 to 7 wk of age) Sprague–Dawley (Crl:CD[SD]) male, (2033, 42 lots) and female (1322, 32 lots) rats used in toxicity studies at our facility from 2004 through 2015. Ophthalmologic examination of male and female rats by using a binocular indirect ophthalmoscope and slit lamp revealed high incidences of corneal opacity (61% and 60%, respectively), lenticular opacity (43% and 47%), persistent hyaloid artery (21% and 17%), and retinal folds (27% and 27%). All other ocular abnormalities of the globe, conjunctiva, cornea, anterior chamber, lens, iris, vitreous, and choroid or retina occurred at incidences of less than 5%. Corneal opacities were localized mainly in the corneal nasal (38% and 37%) and paracentral (32% and 33%) areas, and lenticular opacities predominantly occurred in the nuclear area (31% and 34%). We then compared the incidences of spontaneous ocular abnormalities between the first (2004 through 2009) and second (2010 through 2015) 6-y periods. Corneal opacity and persistent hyaloid artery in male and female rats occurred more frequently during the second 6-y than during the first (corneal opacity, second period: male, 68%; female, 66%; corneal opacity, first period: 49% and 51%; persistent artery, second period, 26% and 23%; persistent artery, first period; 12% and 10%). These results support the importance of updating historical control data regularly and providing useful information for toxicologists and ophthalmologists to differentiate treatment-related changes from spontaneous lesions.
- Published
- 2020