13 results on '"Kato, Shunichi"'
Search Results
2. Stem cell transplantation for pediatric patients with adrenoleukodystrophy: A nationwide retrospective analysis in Japan.
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Kato, Koji, Yabe, Hiromasa, Shimozawa, Nobuyuki, Adachi, Souichi, Kurokawa, Mineo, Hashii, Yoshiko, Sato, Atsushi, Yoshida, Nao, Kaga, Makiko, Onodera, Osamu, Kato, Shunichi, Atsuta, Yoshiko, and Morio, Tomohiro
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STEM cell transplantation ,CHILD patients ,CORD blood transplantation ,ADRENOLEUKODYSTROPHY ,BONE marrow transplantation - Abstract
Background: Adrenoleukodystrophy (ALD) is an X‐linked recessive disorder and 30–40% of patients develop progressive cerebral neurodegeneration. For symptomatic ALD patients, allogeneic stem cell transplantation (SCT) is considered the standard treatment modality to stabilize or prevent the progression of neurological symptoms. Methods: We retrospectively analyzed the transplant outcomes of 99 pediatric patients with cerebral ALD in Japan. The conditioning regimens included Regimen A: fludarabine/melphalan/low‐dose total body irradiation (TBI) with brain sparing (n = 39), Regimen B; busulfan/cyclophosphamide ± others (n = 23), Regimen C: melphalan/total lymphoid irradiation/thoracoabdominal irradiation ± anti‐T lymphocyte globulin ± fludarabine (n = 27), and Regimen D: others (n = 10). Results: The 5‐year overall survival (OS) and event‐free survival (EFS) of all patients were 90.0% and 72.9%, respectively. The 5‐year OS was 100.0% for Regimen A, 91.1% for Regimen B, 84.4% for Regimen C, and 67.5% for Regimen D (p = 0.028). The 5‐year EFS was 78.3% for Regimen A, 78.0% for Regimen B, 70.4% for Regimen C, and 48.0% for Regimen D (p = 0.304). The OS marginally improved after 2007 compared with before 2006 (95.3% vs. 85.2%, p = 0.066), due to the improvement of cord blood transplantation (CBT) outcomes after 2007 compared with before 2006 (96.6% vs. 68.4%, p = 0.005). On magnetic resonance imaging of the brain, a reduced Loes score after SCT was only observed in one of the 15 bone marrow transplantation (BMT) patients, but in 5 of the 15 CBT patients (p = 0.173). Conclusions: Our study revealed that a reduced conditioning regimen with fludarabine/melphalan/low‐dose TBI provides better outcomes, and the results of CBT significantly improved after 2007. [ABSTRACT FROM AUTHOR]
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- 2022
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3. Combined impact of HLA-allele matching and the CD34-positive cell dose on optimal unit selection for single-unit cord blood transplantation in adults.
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Yabe, Toshio, Satake, Masahiro, Odajima, Takeshi, Watanabe-Okochi, Naoko, Azuma, Fumihiro, Kashiwase, Koichi, Matsumoto, Kayoko, Orihara, Takeshi, Yabe, Hiromasa, Kato, Shunichi, Kato, Koji, Kai, Shunro, Mori, Tetsuo, Morishima, Satoko, Takanashi, Minoko, Nakajima, Kazunori, Murata, Makoto, and Morishima, Yasuo
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CORD blood transplantation ,ADULTS ,TREATMENT effectiveness - Abstract
The combined effects of HLA-allele matching at six-loci (HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1) and CD34
+ cell dose on clinical outcomes were analyzed in 1,226 adult cases with single-unit unrelated cord blood transplantation. In the six-loci analysis, low HLA-allele matches did not significantly increase the overall mortality compared to higher matches, whereas in the five-loci analysis excluding HLA-DPB1, they caused a higher overall mortality (HR 1.42, p =.002), possibly due to the graft-versus-leukemia effect of HLA-DPB1 mismatches. A lower CD34+ cell dose (<.50 × 105 /kg) resulted in higher mortality and lower engraftment; these inferior outcomes were offset by high HLA-allele matches (7-10/10 match), while the inferior outcomes of low HLA-allele matches were improved by increasing the CD34+ cell dose. Consideration of the combined effects of the CD34+ cell dose and HLA matching may expand the options for transplantable units when HLA matching or the CD34+ cell dose is inadequate. [ABSTRACT FROM AUTHOR]- Published
- 2021
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4. Study for the improvement of umbilical cord blood sampling using a new trial apparatus.
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Masaoka, Naoki, Morooka, Masako, Nakajima, Yoshiyuki, Ogata, Hajime, Kodo, Hideki, and Kato, Shunichi
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CORD blood transplantation ,HEALTH outcome assessment ,RESEARCH funding ,T-test (Statistics) ,EQUIPMENT & supplies ,TREATMENT effectiveness ,DESCRIPTIVE statistics - Abstract
Aim The aim of this study was to evaluate the usefulness of the trial umbilical cord blood sampling bag for unrelated cord blood transplantation. Material and Methods Data were obtained from 100 vaginal deliveries. In 50 cases, umbilical cord blood ( UCB) was taken with the traditional Kawasumi type UCB sampling bag. In another 50 cases, UCB were taken with trial UCB sampling bag offered by NIPRO Co. We compared the sampling volume between the two groups. Furthermore, 10 cases in each group were matched by sampling volume; we examined the quality of UCB on the number and concentration of nucleated cells, mononuclear cells, CD34+ cells and colony-forming unit granulocyte macrophage and the numbers tested positive for bacteria. Results Whereas there were no significant differences in gestational weeks at sampling, the ratio of primipara women to multipara women, maternal age, and neonatal weight between the two groups, the sampling UCB volumes with the trial sampling bag were significantly higher than those with traditional sampling bags ( P < 0.05). In addition, this phenomenon was more significant in the latter part of the study period ( P < 0.05). On the other hand, there were no significant differences in the quality of UCB between the two groups. Conclusion Once clinicians have become accustomed to the trial UBC sampling bag, this method might be a useful method for collecting UCB for unrelated cord blood transplantation. [ABSTRACT FROM AUTHOR]
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- 2014
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5. Outcome of unrelated umbilical cord blood transplantation in 88 patients with primary immunodeficiency in Japan.
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Morio, Tomohiro, Atsuta, Yoshiko, Tomizawa, Daisuke, Nagamura-Inoue, Tokiko, Kato, Koji, Ariga, Tadashi, Kawa, Keisei, Koike, Kazutoshi, Tauchi, Hisamichi, Kajiwara, Michiko, Hara, Toshiro, and Kato, Shunichi
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UMBILICAL cord ,CORD blood transplantation ,IMMUNODEFICIENCY ,WISKOTT-Aldrich syndrome ,NEUTROPENIA ,MULTIVARIATE analysis ,COMPLICATIONS from organ transplantation ,PATIENTS ,SURGERY - Abstract
Summary [ABSTRACT FROM AUTHOR]
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- 2011
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6. The Japanese cord blood bank network experience with cord blood transplantation from unrelated donors for haematological malignancies: an evaluation of graft-versus-host disease prophylaxis.
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Nishihira, Hirokazu, Kato, Koji, Isoyama, Keiichi, Takahashi, Tsuneo A., Kai, Shunro, Kato, Shunichi, Takanashi, Minoko, Sato, Norihiro, Sato, Hiroyuki, Kitajima, Kohichi, Naoe, Tomoki, and Saito, Hidehiko
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CORD blood transplantation ,GRAFT versus host disease ,HEMATOLOGY - Abstract
Summary. Cryopreserved umbilical cord blood (CB) from unrelated donors can restore haematopoiesis after myeloablative therapy in patients with haematological malignancy. We investigated the clinical outcomes of CB transplantation (CBT) with special emphasis on graft-versus-host disease (GVHD) prophylaxis. Patients with haematological malignancies (n = 216) received intensive chemotherapy or immunosuppressive therapy, followed by transplantation of cryopreserved CB cells from unrelated donors. The clinical outcomes, i.e. haematological reconstitution, the incidence of acute or chronic GVHD, relapse and event-free survival (EFS), were evaluated. The estimated probability of neutrophil recovery was 88·2%. The median follow-up for the survivors was 557 d (range 21–1492 d). The overall and EFS rates were 32·6% and 25·5%, respectively, 3·5 years after transplantation. Multivariate analysis using Cox's proportional hazards model showed that high-risk disease status at CBT and single-drug GVHD prophylaxis were associated with worse 2-year EFS rates [P = 0·0013, relative risk (RR) 1·90, 95% confidence interval (CI) 1·28–2·81 and P = 0·0007, RR 1·91, 95% CI 1·31–2·79 respectively). Age at CBT had no significant influence on EFS. Cryopreserved CB from unrelated donors can restore haematopoiesis in patients with haematological malignancy. Although the incidence is low, the prophylaxis for acute GVHD is an important factor for survival of CBT from unrelated donors. A high rate of suitable donors was found, with a probability of 1 to every 18 CB units, when compared with human leucocyte antigen matching at other haematopoietic stem cell banks. [ABSTRACT FROM AUTHOR]
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- 2003
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7. Impact of Homozygous Conserved Extended HLA Haplotype on Single Cord Blood Transplantation: Lessons for Induced Pluripotent Stem Cell Banking and Transplantation in Allogeneic Settings.
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Morishima, Yasuo, Morishima, Satoko, Murata, Makoto, Arima, Nobuyoshi, Uchida, Naoyuki, Sugio, Yasuhiro, Takahashi, Satoshi, Matsuhashi, Yoshiko, Onizuka, Makoto, Eto, Tetsuya, Nagafuji, Koji, Onishi, Yasushi, Inoue, Masami, Atsuta, Yoshiko, Fukuda, Takahiro, Ichinohe, Tatsuo, Kato, Shunichi, and Kanda, Junya
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CORD blood transplantation , *INDUCED pluripotent stem cells , *STEM cell transplantation , *PLURIPOTENT stem cells , *TRANSPLANTATION of organs, tissues, etc. , *ALEMTUZUMAB , *CELL transplantation , *NEUTROPHILS - Abstract
• All assessable patients with donor HLA-homo to patient HLA-hetero pairs among 5017 single CBT pairs were engrafted neutrophil (38 pairs) and platelets (30 pairs) and revealed a tendency of high incidence of acute GVHD. • Ethnicity-specific conserved extended HLA haplotypes (CEHs) were invariably shared with the same donor HP in 35 pairs. • These findings imply the possibility that HLA-homo iPSC transplantation provides favorable engraftment and accordingly imply the merit of banking iPSC with homozygous major CEHs. Induced pluripotent stem cells (iPSCs) have been applied to clinical regenerative cell therapy. Recently, an iPSC banking system to collect HLA haplotype (HP) homozygous (homo) cells for iPSC transplantation in allogeneic settings was proposed, and tissue transplantation generated from iPSC through banking has just began. We analyzed 5017 single cord blood transplantation (CBT) pairs with HLA-A, -B, -C, -DRB1 allele typing data and found 39 donor HLA homo donor to patient HLA heterozygous (hetero) pairs. Of note, all 39 HLA homo to hetero pairs engrafted neutrophils, except 1 early death pair, and all 30 assessable pairs engrafted platelets. Acute graft-versus-host disease (GVHD) grades II to IV and grades III to IV occurred in 17 and 3 of 38 assessable pairs, respectively. Competing risk regression analysis revealed a favorable risk of neutrophil engraftment and higher risk of acute GVHD compared with HLA-matched CBTs. Thirty-seven of 39 homo to hetero pairs had conserved extended HLA HPs (HP-1, n = 18; HP-2, n = 8; HP-3, n = 7; HP-4, n = 4; HP-5, n = 1) that were ethnicity-specific, and at least 1 of 2 patient HLA-A, -B, -C, and -DRB1 alleles in each locus were invariably shared with the same donor HP in 35 pairs. These findings confirmed our preliminary results with 6 HLA homo CBTs, and a trend of high incidence of acute GVHD was newly observed. Importantly, they imply the possibility that HLA-homo iPSC transplantation provides favorable engraftment and accordingly imply the merit of banking iPSC with homozygous major conserved extended HLA HPs. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Double-Unit Cord Blood Transplantation after Myeloablative Conditioning for Patients with Hematologic Malignancies: A Multicenter Phase II Study in Japan
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Kai, Shunro, Wake, Atsushi, Okada, Masaya, Kurata, Mio, Atsuta, Yoshiko, Ishikawa, Jun, Nakamae, Hirohisa, Aotsuka, Nobuyuki, Kasai, Masaharu, Misawa, Mahito, Taniguchi, Shuichi, and Kato, Shunichi
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CORD blood transplantation , *HEMATOPOIETIC stem cell transplantation , *HEMATOLOGIC malignancies , *HEALTH outcome assessment , *TOTAL body irradiation , *CYCLOPHOSPHAMIDE - Abstract
Abstract: We analyzed the outcomes of 61 patients with hematologic malignancies who underwent double-unit cord blood transplantation (dCBT) after myeloablative conditioning performed as part of a prospective multicenter phase II study. The conditioning regimen for dCBT included total body irradiation, cyclophosphamide, and granulocyte colony-stimulating factor combined with cytosine arabinoside for myeloid malignancies and with total body irradiation and cyclophosphamide for lymphoid malignancies. The cumulative incidence of neutrophil engraftment after dCBT was 85% (95% confidence interval [CI], 73%-92%). All 51 of the patients who engrafted had complete chimerism derived from a single donor by day +60. Only the degree of HLA disparity in the host-versus-graft direction had an impact on unit dominance. The cumulative incidence of grade II-IV acute graft-versus-host disease was 25% (95% CI, 15%-37%), and that of chronic graft-versus-host disease was 32% (95% CI, 20%-44%). The 1-year cumulative incidence of relapse was 23% (95% CI, 13%-34%), and that of transplantation-related mortality was 28% (95% CI, 17%-39%). With a median follow-up of 41 months, event-free survival was 48% (90% CI, 37%-58%) at 1 year and 46% (90% CI, 35%-56%) at 3 years. Event-free survival at 3 years was 67% (95% CI, 46%-81%) for patients with standard risk and 29% (95% CI, 15%-45%) for those with advanced risk. This study suggests that dCBT after myeloablative conditioning is a promising alternative for adults and large children with hematologic malignancies who need stem cell transplantation but lack a suitable adult donor or an adequate single-unit cord blood graft. [Copyright &y& Elsevier]
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- 2013
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9. Comparison of Unrelated Cord Blood Transplantation and HLA-Mismatched Unrelated Bone Marrow Transplantation for Adults with Leukemia
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Atsuta, Yoshiko, Morishima, Yasuo, Suzuki, Ritsuro, Nagamura-Inoue, Tokiko, Taniguchi, Shuichi, Takahashi, Satoshi, Kai, Shunro, Sakamaki, Hisashi, Kouzai, Yasushi, Kobayashi, Naoki, Fukuda, Takahiro, Azuma, Hiroshi, Takanashi, Minoko, Mori, Takehiko, Tsuchida, Masahiro, Kawase, Takakazu, Kawa, Keisei, Kodera, Yoshihisa, and Kato, Shunichi
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CORD blood transplantation , *HLA histocompatibility antigens , *BONE marrow transplantation , *HEALTH outcome assessment , *ACUTE leukemia , *MYELODYSPLASTIC syndromes , *GRAFT versus host disease - Abstract
Recent advances in unrelated cord blood transplantation (UCBT) and high-resolution typing of human leukocyte antigen (HLA) from an unrelated donor have increased choices in alternative donor/stem cell source selection. We assessed HLA-mismatched locus-specific comparison of the outcomes of 351 single-unit UCB and 1,028 unrelated bone marrow (UBM) adult recipients 16 years old or older at the time of transplantation who received first stem cell transplantation with myeloablative conditioning for acute leukemia or myelodysplastic syndromes. With adjusted analyses, HLA 0 to 2 mismatched UCBT showed similar overall mortality (relative risk [RR] = 0.85, 95% confidence interval [CI], 0.68-1.06; P = .149) compared with that of single-HLA-DRB1-mismatched UBMT. UCBT showed inferior neutrophil recovery (RR = 0.50, 95% CI, 0.42-0.60; P < .001), lower risk of acute graft-versus-host disease (RR = 0.55, 95% CI, 0.42-0.72; P < .001), and lower risk of transplantation-related mortality (RR = 0.68, 95% CI, 0.50-0.92; P = .011) compared with single-HLA-DRB1-mismatched UBMT. No significant difference was observed for risk of relapse (RR = 1.28, 95% CI, 0.93-1.76; P = .125). HLA 0 to 2 antigen-mismatched UCBT is a reasonable second alternative donor/stem cell source with a survival outcome similar to that of single-HLA-DRB1-mismatched or other 7 of 8 UBMT. [Copyright &y& Elsevier]
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- 2012
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10. Intrabone Marrow Transplantation of Unwashed Cord Blood Using Reduced-Intensity Conditioning Treatment: A Phase I Study
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Okada, Masaya, Yoshihara, Satoshi, Taniguchi, Kyoko, Kaida, Katsuji, Ikegame, Kazuhiro, Kato, Ruri, Tamaki, Hiroya, Inoue, Takayuki, Soma, Toshihiro, Kai, Shunro, Kato, Shunichi, and Ogawa, Hiroyasu
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CORD blood , *BONE marrow transplantation , *GRAFT versus host disease , *STEM cell transplantation , *NEUTROPHILS , *BONE grafting - Abstract
The outcome of cord blood transplantation following reduced-intensity conditioning is suboptimal because of fatal infection triggered by prolonged neutropenia and graft-versus-host disease (GVHD) in addition to graft rejection. Intrabone marrow injection (IBMI) may improve the outcome by providing better hematopoietic engraftment and less GVHD. We therefore evaluated IBMI safety in reduced-intensity stem cell transplantation. Furthermore, we used unwashed cord blood to avoid stem cell loss. Ten patients (median age = 61 years old) were enrolled. Cord blood cells were thawed at the bedside and injected into 4 iliac bone sites (2 at each hemipelvis). The procedure was well tolerated with no injection-related complications. Nine patients achieved donor engraftment. The median time to neutrophil recovery (>0.5 × 109/L) was 17 days, and platelet recovery was achieved in 8 patients. Early full donor chimerism was achieved (median of 15 and 20 days in T cells and myeloid cells, respectively). Three of 9 evaluable patients developed grade II to III GVHD, and 5 of 10 patients died of treatment-related toxicities. The probability of survival at 1 year was 46.7%. IBMI of unwashed cord blood following reduced-intensity conditioning is safe, well tolerated, and may lead to an increased donor engraftment rate. [ABSTRACT FROM AUTHOR]
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- 2012
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11. Cord Blood Transplantation from Unrelated Donors for Children with Acute Lymphoblastic Leukemia in Japan: The Impact of Methotrexate on Clinical Outcomes
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Kato, Koji, Yoshimi, Ayami, Ito, Etsuro, Oki, Kentaro, Hara, Juinichi, Nagatoshi, Yoshihisa, Kikuchi, Akira, Kobayashi, Ryoji, Nagamura-Inoue, Tokiko, Kai, Shunro, Azuma, Hiroshi, Takanashi, Minoko, Isoyama, Keiichi, and Kato, Shunichi
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CORD blood , *ORGAN donors , *LYMPHOBLASTIC leukemia in children , *METHOTREXATE , *STEM cell transplantation , *HEALTH outcome assessment , *MEDICAL statistics - Abstract
Cord blood transplantation (CBT) from an unrelated donor is recognized as one of the major treatment modalities in allogeneic stem cell transplantation (SCT) for children with hematologic malignancies. We analyzed the clinical outcomes of CBT for children with acute lymphoblastic leukemia (ALL) in Japan and identified the risk factors for the transplant outcomes. From 1997 to 2006, 332 children with ALL underwent CBT from unrelated donors, 270 of which had no prior transplant. Their disease statuses at transplant were first complete remission (CR) (n = 120), second CR (n = 71), and more advanced stages (n = 75). As preconditioning for SCT, total body irradiation (TBI) was given to 194 patients and, for the prophylaxis of graft-versus-host disease (GVHD), methotrexate (MTX) was given to 159 patients. The cumulative incidents of neutrophil and platelet recovery (>20 K) were 88.5% and 78.4%, respectively. The incidents of grade II-IV, III-IV acute GVHD (aGVHD), and chronic GVHD (cGVHD) were 45.6%, 20.4%, and 19.2%, respectively, and treatment-related mortality was 22.6%. The 5-year event-free survival (EFS) and overall survival (OS) at CR1, CR2, and advanced status were 47.4%, 45.5%, 15.0%, and 63.7%, 59.7%, and 20.7%, respectively. Multivariate analysis revealed that MTX with calcineurin inhibitor (CNI) was associated with decreased incidence of grade II-IV GVHD (CNI alone: hazard ratio [HR] = 1.74, 95% confidence interval [CI] = 1.06-2.83, P = .027; CNI + prednisolone (PSL), HR = 1.61, 95% CI = 1.03-2.50, P = .036), III-IV aGVHD (CNI alone: HR = 3.02, 95% CI = 1.55-5.91, P = 0.001; CNI + PSL, HR = 1.89, 95% CI = 0.93-3.83, P = .078), or cGVHD (CNI alone: HR = 1.78, 95% CI = 0.83-3.82, P = .143; CNI + PSL, HR = 2.44, 95% CI = 1.24-4.82, P = .01), compared with CNI alone or CNI + PSL. At an advanced stage of disease, GVHD prophylaxis with MTX + CNI is associated with improved OS compared with CNI alone (CNI alone: HR = 3.20, 95% CI = 1.43-7.15, P = .005; CNI + PSL, HR = 1.47, CI = 0.67-3.20, P = .332). Our retrospective study showed that CBT for children with ALL is feasible and GVHD prophylaxis with MTX + CNI is associated with significant favorable outcomes in prevention of aGVHD and cGVHD as well as survival advantage in advanced cases. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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12. Incidence and Risk Factors of Early Bacterial Infections after Unrelated Cord Blood Transplantation
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Yazaki, Makoto, Atsuta, Yoshiko, Kato, Koji, Kato, Shunichi, Taniguchi, Shuichi, Takahashi, Satoshi, Ogawa, Hiroyasu, Kouzai, Yasuji, Kobayashi, Takeshi, Inoue, Masami, Kobayashi, Ryoji, Nagamura-Inoue, Tokiko, Azuma, Hiroshi, Takanashi, Minoko, Kai, Shunro, Nakabayashi, Masao, and Saito, Hidehiko
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DISEASE risk factors , *BACTERIAL diseases , *CORD blood , *CELL transformation - Abstract
Abstract: Incidence and characteristics of early bacterial infection within 100 days after unrelated cord blood transplantation (UCBT) were assessed for 664 pediatric and 1208 adult recipients in Japan. Cumulative incidence of early bacterial infection at day 100 post-UCBT was 11% (95% confidence interval [CI], 8%-13%) for children and 21% (CI, 19%-24%) for adults (P < .0001). Early bacterial infection in adults had a significant impact on mortality (hazard ratio [HR] = 2.1, CI, 1.7-2.6; P < .0001), although no significant risk factors were identified. Multivariate analysis identified older age group (6-10, and 11-15 years versus 0-5 years of age) at transplant (HR = 2.0 and 2.7, CI, 1.1-3.5 and 1.4-4.9; P = .020 and .002, respectively) as an independent risk factor of early bacterial infection for children. Early bacterial infection in children did not have a significant impact on mortality when adjusted. Of 315 bacteremia, 74% were caused by Gram-positive microorganisms. Pneumonia occurred in 39 patients including 13 cases of Stenotrophomonas maltophilia pneumonia. Early bacterial infection had a negative effect on survival for adults and the median day of development was 10 days after transplant, suggesting that the prevention of bacterial infection in the very early post-UCBT phase is important. [Copyright &y& Elsevier]
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- 2009
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13. HLA-DPB1 Mismatch Induces Low Hematological Relapse and Beneficial Survival in Single Unit Cord Blood Transplantation.
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Yabe, Toshio, Azuma, Fumihiro, Kashiwase, Koichi, Matsumoto, Kayoko, Orihara, Takeshi, Yabe, Hiromasa, Kato, Shunichi, Kato, Koji, Kai, Shunro, Mori, Tetsuo, Morishima, Satoko, Satake, Masahiro, Takanashi, Minoko, Nakajima, Kazunori, and Morishima, Yasuo
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HLA histocompatibility antigens , *HEMATOLOGICAL oncology , *DISEASE relapse , *CORD blood transplantation , *CLINICAL trials - Published
- 2016
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