1. Copper-catalyzed alkene arylation with diaryliodonium salts.
- Author
-
Phipps RJ, McMurray L, Ritter S, Duong HA, and Gaunt MJ
- Subjects
- Catalysis, Alkenes chemistry, Benzene Derivatives chemistry, Copper chemistry, Onium Compounds chemistry
- Abstract
Alkenes and arenes represent two classes of feedstock compounds whose union has fundamental importance to synthetic organic chemistry. We report a new approach to alkene arylation using diaryliodonium salts and Cu catalysis. Using a range of simple alkenes, we have shown that the product outcomes differ significantly from those commonly obtained by the Heck reaction. We have used these insights to develop a number of new tandem and cascade reactions that transform readily available alkenes into complex arylated products that may have broad applications in chemical synthesis.
- Published
- 2012
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