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The effect of solvent has been investigated for the synthesis of bismuth gallate compounds, of which the water-based bismuth subgallate has been used as an active pharmaceutical ingredient (API) for over a century. Using methanol as a solvent, two new bismuth gallates were acquired: first a flexible 3-periodic metal–organic framework (MOF) forms, which transforms upon extended synthesis times into a layered 2-periodic coordination polymer of the same bismuth-to-gallate ratio. The structures were determined by three-dimensional electron diffraction. Synthesis in ethanol resulted in the formation of the MOF phase, but not the layered phase. The layered material of the methanol-based synthesis was used as a Lewis acid catalyst due to its higher stability, showing a comparatively quick and regiospecific conversion of styrene oxide to 2-methoxy-2-phenylethanol, indicating the presence of open metal sites in the material. The acquisition of bismuth gallate structures of varying periodicity highlights the prospect of acquiring novel MOFs and coordination polymers from the same components of APIs. [ABSTRACT FROM AUTHOR]

15 Loiseau, T., Serre, C., Huguenard, C., Fink, G., Taulelle, F., Henry, M., Bataille, T., Férey, G. Chem. Eur. J. 2004, 10, 1373-1382; https://doi.org/10.1002/chem.200305413. 26 Li, W.-J., Liu, J., Sun, Z.-H., Liu, T.-F., Lü, J., Gao, S.-Y., He, C., Cao, R., Luo, J.-H. Nat. 6 García-Sánchez, A., Gomez-Mendoza, M., Barawi, M., Villar-Garcia, I. J., Liras, M., Gándara, F., de la Peña O'Shea, V. A. J. Am. Chem. Soc. 2020, 142, 318-326; https://doi.org/10.1021/jacs.9b10261. 5 Lamagni, P., Miola, M., Catalano, J., Hvid, M. S., Mamakhel, M. A. H., Christensen, M., Madsen, M. R., Jeppesen, H. S., Hu, X.-M., Daasbjerg, K., Skrydstrup, T., Lock, N. Adv. Funct. [Extracted from the article]

Electron and powder diffraction were combined to elucidate the structure of the new coordination polymer [Sc2(FcDC)3] based on 1,1′-ferrocenedicarboxylate (FcDC2−), denoted as CAU-50. Remarkably, three different conformers of the very same linker molecule are observed, two of which serve as connectors for the scandium cations while one conformer acts as capping agent. [ABSTRACT FROM AUTHOR]

Bismuth subgallate has been used in wound and gastrointestinal therapy for over a century. The combination of continuous rotation electron diffraction and sample cooling finally revealed its structure as a coordination polymer. The structure provides insight regarding its formula, poor solubility, acid resistance and previously unreported gas sorption properties. [ABSTRACT FROM AUTHOR]