1. A New Complex Design of Fe (II) Isoleucine Dithiocarbamate as a Novel Anticancer and Antivirus against SARSCOV-2 (COVID-19).
- Author
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Irfandi R, Riswandi R, Raya I, Ahmad A, Fudholi A, Jarre S, Tirto Sari DR, Santi S, Wijaya RI, and Prihantono P
- Subjects
- Angiotensin-Converting Enzyme 2, Antiviral Agents pharmacology, Ferrous Compounds, Humans, Isoleucine, Ligands, Molecular Docking Simulation, Nitrogen, Oxygen, Spectroscopy, Fourier Transform Infrared, Sulfur, Antineoplastic Agents chemistry, Coordination Complexes pharmacology, COVID-19 Drug Treatment
- Abstract
Background: This study was carried out to synthesize a new complex of Fe(II) with isoleucine dithiocarbamate ligand and to determine its potential as an anticancer and antiviral agent for SARSCOV-2., Methods: The synthesized complexes were then characterized by UV-vis and FT-IR spectroscopy and their melting points. The value of the conductivity of the complex compound is also determined. Anti-cancer activity was tested in vitro and molecular docking. Its potential as an antiviral against SARSCOV-2 was also carried out by molecular docking. Pharmacokinetics/ADMET properties were also carried out on the complex., Result: Spectral results showed the successful synthesis of Fe(II) isoleucine dithiocarbamate complex. The complex produced UV-vis spectra at 268 and 575 nm, and the IR data at 399-599 cm-1 showed the coordination between the Fe(II) atoms with sulphur, nitrogen and oxygen of the isoleucine dithiocarbamate ligand. Fe(II) isoleucine dithiocarbamate had a cytotoxicity effect on the MCF-7 cell line (IC50 =613 µg/mL). The complex significantly caused morphological changes in the breast cancer cell line, finally leading to cell apoptosis., Conclusion: Cytotoxic test of Fe(II) isoleucine dithiocarbamate showed moderate anticancer activity on MCF-7 cancer cells and showed antiviral activity against SARSCOV-2 by interfering with spike glycoprotein -ACE2 receptors, and inhibiting major proteases and 3Clpro.
- Published
- 2022
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