1. Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants
- Author
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Talebian, Sepehr, Mendes, Bárbara, Conniot, João, Farajikhah, Syamak, Dehghani, Fariba, Li, Zhongyan, Bitoque, Diogo, Silva, Gabriela, Naficy, Sina, Conde, João, Wallace, Gordon G., NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centre for Toxicogenomics and Human Health (ToxOmics)
- Subjects
Materials Science(all) ,drug delivery ,medical Implants ,Chemical Engineering(all) ,Medicine (miscellaneous) ,biopolymers ,Physics and Astronomy(all) ,controlled release ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Engineering(all) - Abstract
Funding Information: S.T., B.M., and J.C. contributed equally to this work. The authors are grateful for funding received from the Australian Research Council Centre of Excellence program (Project Number CE 140100012). J.C. acknowledges the European Research Council Starting Grant (ERC‐StG‐2019‐848325). S.N. and F.D. acknowledge the financial support of Australian Research Council through DP200102164. Publisher Copyright: © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH. The deployment of structures that enable localized release of bioactive molecules can result in more efficacious treatment of disease and better integration of implantable bionic devices. The strategic design of a biopolymeric coating can be used to engineer the optimal release profile depending on the task at hand. As illustrative examples, here advances in delivery of drugs from bone, brain, ocular, and cardiovascular implants are reviewed. These areas are focused to highlight that both hard and soft tissue implants can benefit from controlled localized delivery. The composition of biopolymers used to achieve appropriate delivery to the selected tissue types, and their corresponding outcomes are brought to the fore. To conclude, key factors in designing drug-loaded biopolymeric coatings for biomedical implants are highlighted. publishersversion epub_ahead_of_print
- Published
- 2023