1. A comparison of a non-ionic dimer, iodixanol with a non-ionic monomer, iohexol in low dose intravenous urography.
- Author
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Skehan SJ, Rasmussen F, Gibney RG, Lindequist S, Moller-Nielsen S, Svaland MG, Kampenes VB, Bjartveit K, Greaney T, Carlsen SD, and Masterson J
- Subjects
- Adult, Aged, Contrast Media adverse effects, Double-Blind Method, Humans, Middle Aged, Prospective Studies, Sensitivity and Specificity, Triiodobenzoic Acids adverse effects, Urography methods, Contrast Media administration & dosage, Iohexol administration & dosage, Triiodobenzoic Acids administration & dosage, Urography standards
- Abstract
A prospective, double-blind study of 392 patients randomized into four groups was performed to establish whether diagnostic intravenous urograms could be obtained with a lower dose of iodine when using the dimeric, non-ionic contrast medium iodixanol compared with the monomeric, non-ionic iohexol. Patients received iodixanol or iohexol containing either 9 or 12 g of iodine (gI). The primary parameter was the diagnostic quality of the 6 min film, assessed in a blinded fashion, by consensus, by four radiologists. Iodixanol at both doses was diagnostic in over 90% of cases. Iohexol was only diagnostic in 74% (9 gI) and 81.8% (12 gI). Pairwise comparisons revealed that iodixanol 9 gI was significantly better than both iohexol 9 gI (p = 0.0005) and 12 gI (p = 0.014). No significant difference was present for different doses within the same contrast medium group. Iodixanol resulted in poorer bladder distension than iohexol. Iodixanol caused significantly less discomfort than iohexol.
- Published
- 1998
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