1. Effect of progestogen-only contraception on premenopausal fracture risk: a case-control study.
- Author
-
Kyvernitakis I, Kostev K, Thomasius F, Stumpf U, and Hadji P
- Subjects
- Adolescent, Adult, Case-Control Studies, Female, Humans, Incidence, Premenopause, Contraception, Progestins adverse effects
- Abstract
Our study demonstrated that progestogen-only oral and intrauterine contraceptives are not associated with fracture risk independent from age., Purpose: The use of progestogen-only contraception, resulting in a hypoestrogenic state, has been associated with impaired bone acquisition and increased fracture risk. The aim of this large population-based study was to assess the fracture risk in association with the use of progestogen-only contraceptives (progestogen-only pills (POPs) and progestogen-containing IUDs (LNG-IUD))., Methods: We identified 14,421 women between 16 and 55 years of age with a first-time diagnosis of fracture and matched them with 14,421 random controls using the Disease Analyzer Database., Results: The results of the first adjusted logistic regression model (ever use vs. never use of progestogen-only contraceptives) revealed that there was no significant association between the use of POPs (OR = 0.98, 95% CI 0.90-1.07, p = 0.657) or LNG-IUDs (OR = 0.99, 95% CI 0.81-1.21, p = 0.945) and fracture incidence. Also, in the second regression model, we observed no effect of duration of use of POPs (OR = 1.01, 95% CI 0.98-1.03, p = 0.672) or LNG-IUDs (OR = 0.94, 95% CI 0.87-1.02, p = 0.177) on fracture occurrence. We also observed no effect in different age groups., Conclusion: Our study results indicate that progestogen-only contraception (either POPs or LNG-IUPs) is not associated with fracture risk and may be considered a bone-safe option for adults and adolescents.
- Published
- 2020
- Full Text
- View/download PDF