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Abstract The North Qaidam ultra-high pressure (UHP) metamorphic belt in the northern Tibetan Plateau is considered as a typical Alpine-type UHP metamorphic belt due to the Early Paleozoic subduction of the Qaidam Block beneath the Qilian Block. The well-preserved Paleozoic metatexite migmatite, diatexite migmatite, felsic sheet/dyke and anatectic granite in the North Qaidam UHP metamorphic belt provide us with an excellent opportunity to study the generation, transport and final fate of crustal melt and geodynamic processes associated with orogenesis. Based on structural relationships, petrology, geochronology, whole-rock geochemistry and Sr Nd isotope data, the Early Paleozoic anatexis during oceanic subduction to continental collision in the North Qaidam UHP metamorphic belt can be further divided into three stages of development ~470 Ma, 446–428 Ma and 432–420 Ma. The first-stage granitic leucosomes are rich in K, poor in Na with low Sr/Y and enrichment of large ion lithophile elements (LILEs), which were probably derived from partial melting of ancient felsic gneiss in continental arc circumstances during oceanic subduction. The second-stage Na-rich leucosomes and tonalite plutons are characterized by high Na, Sr, Sr/Y and La/Yb and low heavy rare earth elements (HREEs), with positive ε Nd (t) values of 0.1–4.3 and zircon ε Hf (t) values of 8.3–10.2, similar to typical tonalite-trondhjemite-granodiorites (TTGs). These TTG-like magmas were produced through partial melting of newly emplaced gabbroic rocks with arc affinity under high-pressure (HP) granulite-facies conditions in a thickened lower crust during continental collision. The volumetrically significant migrated plutons evolved from TTG-like melt will become segments of continental crust and contribute to crustal growth, with partial residual products of HP granulite and/or garnet pyroxenite to the mantle by delamination. The third stage of anatexis was preserved in both migmatitic UHP gneiss and eclogite in the Xitieshan and Luliangshan terranes. The Kfs-rich felsic leucosomes inside UHP gneisses in the third stage are characterized by high alkali contents and low mafic component with FeO T + MgO + TiO 2 <2%. In trace element distribution diagrams, these Kfs-rich leucosomes exhibit parallel patterns to their host gneisses but lower element contents and slightly positive Eu and Sr anomalies. The Pl-rich leucosomes within the retrograde eclogite have geochemical features as follows: (1) rich in CaO, Na 2 O and poor in K 2 O, with Na 2 O/K 2 O ratios >2.0; (2) high La/Yb and Sr/Y, and low Y and HREEs; (3) high Al 2 O 3 and low Mg# values; and (4) enriched in LILEs(e.g., Rb, Ba, K, Sr, Pb) and poor in high field strength elements (HFSEs). Partial melting of UHP eclogite and felsic gneiss during the initial retrogression stage with Pl-rich and Kfs-rich leucosome formation was triggered by dehydration melting involving predominant zoisite and muscovite. The anatectic melts from partial melting of deeply subducted UHP gneiss have accumulated and migrated outside the deeply subducted crustal slice in the form of syn -collisional plutons. The melt evolution from the leucosomes produced at the early exhumation stage to syn-collisional granitoids produced at the late exhumation, might contribute greatly to the exhumation of the North Qaidam UHP metamorphic belt from mantle depths to the lower crustal levels. [ABSTRACT FROM AUTHOR]