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Background: Occupational skin diseases have led the occupational disease statistics in Europe for many years. Especially occupational allergic contact dermatitis is associated with a poor prognosis and low healing rates leading to an enormous burden for the affected individual and for society. Objectives: To present the sensitization frequencies to the most relevant allergens of the European baseline series in patients with occupational contact dermatitis (OCD) and to compare sensitization profiles of different occupations. Methods: The data of 16 022 patients considered having OCD after patch testing within the European Surveillance System on Contact Allergies (ESSCA) network between January 2011 and December 2020 were evaluated. Patients (n = 46 652) in whom an occupational causation was refuted served as comparison group. Results: The highest percentages of OCD were found among patients working in agriculture, fishery and related workers, metal industry, chemical industry, followed by building and construction industry, health care, food and service industry. Sensitizations to rubber chemicals (thiurams, carbamates, benzothiazoles) and epoxy resins were associated with at least a doubled risk of OCD. After a decline from 2014 onwards, the risks to acquire an occupation‐related sensitization to methyl(chloro)isothiazolinone (MCI/MI) and especially to methylisothiazolinone (MI) seem to increase again. Sensitization rates to formaldehyde were stable, and to methyldibromo glutaronitrile (MDBGN) slightly decreasing over time. Conclusions: Among allergens in the European Baseline Series, occupational relevance is most frequently attributed to rubber accelerators, epoxy resins and preservatives. [ABSTRACT FROM AUTHOR]

Background: Massage therapists are particularly exposed to constituents of massage preparations, wet work and mechanical strain and therefore, at high risk to develop occupational dermatitis (OD). Objectives: To describe the sensitization spectrum of massage therapists with OD. Patients and Methods: In a retrospective study, patch test data of patients with OD (128 massage therapists and 24 374 patients working in other professions) collected by the Network of Departments of Dermatology (IVDK, 2008–2020) were analysed. Results: Hand dermatitis (91.4%) and allergic contact dermatitis (34.4%) were common in massage therapists with OD. Most frequent were sensitizations to fragrances/essential oils which were found in 54 (42.2%) massage therapists and thus, more often than in other patients with OD. Concomitant positivity to several fragrances/essential oils was frequent. In 8 (14.8%) of the 54 massage therapists, sensitizations to fragrances/essential oils were not detected with the baseline series, but only with special fragrance series. Conclusions: Allergic contact dermatitis is common in massage therapists with OD and is mainly caused by fragrances and essential oils. Hence, massage therapists should be aware of this risk. When OD is suspected, not only the baseline series, but also special fragrance series should be patch tested in this occupational group. [ABSTRACT FROM AUTHOR]

Keywords: 2,4,6-Tris(dimethylaminomethyl)phenol; CAS 90-72-2; epoxy resin; patch testing; tris-DMP EN 2,4,6-Tris(dimethylaminomethyl)phenol CAS 90-72-2 epoxy resin patch testing tris-DMP 316 318 3 03/15/23 20230401 NES 230401 2,4,6-Tris(dimethylaminomethyl)phenol (tris-DMP; CAS No. 90-72-2) is a hardener/accelerator frequently used in epoxy resin systems (ERS), especially at low ambient temperature.[1] First cases of contact sensitization to tris-DMP have been observed at the Finnish Institute of Occupational Health (FIOH) around 1990.[2] Since then, contact sensitization to tris-DMP has been described in several case reports from various European countries.[1] In the FIOH, 14 cases of contact sensitization to tris-DMP have been registered from 1991 to 2013, rendering it the second most frequent sensitizer among epoxy resin hardeners.[1] Since 2016, tris-DMP is available as patch test preparation at 0.5% in pet. from Chemotechnique, Vellinge, Sweden. However, 9 out of 14 FIOH patients (64%) sensitized to tris-DMP, but only 3 of the 28 tris-DMP positive IVDK patients (11%), were painters. DISCUSSION Consistent with the FIOH data,[1] we found sensitizations to tris-DMP less frequently than sensitizations to MXDA, but with a similar frequency as sensitizations to IPDA. [Extracted from the article]

Of 131 patch-test positive patients, 24 (18.3%) reacted to both preparations, 98 (74.8%) to FMI only, and 9 (6.9%) to OM and not to FMI, although OM is a constituent of FMI. Keywords: allergic contact dermatitis; delayed reactions; fragrance; fragrance mix I; late reactions; oak moss absolute; patch test; patch test active sensitization EN allergic contact dermatitis delayed reactions fragrance fragrance mix I late reactions oak moss absolute patch test patch test active sensitization 54 57 4 12/17/21 20220101 NES 220101 Patch test reactions that become positive de novo at around day 7 (D7) are called "late" patch test reactions,1 and are frequently seen after patch testing neomycin, for example.2 Reactions beyond D7 ("very late reactions") may indicate active sensitization.1,3 However, very late reactions (2 to 4 weeks after patch testing) without being linked to active sensitization have also been observed.4-6 We were interested in very late reactions (beyond D7) in patch testing fragrance mix I (FMI) and oak moss absolute (OM). Regarding all positive reactions, 11/136 (8.1%) of FMI-positive patients and 11/45 (24.4%) of OM-positive patients showed very late reactions (Table 1). 1 TABLEResults of reading fragrance mix I (FMI) and oak moss absolute (OM) in n = 1789 patients at different points of time HT