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Background: 2‐Hydroxyethyl methacrylate (HEMA) was added to the European baseline series (EBS) in 2019. Few recent data are available on the frequency and relevance of positive reactions to this hapten. Objectives: To investigate the frequency and relevance of positive patch tests to HEMA in the EBS in a university hospital in Amsterdam, The Netherlands. Patients and Methods: Retrospective study in patients with positive patch tests to HEMA investigated between June 2019 and August 2023. Results: Of 2927 consecutive patients, 88 (79 women and 9 men; 3.0%) had a positive reaction to HEMA. The prevalence in women was 3.9%, in men 1.0%. Forty‐three (49%) reactions were judged to be of current clinical relevance and 21 (24%) of past relevance. In this group of 64 patients with relevant reactions, 18 (28%) had occupational contact with (meth)acrylate‐containing products, of who 11 (61%) were nail stylists. In 46 patients with non‐occupational allergic contact dermatitis, 31 (67%) had allergic reactions to nail cosmetics. Glues and glue‐containing products accounted for 22% of the materials causing allergic contact dermatitis and dental products for 8%. Conclusions: Allergic reactions to HEMA are very frequent in women investigated in Amsterdam. Nearly two thirds of cases were caused by nail cosmetics. [ABSTRACT FROM AUTHOR]

Background: Over the last 10 years, allergic contact dermatitis (ACD) from acrylate‐containing nail cosmetics (acrylic nails, gel nails, gel nail polish) has been reported repeatedly. Objectives: To investigate the frequency and clinical features of ACD in nail cosmetics in a university hospital in Amsterdam, The Netherlands. Patients and Methods: A retrospective study in patients diagnosed with ACD from acrylate‐containing nail cosmetics at the Amsterdam University Medical Centers between January 2015 and August 2023. Results: Sixty‐seven patients, all women, were diagnosed with ACD from nail cosmetics, representing 1.6% of all individuals and 2.3% of all women patch tested in this period. Sixty‐five of sixty‐seven (97%) subjects had a positive patch test to 2‐hydroxyethyl methacrylate (HEMA). Forty‐nine patients (73%) were consumers and 18 (27%) were professional nail stylists. The sites most frequently affected with dermatitis were the fingers (79%), hands (40%) and the head and/or neck. Avoidance of contact with acrylate‐containing products resulted in complete clearing of dermatitis in 80% of patients. Conclusions: ACD from acrylate‐containing nail cosmetics is frequent in women patch tested in Amsterdam. Nearly all were identified by a positive patch test to 2‐hydroxyethyl methacrylate in the (meth)acrylate series or the European baseline series. [ABSTRACT FROM AUTHOR]