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2. Safety assessment of food-contact paper and board using a battery of short-term toxicity tests: European union BIOSAFEPAPER project

Author

I. Severin, L. Dahbi, J. -C. Lhuguenot, M. A. Andersson, D. Hoornstra, M. Salkinoja-Salonen, L. Turco, F. Zucco, A. Stammati, O. Dahlman, L. Castle, M. Savolainen, A. Weber, U. Honkalampi-Hamalainen, A. Von Wright, Physiologie de la Nutrition et Toxicologie (NUTox) (U866, Lipides et nutrition, équipe 7) (NUTox), Lipides - Nutrition - Cancer (U866) (LNC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Department of Applied Chemistry and Microbiology [Helsinki], University of Helsinki, Department of Environmental and Primary Prevention, Istituto Superiore di Sanita [Rome], Istituto di Neurobiologia e Medicina Molecolare, Consiglio Nazionale delle Ricerche [Roma] (CNR), STFI-Packforsk AB, KCL Science and Consulting, and University of Kuopio, Institute of Applied Biotechnology

Subjects
Standardization, Health, Toxicology and Mutagenesis, Toxicology, Mice, 0302 clinical medicine, Environmental protection, Short term toxicity, Cells, Cultured, media_common, Mammals, 0303 health sciences, Food Packaging, Risk analysis (engineering), extraction procedures, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Safety, Paper, Battery (electricity), Cells, Food Contamination, [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain, Models, Biological, Risk Assessment, Gas Chromatography-Mass Spectrometry, 03 medical and health sciences, Cell Line, Tumor, Toxicity Tests, Animals, Humans, media_common.cataloged_instance, Dimethyl Sulfoxide, paper and board, European Union, European union, 030304 developmental biology, Ethanol, Food contact, Mutagenicity Tests, business.industry, Public Health, Environmental and Occupational Health, Product testing, Water, Environmental Exposure, General Chemistry, Consumer protection, Food safety, Cytotoxicity assays, Business, Food Analysis, Food Science
Abstract

International audience; An European Union (EU)-funded project QLK1-CT-2001-00930 (BIOSAFEPAPER) involves the development, validation and intercalibration of a short-term battery of toxicological tests for the safety assessment of food-contact paper and board. Dissemination of the results to industry, legislators (e.g. DG Consumer Protection, DG Enterprises, DG Research), standardization bodies such as CEN, and consumers will create an agreed risk evaluation procedure. The project involves pre-normative research in order to establish a set of in-vitro cytotoxicity and genotoxicity tests that will be easily adaptable to food-contact fibre-based materials and have endpoints relevant to consumer safety, including sub-lethal cellular events. These tests will be performed on samples representing actual migration conditions from food-contact paper and board with respect to different foodstuffs, and should form an experimental basis for scientifically sound recommendations for a harmonized system of risk evaluation and product testing.

Published
2005
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