1. Sjögren's syndrome and other rare and complex connective tissue diseases: an intriguing liaison.
- Author
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Baldini C, Arnaud L, Avčin T, Beretta L, Bellocchi C, Bouillot C, Burmester GR, Cavagna L, Cutolo M, de Vries-Bouwstra JK, Doria A, Ferro F, Fonseca JE, Fonzetti S, Fulvio G, Galetti I, Gottenberg JE, Hachulla E, Krieg T, La Rocca G, Martin T, Matucci-Cerinic M, Moinzadeh P, Montecucco C, Mosca M, Mouthon L, Müller-Ladner U, Rednic S, Smith V, Talarico R, van Laar JM, Vieira A, Romão VC, and Mariette X
- Subjects
- Humans, Autoimmune Diseases, Connective Tissue Diseases diagnosis, Connective Tissue Diseases genetics, Connective Tissue Diseases therapy, Lupus Erythematosus, Systemic diagnosis, Lupus Erythematosus, Systemic genetics, Lupus Erythematosus, Systemic therapy, Scleroderma, Systemic diagnosis, Scleroderma, Systemic genetics, Scleroderma, Systemic therapy, Sjogren's Syndrome diagnosis, Sjogren's Syndrome genetics, Sjogren's Syndrome therapy
- Abstract
Sjögren's syndrome (SS) is a systemic autoimmune disease that frequently occurs concomitantly with other systemic connective tissue disorders, including rare and complex diseases such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). The presence of SS influences the clinical expression of the other autoimmune diseases, thus offering the unique opportunity to explore the similarities in genetic signatures, as well as common environmental and biologic factors modulating the expression of disease phenotypes. In this review, we will specifically discuss the possibility of defining "SS/SLE" and "SS/SSc" as distinct subsets within the context of connective tissue diseases with different clinical expression and outcomes, thus deserving an individualised assessment and personalised medical interventions.
- Published
- 2022
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