1. Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
- Author
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Natàlia Romaní, Maria Pieras, Marie Antoinette Frick, Elena Sulleiro, Carlota Rodó, Aroa Silgado, Anna Suy, Maria Espiau, Claire Thorne, Carlo Giaquinto, Ana Felipe-Rucián, Pere Soler-Palacín, Antoni Soriano-Arandes, Institut Català de la Salut, [Romaní N, Pieras M, Frick MA, Espiau M, Soler-Palacín P, Soriano-Arandes A] Unitat de Patologia Infecciosa i Immunodeficiències de Pediatria, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sulleiro E, Silgado A] Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Barcelona, Spain. Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Rodó C, Suy A] Unitat de Medicina Fetal, Servei d’Obstetrícia i Medicina Reproductiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Felipe-Rucián A] Grup de Recerca en Neurologia Pediàtrica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Neurologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus
- Subjects
Sistema nerviós - Malalties ,infecciones bacterianas y micosis::infección::complicaciones infecciosas del embarazo [ENFERMEDADES] ,trastornos mentales::trastornos del desarrollo neurológico [PSIQUIATRÍA Y PSICOLOGÍA] ,virosis::infecciones por arbovirus::infección por el virus del Zika [ENFERMEDADES] ,personas::Grupos de Edad::lactante::recién nacido [DENOMINACIONES DE GRUPOS] ,Malalties transmissibles en l'embaràs ,Persons::Age Groups::Infant::Infant, Newborn [NAMED GROUPS] ,Arbovirosis ,Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores] ,Zika virus ,Zika virus infection ,arboviruses ,microcephaly ,congenital infection ,adverse outcome ,travel-associated ,children ,neonate ,mother-to-child transmission ,Pediatrics, Perinatology and Child Health ,Bacterial Infections and Mycoses::Infection::Pregnancy Complications, Infectious [DISEASES] ,Infants nadons ,Virus Diseases::Arbovirus Infections::Zika Virus Infection [DISEASES] ,Other subheadings::Other subheadings::/complications [Other subheadings] ,Mental Disorders::Neurodevelopmental Disorders [PSYCHIATRY AND PSYCHOLOGY] - Abstract
Zika virus infection; Microcephaly; Neonate Infección por el virus Zika; Microcefalia; Neonato Infecció pel virus Zika; Microcefàlia; Nounat Zika virus (ZIKV) is a vector-borne flavivirus with a known teratogenic effect, yet the full spectrum has not been delineated. Studies on endemic areas tried to characterize the clinical outcomes of ZIKV intrauterine exposure. We aimed to describe early neurodevelopmental outcomes on prenatally ZIKV-exposed children in a non-endemic ZIKV area. This is a prospective observational cohort study conducted from May 2016 to December 2021 at Hospital Universitari Vall d’Hebron in Barcelona, Catalonia, Spain. We monitored for up to 24 months 152 children extracted from a pregnant women cohort with suspected ZIKV infection; eleven women (11/150; 7.3%) fulfilled the criteria for a confirmed ZIKV infection. Among the 152 children included, we describe two cases of congenital ZIKV syndrome (CZS) born from women with a confirmed ZIKV infection. Additionally, we describe five cases of other potentially ZIKV-related outcomes (OPZROs), all with normal birth cranial circumference and born to women with probable ZIKV infection. The low exposed prevalence of adverse outcomes in asymptomatic children at birth in a non-endemic area suggests that close follow-up should be addressed by primary care pediatricians instead of pediatric specialists. Further studies are needed to assess the effects of ZIKV intrauterine exposure beyond two years of life. European Union’s Horizon 2020 research and innovation program under grant agreement No. 734857 (ZIKAction).
- Published
- 2022