1. The effect of vascular risk factor burden on the severity of COVID-19 illness, a retrospective cohort study
- Author
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Houwei Du, Xiaobin Pan, Nan Liu, Junnian Chen, Xiaoling Chen, David J. Werring, Gareth Ambler, Xiaoqing Li, Ronghua Chen, Yixian Zhang, Huayao Huang, Feifei Lin, Pincang Xia, Chao Chen, Zhenyang Zheng, Sangru Wu, Hanhan Lei, Lei Gao, Mingxu Huang, Kexu Lin, Xiaoping Xu, Yukun Luo, Ziwen Zhao, Chen Li, Hailong Lin, Yu Lin, Zhenghui Huang, Rongxiang Cao, Limin Chen, and On behalf of the Fujian Medical Team Support Wuhan for COVID-19
- Subjects
Male ,medicine.medical_specialty ,China ,Time Factors ,Population ,Pneumonia, Viral ,Disease ,Comorbidity ,030204 cardiovascular system & hematology ,Risk Assessment ,Severity of Illness Index ,Vascular risk factor ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Severity of illness ,Medicine ,Humans ,030212 general & internal medicine ,Vascular Diseases ,education ,Pandemics ,Aged ,Retrospective Studies ,lcsh:RC705-779 ,education.field_of_study ,Coronavirus disease 2019 ,business.industry ,Proportional hazards model ,SARS-CoV-2 ,Research ,Confounding ,COVID-19 ,Retrospective cohort study ,lcsh:Diseases of the respiratory system ,Middle Aged ,medicine.disease ,Prognosis ,Host-Pathogen Interactions ,Female ,business ,Risk assessment ,Coronavirus Infections - Abstract
Background Patients with cardiovascular comorbidities are at high risk of poor outcome from COVID-19. However, how the burden (number) of vascular risk factors influences the risk of severe COVID-19 disease remains unresolved. Our aim was to investigate the association of severe COVID-19 illness with vascular risk factor burden. Methods We included 164 (61.8 ± 13.6 years) patients with COVID-19 in this retrospective study. We compared the difference in clinical characteristics, laboratory findings and chest computed tomography (CT) findings between patients with severe and non-severe COVID-19 illness. We evaluated the association between the number of vascular risk factors and the development of severe COVID-19 disease, using a Cox regression model. Results Sixteen (9.8%) patients had no vascular risk factors; 38 (23.2%) had 1; 58 (35.4%) had 2; 34 (20.7%) had 3; and 18 (10.9%) had ≥4 risk factors. Twenty-nine patients (17.7%) experienced severe COVID-19 disease with a median (14 [7–27] days) duration between onset to developing severe COVID-19 disease, an event rate of 4.47 per 1000-patient days (95%CI 3.10–6.43). Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness (log-rank P Conclusions Patients with increasing vascular risk factor burden have an increasing risk of severe COVID-19 disease, and this population might benefit from specific COVID-19 prevention (e.g., self-isolation) and early hospital treatment measures.
- Published
- 2020