1. Frailty Among Breast Cancer Survivors: Evidence From Swedish Population Data.
- Author
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Wennberg, Alexandra M, Matthews, Anthony, Talbäck, Mats, Ebeling, Marcus, Ek, Stina, Feychting, Maria, and Modig, Karin
- Subjects
BREAST cancer prognosis ,FRAIL elderly ,CONFIDENCE intervals ,AGE distribution ,TIME ,CANCER patients ,RISK assessment ,COMPARATIVE studies ,DESCRIPTIVE statistics ,SURVIVAL analysis (Biometry) ,AGING ,AGE factors in disease ,RESEARCH funding ,LONGITUDINAL method - Abstract
Incidence and survival of breast cancer, the most common cancer among women, have been increasing, leaving survivors at risk of aging-related health conditions. In this matched cohort study, we examined frailty risk with the Hospital Frailty Risk Score among breast cancer survivors (n = 34,900) and age-matched comparison subjects (n = 290,063). Women born in 1935–1975, registered in the Swedish Total Population Register (1991–2015), were eligible for inclusion. Survivors had a first breast cancer diagnosis in 1991–2005 and survived ≥5 years after initial diagnosis. Death date was determined by linkage to the National Cause of Death Registry (through 2015). Cancer survivorship was weakly associated with frailty (subdistribution hazard ratio (SHR) = 1.04, 95% confidence interval (CI): 1.00, 1.07). In age-stratified models, those diagnosed at younger ages (<50 years) had higher risk of frailty (SHR = 1.12, 95% CI: 1.00, 1.24) than those diagnosed at ages 50–65 (SHR = 1.03, 95% CI: 0.98, 1.07) or >65 (SHR = 1.09, 95% CI: 1.02, 1.17) years. Additionally, there was increased risk of frailty for diagnoses in 2000 or later (SHR = 1.15, 95% CI: 1.09, 1.21) compared with before 2000 (SHR = 0.97, 95% CI: 0.93, 1.17). This supports work from smaller samples showing that breast cancer survivors have increased frailty risk, particularly when diagnosed at younger ages. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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