Purpose The purpose of this paper is to present a definition of modern configuration for a medium-altitude long-endurance unmanned aerial vehicle (MALE UAV) and its on-board systems to obtain a suitable basis for future definitions such as a possible logistic support configuration first hypothesis.Design/methodology/approach Starting from high-level requirements, both the UAV conceptual design and on-board systems preliminary design have been carried out through proprietary tools. Then, some peculiarities from previous studies, such as systems advanced UAV alternative energy, have been maintained and confirmed (diesel propulsion and energy storage system).Findings The improvement of a component of an aircraft can play a relevant role in the whole system. In the paper, it is considered how a concept of MALE UAV can evolve (this topic is considered by the authors since many years) by incorporating advanced on-board systems concepts.Practical implications The numerical results promote and support the use of advanced on-board system solutions and architectures to improve the effectiveness, efficiency and performance of MALE UAVs.Originality/value Usually, conceptual and preliminary design phases analyze in-depth the aerodynamic and structural solutions and aircraft performance. In this study, the authors aim to focus on the advanced on-board systems for MALE UAVs. This kind of aircraft is not yet a mature concept, with very few operating machines and many projects in the development phase. [ABSTRACT FROM AUTHOR]