1. Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
- Author
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Robert, Benjamin J.A., Moreau, Maïté, dos Santos Carvalho, Steve, Barthet, Gael, Racca, Claudia, Bhouri, Mehdi, Quiedeville, Anne, Garret, Maurice, Atchama, Bénédicte, Al Abed, Alice Shaam, Guette, Christelle, Henderson, Deborah, Desmedt, Aline, Mulle, Christophe, Marighetto, Aline, Montcouquiol, Mireille, Sans, Nathalie, CNRS, INCIA, 33000 Bordeaux, France, Université Bordeaux, INCIA, 33000 Bordeaux, France., Physiopathologie de la Plasticité Neuronale (Neurocentre Magendie - U1215 Inserm), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Interdisciplinary Institute for Neuroscience [Bordeaux] (IINS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Newcastle University [Newcastle], Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), and Garret, Maurice
- Subjects
hippocampus ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,[SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,computational function ,memory ,plasticity ,polarity ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,JNK ,granular cells ,AMPA receptors ,noncanonical Wnt-PCP signaling ,cognitive processes ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience; The organization of spatial information, including pattern completion and pattern separation processes, relies on the hippocampal circuits, yet the molecular and cellular mechanisms underlying these two processes are elusive. Here, we find that loss of Vangl2, a core PCP gene, results in opposite effects on pattern completion and pattern separation processes. Mechanistically, we show that Vangl2loss maintains young postmitotic granule cells in an immature state, providing increased cellular input for pattern separation. The genetic ablation of Vangl2disrupts granule cell morpho-functional maturation and further prevents CaMKII and GluA1 phosphorylation, disrupting the stabilization of AMPA receptors. As a functional consequence, LTP at lateral perforant path-GC synapses is impaired, leading to defects in pattern completion behavior. In conclusion, we show that Vangl2 exerts a bimodal regulation on young and mature GCs, and its disruption leads to an imbalance in hippocampus-dependent pattern completion and separation processes.
- Published
- 2020