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9 results on '"Moreau, François"'

1. PCSK9 is not secreted from mature differentiated intestinal cells

Author

Melissa Touvron, Cédric Le May, Thibaud Sotin, Xavier Prieur, L. Arnaud, Annik Prat, Anna Roubtsova, Claire Blanchard, Nabil G. Seidah, Wieneke Dijk, Audrey Ayer, Moreau François, Bertrand Cariou, Laurianne Van Landeghem, Gilliane Chadeuf, Damien Garçon, Aurélie Thedrez, Mikaël Croyal, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université de Montréal (UdeM), Centre hospitalier universitaire de Nantes (CHU Nantes), North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC), Dijk, Wieneke, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Cliniques de Montréal (IRCM), and Le May, Cedric

Subjects
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV]Life Sciences [q-bio], 3′DGE, 3′ digital gene expression, Regulator, 030204 cardiovascular system & hematology, Biochemistry, Caco-2 cell, PCSK9, Mice, 0302 clinical medicine, Endocrinology, Intestine, Small, liver-specific knockout, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, portal blood, Mice, Knockout, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, lipoprotein metabolism, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Chemistry, Cell Differentiation, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Cell biology, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, WB, Western blot, Kexin, Proprotein Convertase 9, Corrigendum, Research Article, DEGs, differentially expressed genes, Mice, Transgenic, QD415-436, Ussing chambers, endoH, endoglycosidase H, TICE, trans-intestinal cholesterol excretion, 03 medical and health sciences, Western blot, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Humans, Secretion, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, PCSK9 LivKO, mouse model lacking PCSK9 specifically in hepatocytes, intestine, 030304 developmental biology, PPL, postprandial lipemia, systemic blood, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Cell Biology, Proprotein convertase, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Small intestine, Mice, Inbred C57BL, LDL receptor, cholesterol metabolism, Caco-2 Cells, PCSK9, proprotein convertase subtilisin/kexin type 9, PNGase F, N-glycosidase F, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes lysosomal degradation of the LDL receptor and is a key regulator of cholesterol metabolism. After the liver, the small intestine is the second organ that highly expresses PCSK9. However, the small intestine's ability to secrete PCSK9 remains a matter of debate. While liver-specific PCSK9-deficient mice present no PCSK9 in systemic blood, human intestinal Caco-2 cells can actively secrete PCSK9. This raises the possibility for active intestinal secretion via the portal blood. Here, we aimed to determine whether enterocytes can secrete PCSK9 using in vitro, ex vivo, and in vivo approaches. We first observed that PCSK9 secretion from Caco-2 cells was biphasic and dependent on Caco-2 maturation status. Transcriptional analysis suggested that this transient reduction in PCSK9 secretion might be due to loss of SREBP2-mediated transcription of PCSK9. Consistently, PCSK9 secretion was not detected ex vivo in human or mouse intestinal biopsies mounted in Ussing chambers. Finally, direct comparison of systemic versus portal blood PCSK9 concentrations in WT or liver-specific PCSK9-deficient mice confirmed the inability of the small intestine to secrete PCSK9 into the portal compartment. Altogether, our data demonstrate that mature enterocytes do not secrete PCSK9 and reinforce the central role of the liver in the regulation of the concentration of circulating PCSK9 and consequently of cellular LDL receptors.

Published
2021

2. Digital Platforms and Cultural Industries

Author

Bouquillion, Philippe, Moreau, François, Centre d'Economie de l'Université Paris Nord (CEPN), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), Peter Lang, and MOREAU, François

Subjects
[SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2018

3. Les musiciens et la transformation numérique: Un nouvel équilibre ?

Author

MOREAU, François, Bacache-Beauvallet, Maya, Bourreau, Marc, MOREAU, François, Peter Lang, Centre d'Economie de l'Université Paris Nord (CEPN), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), Télécom ParisTech, and Département Sciences Economiques et Sociales (SES)

Subjects
[SHS] Humanities and Social Sciences, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2018

4. Digital consumption: A threat for local content?

Author

Lumeau, Marianne, MOREAU, François, Groupe de Recherche Angevin en Economie et Management (GRANEM), Université d'Angers (UA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de l'Horticulture et du Paysage, Centre d'Economie de l'Université Paris Nord (CEPN), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13), and Université d'Angers (UA)-AGROCAMPUS OUEST-Institut National de l'Horticulture et du Paysage

Subjects
[SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

5. Recent or Free: An experimental study of the motivations for pirating movies

Author

Lumeau, Marianne, Bourreau, Marc, MOREAU, François, Viotto Da Cruz, Jordana, Groupe de Recherche Angevin en Economie et Management (GRANEM), Université d'Angers (UA)-AGROCAMPUS OUEST-Institut National de l'Horticulture et du Paysage, Département Sciences Economiques et Sociales (SES), Télécom ParisTech, Economie Gestion (ECOGE), Institut interdisciplinaire de l’innovation (I3, une unité mixte de recherche CNRS (UMR 9217)), École polytechnique (X)-Télécom ParisTech-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Télécom ParisTech-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre d'Economie de l'Université Paris Nord (CEPN), Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13), Université d'Angers (UA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de l'Horticulture et du Paysage, Institut National de l'Horticulture et du Paysage-AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université d'Angers (UA)

Subjects
050208 finance, experiment, 05 social sciences, movies, ComputingMilieux_LEGALASPECTSOFCOMPUTING, [SHS]Humanities and Social Sciences, piracy, digitization, 0502 economics and business, ddc:330, free, 050207 economics, release windows, ComputingMilieux_MISCELLANEOUS
Abstract

The emergence of online providers aggregating illegal content from streaming platforms is rekindling the debate about online piracy. In the past, the discussion mainly focused on the impact of piracy in content industries and the effect of anti-piracy measures. But little is known about one crucial aspect of piracy: consumers' motivations to use illegal channels. Yet, understanding consumers' behavior could help practitioners and policymakers to allocate their resources better to fight online piracy. In this paper, we fill this gap by focusing on two main motives for the illegal consumption of online content: paying lower (zero) prices and having access to content that is not available in legal channels. To disentangle the role of each motivation in consumers' choice, we ran a laboratory experiment with real consumption, a methodology that provides participants with incentives to reveal their true preferences about consumption while controlling for the choice environment and the consideration set. Our results suggest that consumers turn to illegal channels primarily to save on the price of content, and that they are less sensitive to the availability of content in legal and illegal channels. We discuss the implications of our findings for practitioners and policymakers.

Published
2018

6. Financement participatif : une voie d'avenir pour la culture ?

Author

MOREAU, François, Nicolas, Yann, Centre d'Economie de l'Université Paris Nord (CEPN), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS), and Presses de Science Po

Subjects
ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2018

7. Ex vivo Mueller polarimetric imaging of the uterine cervix: a first statistical evaluation

Author

Rehbinder, Jean, Haddad, Huda, Deby, Stanislas, Teig, Benjamin, Nazac, André, Novikova, Tatiana, Pierangelo, Angelo, Moreau, François, and Novikova, Tatiana

Subjects
[PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [PHYS.PHYS] Physics [physics]/Physics [physics], ComputingMilieux_MISCELLANEOUS, [PHYS] Physics [physics]
Published
2016

8. L’excrétion trans -intestinale de cholestérol (TICE)

Author

Blanchard, Claire, MOREAU, François, Cariou, Bertrand, Le May, Cedric, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

9. L’artiste maudit 2.0 : l’impact des TIC sur le revenu des musiciens

Author

Maya Bacache-Beauvallet, François Moreau, Marc Bourreau, Télécom ParisTech, Département Sciences Economiques et Sociales (SES), Economie Gestion (ECOGE), Institut interdisciplinaire de l’innovation (I3, une unité mixte de recherche CNRS (UMR 9217)), École polytechnique (X)-Télécom ParisTech-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Télécom ParisTech-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre d'Economie de l'Université Paris Nord (CEPN), Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Télécom ParisTech-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), MOREAU, François, and Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
050402 sociology, 05 social sciences, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [SHS]Humanities and Social Sciences, 0504 sociology, Political science, 0502 economics and business, ICTS, [SHS] Humanities and Social Sciences, 050207 economics, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, General Economics, Econometrics and Finance, Humanities, Studio, ComputingMilieux_MISCELLANEOUS
Abstract

EnglishWe test, on the one hand, whether information and communication technologies (ICTs) represent an investment that increases the average income of artists and, on the other hand, whether ICTs modify the distribution of these revenues. We use an original database from a survey of Associate Musicians of Adami. We retain two indicators of ICT investment: the use of a home studio and the presence of the artist on the Internet. We show that ICT investment increases average income and that income inequality increases with network effects on the Internet, but decreases with economies of scale allowed by new technologies. francaisNous testons, d’une part, si les technologies de l’information et de la communication (TIC) representent un investissement qui augmente le revenu moyen des artistes et, d’autre part, si les TIC modifient la distribution de ces revenus. Nous exploitons une base de donnees originale issue d’une enquete aupres des musiciens associes de l’Adami. Nous retenons deux indicateurs de l’investissement en TIC : l’utilisation d’un home studio et la presence de l’artiste sur Internet. Nous montrons que l’investissement en TIC augmente le revenu moyen et que les inegalites de revenus augmentent avec les effets de reseau sur Internet, mais diminuent avec les economies d’echelle permises par les nouvelles technologies.

Published
2018

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