1. Multi-spin-echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry
- Author
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Davis, Ryan M, Zhou, Zijian, Chung, Hyunkoo, and Warren, Warren S.
- Subjects
Models, Statistical ,Echo-Planar Imaging ,Phantoms, Imaging ,Temperature ,Contrast Media ,Reproducibility of Results ,Hyperthermia, Induced ,Signal-To-Noise Ratio ,Image Enhancement ,Magnetic Resonance Imaging ,Article ,Bone Marrow ,Image Interpretation, Computer-Assisted ,Anisotropy ,Humans ,Quantum Theory ,Computer Simulation ,Algorithms - Abstract
Intermolecular multiple quantum coherences (iMQCs) are a source of MR contrast with applications including temperature imaging, anisotropy mapping, and brown fat imaging. Because all applications are limited by signal-to-noise ratio (SNR), we developed a pulse sequence that detects intermolecular zero quantum coherences with improved SNR.A previously developed pulse sequence that detects iMQCs, HOMOGENIZED with off resonance transfer (HOT), was modified with a multi-spin echo spatial encoding scheme (MSE-HOT). MSE-HOT uses a series of refocusing pulses to generate a stack of images that are averaged in postprocessing for higher SNR. MSE-HOT performance was quantified by measuring its temperature accuracy and precision during hyperthermia of ex vivo red bone marrow samples.MSE-HOT yielded a three-fold improvement in temperature precision relative to previous pulse sequences. Sources of improved precision were 1) echo averaging and 2) suppression of J-coupling in the methylene protons of fat. MSE-HOT measured temperature change with an accuracy of 0.6°C.MSE-HOT improved the temperature accuracy and precision of HOT to a level that is sufficient for hyperthermia of bone marrow.
- Published
- 2015