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In this paper, we study the problem of adapting manipulation trajectories involving grasped objects (e.g. tools) defined for a single grasp pose to novel grasp poses. A common approach to address this is to define a new trajectory for each possible grasp explicitly, but this is highly inefficient. Instead, we propose a method to adapt such trajectories directly while only requiring a period of self-supervised data collection, during which a camera observes the robot's end-effector moving with the object rigidly grasped. Importantly, our method requires no prior knowledge of the grasped object (such as a 3D CAD model), it can work with RGB images, depth images, or both, and it requires no camera calibration. Through a series of real-world experiments involving 1360 evaluations, we find that self-supervised RGB data consistently outperforms alternatives that rely on depth images including several state-of-the-art pose estimation methods. Compared to the best-performing baseline, our method results in an average of 28.5% higher success rate when adapting manipulation trajectories to novel grasps on several everyday tasks. Videos of the experiments are available on our webpage at https://www.robot-learning.uk/adapting-skills, Comment: Accepted at IROS 2024

In this paper, we study imitation learning under the challenging setting of: (1) only a single demonstration, (2) no further data collection, and (3) no prior task or object knowledge. We show how, with these constraints, imitation learning can be formulated as a combination of trajectory transfer and unseen object pose estimation. To explore this idea, we provide an in-depth study on how state-of-the-art unseen object pose estimators perform for one-shot imitation learning on ten real-world tasks, and we take a deep dive into the effects that camera calibration, pose estimation error, and spatial generalisation have on task success rates. For videos, please visit https://www.robot-learning.uk/pose-estimation-perspective., Comment: Published at the 7th Conference on Robot Learning (CoRL 2023). For more details please visit https://www.robot-learning.uk/pose-estimation-perspective

This paper introduces a modular framework for Mixed-variable and Combinatorial Bayesian Optimization (MCBO) to address the lack of systematic benchmarking and standardized evaluation in the field. Current MCBO papers often introduce non-diverse or non-standard benchmarks to evaluate their methods, impeding the proper assessment of different MCBO primitives and their combinations. Additionally, papers introducing a solution for a single MCBO primitive often omit benchmarking against baselines that utilize the same methods for the remaining primitives. This omission is primarily due to the significant implementation overhead involved, resulting in a lack of controlled assessments and an inability to showcase the merits of a contribution effectively. To overcome these challenges, our proposed framework enables an effortless combination of Bayesian Optimization components, and provides a diverse set of synthetic and real-world benchmarking tasks. Leveraging this flexibility, we implement 47 novel MCBO algorithms and benchmark them against seven existing MCBO solvers and five standard black-box optimization algorithms on ten tasks, conducting over 4000 experiments. Our findings reveal a superior combination of MCBO primitives outperforming existing approaches and illustrate the significance of model fit and the use of a trust region. We make our MCBO library available under the MIT license at \url{https://github.com/huawei-noah/HEBO/tree/master/MCBO}.

Antibodies are canonically Y-shaped multimeric proteins capable of highly specific molecular recognition. The CDRH3 region located at the tip of variable chains of an antibody dominates antigen-binding specificity. Therefore, it is a priority to design optimal antigen-specific CDRH3 regions to develop therapeutic antibodies. However, the combinatorial nature of CDRH3 sequence space makes it impossible to search for an optimal binding sequence exhaustively and efficiently using computational approaches. Here, we present \texttt{AntBO}: a combinatorial Bayesian optimisation framework enabling efficient \textit{in silico} design of the CDRH3 region. Ideally, antibodies are expected to have high target specificity and developability. We introduce a CDRH3 trust region that restricts the search to sequences with favourable developability scores to achieve this goal. For benchmarking, \texttt{AntBO} uses the \texttt{Absolut!} software suite as a black-box oracle to score the target specificity and affinity of designed antibodies \textit{in silico} in an unconstrained fashion~\citep{robert2021one}. The experiments performed for $159$ discretised antigens used in \texttt{Absolut!} demonstrate the benefit of \texttt{AntBO} in designing CDRH3 regions with diverse biophysical properties. In under $200$ calls to black-box oracle, \texttt{AntBO} can suggest antibody sequences that outperform the best binding sequence drawn from 6.9 million experimentally obtained CDRH3s and a commonly used genetic algorithm baseline. Additionally, \texttt{AntBO} finds very-high affinity CDRH3 sequences in only 38 protein designs whilst requiring no domain knowledge. We conclude \texttt{AntBO} brings automated antibody design methods closer to what is practically viable for in vitro experimentation.

Eye-in-hand camera calibration is a fundamental and long-studied problem in robotics. We present a study on using learning-based methods for solving this problem online from a single RGB image, whilst training our models with entirely synthetic data. We study three main approaches: one direct regression model that directly predicts the extrinsic matrix from an image, one sparse correspondence model that regresses 2D keypoints and then uses PnP, and one dense correspondence model that uses regressed depth and segmentation maps to enable ICP pose estimation. In our experiments, we benchmark these methods against each other and against well-established classical methods, to find the surprising result that direct regression outperforms other approaches, and we perform noise-sensitivity analysis to gain further insights into these results., Comment: Published at the 2021 Conference on Robot Learning (CoRL). Webpage and video: https://www.robot-learning.uk/learning-eye-in-hand-calibration