To realize the deep integration of complex product manufacturing and operation and maintenance processes, while eliminate the phenomenon of information islands generated in the manufacturing and operation and maintenance links, in the light of the lack of in-depth integration in the manufacturing and operation and maintenance process of complex products. With the help of digital twin technology, this paper puts forward the overall framework manufacturing and operation and maintenance integration of a complex product based on digital twin and the system integration mode of virtual and real integration. The solutions of complex product integration of manufacturing and operations and maintenance, data fusion, modeling and simulation, and manufacturing plant operation mode based on digital twin are analyzed. The key technologies based on digital twin deep integration of manufacturing and operation and maintenance, fault prediction, and knowledge base/case library construction are discussed. Finally, combined with the fault prediction case of a certain type of electric multiple units (EMU) bogie, the associated operation mode between the operation and maintenance process of the EMU and the manufacturer is demonstrated, which proves the feasibility and effectiveness of the integration method.