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Introduction/Background* In advanced stage high grade serous ovarian cancer (HGSOC), the introduction of maximal surgical effort without compromising peri-operative management and subsequent recovery to achieve complete cytoreduction, requires Critical Care Unit (CCU) availability. This paradigm shift prompts the development of tools to accurately predict CCU admission following cytoreductive surgery. Modern data mining technology, such as Machine Learning (ML) could be helpful in accurately predicting CCU admissions to improve standards of care. We developed a framework to improve the accuracy of predicting CCU admission in HGSOC patients by use of ML algorithms (figure 1). Methodology A cohort of 291 advanced stage HGSOC patients, who underwent surgical cytoreduction from Jan 2014 to Dec 2019, was selected from the ovarian database. They were randomly assigned to training (60%) and test (40%) sub-cohorts. Forward selection and backward stepwise regression were employed to screen independent pre- and intra-operative variables. Linear (LDA), Quadratic (QDA), and non-linear distance (ANN and KNN) ML models were employed to derive predictive information. These methods were tested against conventional linear regression (LR). Model performance was evaluated by prediction accuracy, sensitivity, specificity, and F1 scores. Result(s)* We identified 56/291(19.2%) CCU admissions. For the outcome of CCU admission, the prediction accuracies were higher for LDA (0.90) and QDA (0.93) compared with LR (0.84) when all the variables were included in the in-built model. Feature selection identified pre-treatment albumin, surgical complexity score, estimated blood loss, operative time, and bowel resection with stoma formation as the most significant prediction features. With feature selection, the prediction accuracies were higher for LDA (0.89) and KNN (0.86) compared with LR (0.82). Admission to CCU was associated with increased length of stay (P = 0.000), and decreased number of postoperative complications (P = 0.001). Conclusion* Herein, ML algorithms accurately predicted HGSOC patients, who required CCU admission following their cytoreductive surgery. Linear discriminant analysis was consistently more predictive than LR for CCU admission, irrespective of the number of features included in the analysis. Limited, potentially modifiable, mostly intra-operative factors contributing to CCU admission were identified and suggest areas for targeted interventions.