15 results on '"Nesterets, Yakov"'
Search Results
2. X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron.
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Arhatari, Benedicta D., Stevenson, Andrew W., Abbey, Brian, Nesterets, Yakov I., Maksimenko, Anton, Hall, Christopher J., Thompson, Darren, Mayo, Sheridan C., Fiala, Tom, Quiney, Harry M., Taba, Seyedamir T., Lewis, Sarah J., Brennan, Patrick C., Dimmock, Matthew, Häusermann, Daniel, and Gureyev, Timur E.
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COMPUTED tomography ,DIAGNOSTIC imaging ,X-ray imaging ,SYNCHROTRONS ,SYNCHROTRON radiation ,BREAST imaging - Abstract
The Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology Organisation (ANSTO). The beamline delivers hard X-rays in the 25–120 keV energy range and offers the potential for a range of biomedical X-ray applications, including radiotherapy and medical imaging experiments. One of the imaging modalities available at IMBL is propagation-based X-ray phase-contrast computed tomography (PCT). PCT produces superior results when imaging low-density materials such as soft tissue (e.g., breast mastectomies) and has the potential to be developed into a valuable medical imaging tool. We anticipate that PCT will be utilized for medical breast imaging in the near future with the advantage that it could provide better contrast than conventional X-ray absorption imaging. The unique properties of synchrotron X-ray sources such as high coherence, energy tunability, and high brightness are particularly well-suited for generating PCT data using very short exposure times on the order of less than 1 min. The coherence of synchrotron radiation allows for phase-contrast imaging with superior sensitivity to small differences in soft-tissue density. Here we also compare the results of PCT using two different detectors, as these unique source characteristics need to be complemented with a highly efficient detector. Moreover, the application of phase retrieval for PCT image reconstruction enables the use of noisier images, potentially significantly reducing the total dose received by patients during acquisition. This work is part of ongoing research into innovative tomographic methods aimed at the introduction of 3D X-ray medical imaging at the IMBL to improve the detection and diagnosis of breast cancer. Major progress in this area at the IMBL includes the characterization of a large number of mastectomy samples, both normal and cancerous, which have been scanned at clinically acceptable radiation dose levels and evaluated by expert radiologists with respect to both image quality and cancer diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
3. Comparison of propagation-based CT using synchrotron radiation and conventional cone-beam CT for breast imaging.
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Tavakoli Taba, Seyedamir, Baran, Patrycja, Nesterets, Yakov I., Pacile, Serena, Wienbeck, Susanne, Dullin, Christian, Pavlov, Konstantin, Maksimenko, Anton, Lockie, Darren, Mayo, Sheridan C., Quiney, Harry M., Dreossi, Diego, Arfelli, Fulvia, Tromba, Giuliana, Lewis, Sarah, Gureyev, Timur E., and Brennan, Patrick C.
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SYNCHROTRON radiation ,CONE beam computed tomography ,BREAST imaging ,INTRACLASS correlation ,COMPUTED tomography - Abstract
Objectives: To evaluate and compare the image quality of propagation-based phase-contrast computed tomography (PB-CT) using synchrotron radiation and conventional cone-beam breast computed tomography (CBBCT) based on various radiological image quality criteria.Methods: Eight excised breast tissue samples of various sizes and containing different lesion types were scanned using PB-CT at a synchrotron facility and using CBBCT at a university-affiliated breast imaging centre. PB-CT scans were performed at two different mean glandular dose (MGD) levels: standard (5.8 mGy) and low (1.5 mGy), for comparison with CBBCT scans at the standard MGD (5.8 mGy). Image quality assessment was carried out using six quality criteria and six independent medical imaging experts in a reading room with mammography workstations. The interobserver agreement between readers was evaluated using intraclass correlation coefficient (ICC), and image quality was compared between the two breast imaging modalities using the area under the visual grading characteristic curve (AUCVGC).Results: Interobserver agreement between the readers showed moderate reliability for five image criteria (ICC: ranging from 0.488 to 0.633) and low reliability for one criterion (image noise) (ICC 0.307). For five image quality criteria (overall quality, perceptible contrast, lesion sharpness, normal tissue interfaces, and calcification visibility), both standard-dose PB-CT images (AUCVGC 0.958 to 1, p ≤ .05) and low dose PB-CT images (AUCVGC 0.785 to 0.834, p ≤ .05) were of significantly higher image quality than standard-dose CBBCT images.Conclusions: Synchrotron-based PB-CT can achieve a significantly higher radiological image quality at a substantially lower radiation dose compared with conventional CBBCT.Key Points: • PB-CT using synchrotron radiation results in higher image quality than conventional CBBCT for breast imaging. • PB-CT using synchrotron radiation requires a lower radiation dose than conventional CBBCT for breast imaging. • PB-CT can help clinicians diagnose patients with breast cancer. [ABSTRACT FROM AUTHOR]- Published
- 2020
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- View/download PDF
4. Toward Improving Breast Cancer Imaging: Radiological Assessment of Propagation-Based Phase-Contrast CT Technology.
- Author
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Tavakoli Taba, Seyedamir, Baran, Patrycja, Lewis, Sarah, Heard, Robert, Pacile, Serena, Nesterets, Yakov I., Mayo, Sherry C., Dullin, Christian, Dreossi, Diego, Arfelli, Fulvia, Thompson, Darren, McCormack, Mikkaela, Alakhras, Maram, Brun, Francesco, Pinamonti, Maurizio, Nickson, Carolyn, Hall, Chris, Zanconati, Fabrizio, Lockie, Darren, and Quiney, Harry M
- Abstract
Rationale and Objectives: This study employs clinical/radiological evaluation in establishing the optimum imaging conditions for breast cancer imaging using the X-ray propagation-based phase-contrast tomography.Materials and Methods: Two series of experiments were conducted and in total 161 synchrotron-based computed tomography (CT) reconstructions of one breast mastectomy specimen were produced at different imaging conditions. Imaging factors include sample-to-detector distance, X-ray energy, CT reconstruction method, phase retrieval algorithm applied to the CT projection images and maximum intensity projection. Observers including breast radiologists and medical imaging experts compared the quality of the reconstructed images with reference images approximating the conventional (absorption) CT. Various radiological image quality attributes in a visual grading analysis design were used for the radiological assessments.Results: The results show that the application of the longest achievable sample-to-detector distance (9.31 m), the lowest employed X-ray energy (32 keV), the full phase retrieval, and the maximum intensity projection can significantly improve the radiological quality of the image. Several combinations of imaging variables resulted in images with very high-quality scores.Conclusion: The results of the present study will support future experimental and clinical attempts to further optimize this innovative approach to breast cancer imaging. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
5. Fast three‐dimensional phase retrieval in propagation‐based X‐ray tomography.
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Thompson, Darren A., Nesterets, Yakov I., Pavlov, Konstantin M., and Gureyev, Timur E.
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TOMOGRAPHY , *TRANSPORT theory , *X-rays , *X-ray imaging , *PHASE-shifting interferometry , *COMPUTER simulation - Abstract
The following article describes a method for 3D reconstruction of multi‐material objects based on propagation‐based X‐ray phase‐contrast tomography (PB‐CT) with phase retrieval using the homogeneous form of the transport of intensity equation (TIE‐Hom). Unlike conventional PB‐CT algorithms that perform phase retrieval of individual projections, the described post‐reconstruction phase‐retrieval method is applied in 3D to a localized region of the CT‐reconstructed volume. This work demonstrates, via numerical simulations, the accuracy and noise characteristics of the method under a variety of experimental conditions, comparing it with both conventional absorption tomography and 2D TIE‐Hom phase retrieval applied to projection images. The results indicate that the 3D post‐reconstruction method generally achieves a modest improvement in noise suppression over existing PB‐CT methods. It is also shown that potentially large computational gains over projection‐based phase retrieval for multi‐material samples are possible. In particular, constraining phase retrieval to a localized 3D region of interest reduces the overall computational cost and eliminates the need for multiple CT reconstructions and global 2D phase retrieval operations for each material within the sample. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
6. High-Resolution X-Ray Phase-Contrast 3-D Imaging of Breast Tissue Specimens as a Possible Adjunct to Histopathology.
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Baran, Patrycja, Mayo, Sheridan, McCormack, Mikkaela, Pacile, Serena, Tromba, Giuliana, Dullin, Christian, Zanconati, Fabrizio, Arfelli, Fulvia, Dreossi, Diego, Fox, Jane, Prodanovic, Zdenka, Cholewa, Marian, Quiney, Harry, Dimmock, Matthew, Nesterets, Yakov, Thompson, Darren, Brennan, Patrick, and Gureyev, Timur
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THREE-dimensional imaging ,HISTOPATHOLOGY ,BREAST cancer diagnosis ,COMPUTED tomography ,COMPARATIVE studies - Abstract
Histopathological analysis is the current gold standard in breast cancer diagnosis and management, however, as imaging technology improves, the amount of potential diagnostic information that may be demonstrable radiologically should also increase. We aimed to evaluate the potential clinical usefulness of 3-D phase-contrast micro-computed tomography (micro-CT) imaging at high spatial resolutions as an adjunct to conventional histological microscopy. Ten breast tissue specimens, 2 mm in diameter, were scanned at the SYRMEP beamline of the Elettra Synchrotron using the propagation-based phase-contrast micro-tomography method. We obtained $1.2~\mu \text{m}$ pixel size images, which were analyzed and compared with corresponding histological sections examined under light microscopy. To evaluate the effect of spatial resolution on breast cancer diagnosis, scans with four different pixel sizes were also performed. Our comparative analysis revealed that high-resolution images can enable, at a near-histological level, detailed architectural assessment of tissue that may permit increased breast cancer diagnostic sensitivity and specificity when compared with current imaging practices. The potential clinical applications of this method are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
7. Advantages of breast cancer visualization and characterization using synchrotron radiation phase‐contrast tomography.
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Pacilè, Serena, Baran, Patrycja, Dullin, Christian, Dimmock, Matthew, Lockie, Darren, Missbach-Guntner, Jeannine, Quiney, Harry, McCormack, Mikkaela, Mayo, Sheridan, Thompson, Darren, Nesterets, Yakov, Hall, Chris, Pavlov, Konstantin, Prodanovic, Zdenka, Tonutti, Maura, Accardo, Agostino, Fox, Jane, Tavakoli Taba, Seyedamir, Lewis, Sarah, and Brennan, Patrick
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BREAST cancer diagnosis ,COMPUTED tomography ,SYNCHROTRON radiation ,TOMOSYNTHESIS ,MASTECTOMY ,IMAGE reconstruction - Abstract
The aim of this study was to highlight the advantages that propagation‐based phase‐contrast computed tomography (PB‐CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB‐CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB‐CT volume rather than conventional two‐dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB‐CT images is significantly higher than one using conventional techniques. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
8. A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron.
- Author
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Nesterets, Yakov I., Gureyev, Timur E., Mayo, Sheridan C., Stevenson, Andrew W., Thompson, Darren, Brown, Jeremy M. C., Kitchen, Marcus J., Pavlov, Konstantin M., Lockie, Darren, Brun, Francesco, and Tromba, Giuliana
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SYNCHROTRONS , *PHASE contrast magnetic resonance imaging , *COMPLEMENTARY metal oxide semiconductors - Abstract
Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low-dose high-sensitivity three-dimensional mammographic phase-contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X-ray energy, source size, detector resolution, sample-to-detector distance, scanning and data processing strategies in the case of propagation-based phase-contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast-tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 µm, revealed the presence of propagation-based phase contrast and demonstrated significant improvement of the quality of phase-contrast CT imaging compared with conventional (absorption-based) CT, at medically acceptable radiation doses. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
9. Noise propagation in x-ray phase-contrast imaging and computed tomography.
- Author
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Nesterets, Yakov I and Gureyev, Timur E
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NOISE barriers , *X-ray imaging , *COMPUTED tomography , *GEOMETRICAL optics , *SIGNAL-to-noise ratio , *ANALYSIS of variance - Abstract
Three phase-retrieval algorithms, based on the transport-of-intensity equation and on the contrast transfer function for propagation-based imaging, and on the linearized geometrical optics approximation for analyser-based imaging, are investigated. The algorithms are compared in terms of their effect on propagation of noise from projection images to the corresponding phase-retrieved images and further to the computed tomography (CT) images/slices of a monomorphous object reconstructed using filtered backprojection algorithm. The comparison is carried out in terms of an integral noise characteristic, the variance, as well as in terms of a simple figure-of-merit, i.e. signal-to-noise ratio per unit dose. A gain factor is introduced that quantitatively characterizes the effect of phase retrieval on the variance of noise in the reconstructed projection images and in the axial slices of the object. Simple analytical expressions are derived for the gain factor and the signal-to-noise ratio, which indicate that the application of phase-retrieval algorithms can increase these parameters by up to two orders of magnitude compared to raw projection images and conventional CT, thus allowing significant improvement in the image quality and/or reduction of the x-ray dose delivered to the patient. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
10. Quantitative micro-porosity characterization using synchrotron micro-CT and xenon K-edge subtraction in sandstones, carbonates, shales and coal.
- Author
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Mayo, Sheridan, Josh, Matthew, Nesterets, Yakov, Esteban, Lionel, Pervukhina, Marina, Clennell, Michael Ben, Maksimenko, Anton, and Hall, Chris
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POROSITY , *SYNCHROTRON radiation , *COMPUTED tomography , *XENON , *SANDSTONE , *CARBONATES , *COAL - Abstract
Understanding porosity in rock specimens on a range of length scales is critical for assessment of geophysical properties relevant to petroleum and geothermal resources. Modern micro-CT techniques can show detail down to around a micron scale but cannot unambiguously detect porosity below the resolution limit. Here we describe the use of synchrotron K-edge subtraction using a xenon gas contrast agent to probe porosity on the micron scale in a range of rock types. Xenon, which has also been used in larger-scale studies, is an attractive contrast agent for investigating very small-scale porosity in non-sorbing specimens, and gas uptake in sorbing specimens. The K-edge subtraction method enables accurate separation of the rock and xenon signal so that xenon penetration and hence porosity can be quantitatively determined even where the individual pores themselves cannot be directly resolved. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
11. High-Resolution X-Ray Phase-Contrast 3-D Imaging of Breast Tissue Specimens as a Possible Adjunct to Histopathology
- Author
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Christian Dullin, Sheridan C Mayo, Marian Cholewa, Fulvia Arfelli, Timur E. Gureyev, Harry M. Quiney, Diego Dreossi, Zdenka Prodanovic, Matthew Richard Dimmock, Fabrizio Zanconati, Patrycja Baran, Patrick C. Brennan, Yakov Nesterets, Mikkaela McCormack, Serena Pacilè, Darren Thompson, Giuliana Tromba, Jane Fox, Baran, Patrycja, Mayo, Sheridan, Mccormack, Mikkaela, Pacile, Serena, Tromba, Giuliana, Dullin, Christian, Zanconati, Fabrizio, Arfelli, Fulvia, Dreossi, Diego, Fox, Jane, Prodanovic, Zdenka, Cholewa, Marian, Quiney, Harry, Dimmock, Matthew, Nesterets, Yakov, Thompson, Darren, Brennan, Patrick, and Gureyev, Timur
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medicine.medical_specialty ,Materials science ,Breast Neoplasms ,phase contrast ,Electronic mail ,030218 nuclear medicine & medical imaging ,histology ,03 medical and health sciences ,Imaging, Three-Dimensional ,breast cancer ,0302 clinical medicine ,Breast cancer ,Microscopy ,medicine ,Humans ,Breast ,Electrical and Electronic Engineering ,Computed tomography ,X-ray imaging ,Software ,Radiological and Ultrasound Technology ,Computer Science Applications1707 Computer Vision and Pattern Recognition ,Image resolution ,Aged, 80 and over ,business.industry ,X-Ray Microtomography ,Gold standard (test) ,Middle Aged ,medicine.disease ,Computer Science Applications ,030220 oncology & carcinogenesis ,Imaging technology ,Female ,Histopathology ,Tomography ,Nuclear medicine ,business ,Algorithms - Abstract
Histopathological analysis is the current gold standard in breast cancer diagnosis and management, however, as imaging technology improves, the amount of potential diagnostic information that may be demonstrable radiologically should also increase. We aimed to evaluate the potential clinical usefulness of 3-D phase-contrast micro-computed tomography (micro-CT) imaging at high spatial resolutions as an adjunct to conventional histological microscopy. Ten breast tissue specimens, 2 mm in diameter, were scanned at the SYRMEP beamline of the Elettra Synchrotron using the propagation-based phase-contrast micro-tomography method. We obtained $1.2~\mu \text{m}$ pixel size images, which were analyzed and compared with corresponding histological sections examined under light microscopy. To evaluate the effect of spatial resolution on breast cancer diagnosis, scans with four different pixel sizes were also performed. Our comparative analysis revealed that high-resolution images can enable, at a near-histological level, detailed architectural assessment of tissue that may permit increased breast cancer diagnostic sensitivity and specificity when compared with current imaging practices. The potential clinical applications of this method are also discussed.
- Published
- 2018
12. Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging
- Author
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Patrycja Baran, Seyedamir Tavakoli Taba, Patrick C. Brennan, Chris Hall, Fabrizio Zanconati, Giuliana Tromba, Diego Dreossi, Tim E. Gureyev, Sheridan C Mayo, Francesco Brun, Matthew Richard Dimmock, Darren Lockie, Darren Thompson, Mikkaela McCormack, Marian Cholewa, Maurizio Pinamonti, Fulvia Arfelli, Harry M. Quiney, Yakov Nesterets, Carolyn Nickson, Christian Dullin, Serena Pacilè, Baran, Patrycja, Pacilè, Serena, Nesterets, Yakov, Mayo, Sheridan, Dullin, Christian, Dreossi, Diego, Arfelli, Fulvia, Thompson, Darren, Lockie, Darren, Mccormack, Mikkaela, Taba, Seyedamir, Brun, Francesco, Pinamonti, Maurizio, Nickson, Carolyn, Hall, Christopher, Dimmock, Matthew, Zanconati, Fabrizio, Cholewa, Marian, Quiney, Harry, Brennan, Patrick, Tromba, Giuliana, and Gureyev, Tim E.
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Digital mammography ,Image quality ,Computer science ,mammography ,Phase contrast microscopy ,Breast Neoplasms ,Computed tomography ,Radiation ,030218 nuclear medicine & medical imaging ,law.invention ,RC0254 ,03 medical and health sciences ,Computed Tomography ,breast cancer ,0302 clinical medicine ,Breast cancer ,law ,medicine ,Humans ,Mammography ,Radiology, Nuclear Medicine and imaging ,X-ray imaging ,X-ray phase contrast ,Computed tomography laser mammography ,Radiological and Ultrasound Technology ,medicine.diagnostic_test ,Tomography, X-Ray ,X-Rays ,X-ray ,Benign lesion ,medicine.disease ,Tomosynthesis ,Beamline ,030220 oncology & carcinogenesis ,Female ,Tomography ,Phase retrieval ,RA ,Human breast ,Biomedical engineering - Abstract
The aim of this study was to optimise the experimental protocol and data analysis for in-vivo breast cancer x-ray imaging. Results are presented of the experiment at the SYRMEP beamline of Elettra Synchrotron using the propagation-based phase-contrast mammographic tomography method, which incorporates not only absorption, but also x-ray phase information. In this study the images of breast tissue samples, of a size corresponding to a full human breast, with radiologically acceptable x-ray doses were obtained, and the degree of improvement of the image quality (from the diagnostic point of view) achievable using propagation-based phase-contrast image acquisition protocols with proper incorporation of x-ray phase retrieval into the reconstruction pipeline was investigated. Parameters such as the x-ray energy, sample-to-detector distance and data processing methods were tested, evaluated and optimized with respect to the estimated diagnostic value using a mastectomy sample with a malignant lesion. The results of quantitative evaluation of images were obtained by means of radiological assessment carried out by 13 experienced specialists. A comparative analysis was performed between the x-ray and the histological images of the specimen. The results of the analysis indicate that, within the investigated range of parameters, both the objective image quality characteristics and the subjective radiological scores of propagation-based phase-contrast images of breast tissues monotonically increase with the strength of phase contrast which in turn is directly proportional to the product of the radiation wavelength and the sample-to-detector distance. The outcomes of this study serve to define the practical imaging conditions and the CT reconstruction procedures appropriate for low-dose phase-contrast mammographic imaging of live patients at specially designed synchrotron beamlines.
- Published
- 2017
13. Toward Improving Breast Cancer Imaging: Radiological Assessment of Propagation-Based Phase-Contrast CT Technology
- Author
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Timur E. Gureyev, Patrick C. Brennan, Chris Hall, Carolyn Nickson, Serena Pacilè, Robert Heard, Harry M. Quiney, Fabrizio Zanconati, Darren Thompson, Seyedamir Tavakoli Taba, Christian Dullin, Yakov Nesterets, Giuliana Tromba, Maram Alakhras, S. C. Mayo, Sarah J. Lewis, Fulvia Arfelli, Darren Lockie, Patrycja Baran, Diego Dreossi, Francesco Brun, Mikkaela McCormack, Maurizio Pinamonti, Tavakoli Taba, Seyedamir, Baran, Patrycja, Lewis, Sarah, Heard, Robert, Pacile, Serena, Nesterets, Yakov I., Mayo, Sherry C., Dullin, Christian, Dreossi, Diego, Arfelli, Fulvia, Thompson, Darren, Mccormack, Mikkaela, Alakhras, Maram, Brun, Francesco, Pinamonti, Maurizio, Nickson, Carolyn, Hall, Chri, Zanconati, Fabrizio, Lockie, Darren, Quiney, Harry M, Tromba, Giuliana, Gureyev, Timur E, and Brennan, Patrick C
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Radiology, Nuclear Medicine and Imaging ,Image quality ,Computer science ,Breast Neoplasms ,X-ray propagation-based imaging (PBI) ,Breast cancer ,Computed tomography ,Phase-contrast imaging ,Radiological assessment ,Nuclear Medicine and Imaging ,Image Interpretation, Computer-Assisted ,Medical imaging ,medicine ,Humans ,Mammography ,Radiology, Nuclear Medicine and imaging ,Breast ,Projection (set theory) ,Aged ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Maximum intensity projection ,Female ,Tomography ,Tomography, X-Ray Computed ,Nuclear medicine ,business ,Radiology ,Algorithms - Abstract
Rationale and Objectives This study employs clinical/radiological evaluation in establishing the optimum imaging conditions for breast cancer imaging using the X-ray propagation-based phase-contrast tomography. Materials and Methods Two series of experiments were conducted and in total 161 synchrotron-based computed tomography (CT) reconstructions of one breast mastectomy specimen were produced at different imaging conditions. Imaging factors include sample-to-detector distance, X-ray energy, CT reconstruction method, phase retrieval algorithm applied to the CT projection images and maximum intensity projection. Observers including breast radiologists and medical imaging experts compared the quality of the reconstructed images with reference images approximating the conventional (absorption) CT. Various radiological image quality attributes in a visual grading analysis design were used for the radiological assessments. Results The results show that the application of the longest achievable sample-to-detector distance (9.31 m), the lowest employed X-ray energy (32 keV), the full phase retrieval, and the maximum intensity projection can significantly improve the radiological quality of the image. Several combinations of imaging variables resulted in images with very high-quality scores. Conclusion The results of the present study will support future experimental and clinical attempts to further optimize this innovative approach to breast cancer imaging.
- Published
- 2018
14. Phase-contrast clinical breast CT: Optimization of imaging setups and reconstruction workflows
- Author
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Fulvio Stacul, Diego Dreossi, Andrew W. Stevenson, Timur E. Gureyev, Darren Lockie, Konstantin Mikhailovitch Pavlov, Christian Dullin, Agostino Accardo, Giuliana Tromba, Markus J. Kitchen, Serena Pacilè, Darren Thompson, Maura Tonutti, Francesco Brun, Fabrizio Zanconati, Sheridan C. Mayo, Jeremy M. C. Brown, Yakov Nesterets, Lang K.,Tingberg A.,Timberg P., Tromba, Giuliana, Pacilè, Serena, Nesterets, Yakov I., Brun, Francesco, Dullin, Christian, Dreossi, Diego, Mayo, Sheridan C., Stevenson, Andrew W., Pavlov, Konstantin M., Kitchen, Markus J., Thompson, Darren, Brown, Jeremy M. C., Lockie, Darren, Tonutti, Maura, Stacul, Fulvio, Zanconati, Fabrizio, Accardo, Agostino, and Gureyev, T. E.
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Engineering ,Phase contrast microscopy ,Breast CT ,Computed tomography ,Mammography ,Phase contrast ,Synchrotron radiation ,X-rays ,Computer Science (all) ,Theoretical Computer Science ,02 engineering and technology ,01 natural sciences ,Imaging phantom ,law.invention ,010309 optics ,X-ray ,law ,0103 physical sciences ,medicine ,Breast ct ,medicine.diagnostic_test ,business.industry ,Phase-contrast imaging ,021001 nanoscience & nanotechnology ,Workflow ,0210 nano-technology ,Nuclear medicine ,business ,Phase retrieval ,Biomedical engineering - Abstract
We present the outcomes of combined feasibility studies carried out at Elettra and Australian Synchrotron to evaluate novel protocols for threedimensional (3D) mammographic phase contrast imaging. A custom designed plastic phantom and some tissue samples have been studied at diverse resolution scales and experimental conditions. Several computed tomography (CT) reconstruction algorithms with different pre-processing and post-processing steps have been considered. Special attention was paid to the effect of phase retrieval on the diagnostic value of the reconstructed images. The images were quantitatively evaluated using objective quality indices in comparison with subjective assessments performed by three experienced radiologists and one pathologist. We show that the propagation-based phase-contrast imaging (PBI) leads to substantial improvement to the contrast-to-noise and to the intrinsic quality of the reconstructed CT images compared with conventional techniques as well as to an important reduction of the delivered doses, thus opening the way to clinical implementations.
- Published
- 2016
15. A feasibility study of X-ray phase-contrast mammographic tomography at the Imaging and Medical beamline of the Australian Synchrotron
- Author
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Jeremy M. C. Brown, Francesco Brun, Darren Thompson, Sheridan C Mayo, Marcus J. Kitchen, Timur E. Gureyev, Giuliana Tromba, Yakov Nesterets, Konstantin Mikhailovitch Pavlov, Darren Lockie, Andrew W. Stevenson, Nesterets, Yakov I., Gureyev, Timur E., Mayo, Sheridan C., Stevenson, Andrew W., Thompson, Darren, Brown, Jeremy M. C., Kitchen, Marcus J., Pavlov, Konstantin M., Lockie, Darren, Brun, Francesco, and Tromba, Giuliana
- Subjects
Nuclear and High Energy Physics ,medicine.medical_specialty ,Materials science ,Breast Neoplasms ,phase contrast ,Sensitivity and Specificity ,Imaging phantom ,X-rays, phase contrast, computed tomography, mammography ,Optics ,Imaging, Three-Dimensional ,X-Ray Diffraction ,X-rays ,medicine ,Medical imaging ,Humans ,Tomography, Optical ,Medical physics ,Australian Synchrotron ,Instrumentation ,Radiation ,Pixel ,business.industry ,Phantoms, Imaging ,Detector ,X-ray ,Reproducibility of Results ,computed tomography ,Equipment Design ,Image Enhancement ,Equipment Failure Analysis ,Beamline ,Feasibility Studies ,Female ,Tomography ,business ,Synchrotrons ,Mammography - Abstract
Results are presented of a recent experiment at the Imaging and Medical beamline of the Australian Synchrotron intended to contribute to the implementation of low-dose high-sensitivity three-dimensional mammographic phase-contrast imaging, initially at synchrotrons and subsequently in hospitals and medical imaging clinics. The effect of such imaging parameters as X-ray energy, source size, detector resolution, sample-to-detector distance, scanning and data processing strategies in the case of propagation-based phase-contrast computed tomography (CT) have been tested, quantified, evaluated and optimized using a plastic phantom simulating relevant breast-tissue characteristics. Analysis of the data collected using a Hamamatsu CMOS Flat Panel Sensor, with a pixel size of 100 µm, revealed the presence of propagation-based phase contrast and demonstrated significant improvement of the quality of phase-contrast CT imaging compared with conventional (absorption-based) CT, at medically acceptable radiation doses.
- Published
- 2015
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