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In conjunction with pandemics, medical image data are growing exponentially. In some countries, hospitals collect biometric data from patients, such as fingerprints, iris, or faces. This data can be used for things like identity verification and security management. However, this medical data can be easily compromised by hackers. In order to prevent illegal tampering with medical images and invasion of privacy, a new texture fusion medical image encryption (TFMIE) algorithm derived from biometric images is proposed, which can encrypt the image using biometric information for storage or transmission. First, the medical image is decomposed into n-bit-planes by bit-plane decomposition. Secondly, a fusion image is generated by a biometric image with a circular local binary pattern and pixel-weighted average method. The fused image is further decomposed into n bit-planes through bit-plane decomposition and performs XOR operation with the original medical image in reverse order. Following the execution of the XOR operation, a new scrambling and diffusion algorithm based on a one-dimensional fractional trigonometric function (1DFTF) chaotic map is employed to form the cipher image. The experimental results show that compared with the existing methods, the average information entropy value of TFMIE is 7.99, and the average values of NPCR and UACI reach 0.9958 and 0.3346, respectively, which have strong key sensitivity, good robustness, and anti-attack ability. The method is lossless and has high transmission efficiency, which can meet the needs of medical big data encryption. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical application value of enhanced computed tomography (CT) image texture parameters combined with serum carcinoembryonic antigen (CEA) and carbohydrate antigen 724 (CA724) in the recurrence and metastasis of esophageal cancer after operation. Methods: 86 patients with esophageal cancer who underwent operation treatment in our hospital from June 2019 to July 2021 were selected. The serum CEA and CA724 levels were detected before operation, and enhanced CT scanning was performed, the image data of the arteriovenous phase were analyzed by texture, and the mean value, median, standard deviation, unevenness, skewness, kurtosis, entropy and other parameters were recorded. The patients with esophageal cancer were followed up for 12 months after operation. According to whether they had recurrence and metastasis, they were divided into recurrence and metastasis group (n=32) and non-recurrence and metastasis group (n=54). The differences of texture parameters of enhanced CT images and serum CEA and CA724 levels in the two groups were compared. Receiver Operating characteristic (ROC) curve was used to analyze the predictive value of enhanced CT image texture parameters combined with serum CEA and CA724 for postoperative recurrence and metastasis of patients with esophageal cancer. Results: The arterial stage entropy in the recurrence and metastasis group was higher than that in the non-recurrence and metastasis group (P<0.05). The inevenness and entropy of venous phase in the recurrence and metastasis group were higher than those in the non-recurrence and metastasis group(P<0.05). The serum CEA and CA724 levels in the recurrence and metastasis group were higher than those in the non-recurrence and metastasis group (P<0.05). ROC curve showed that the combination of serum CEA and CA724 had significantly improved the arterial phase entropy, the venous phase unevenness, the area under the curve (AUC) of the entropy, the sensitivity and the specificity compared with the single application of each index, and the combined application had higher predictive efficiency. Conclusion: The serum CEA and CA724 levels and the increase of the entropy and the inhomogeneity and the arterial phase entropy and the inhomogeneity and the entropy of venous phase are related to the recurrence and metastasis of the postoperative patients with esophageal cancer. The combination of the arterial phase entropy and the inhomogeneity and the entropy of venous phase with the serum CEA and CA724 has of high application value in predicting the recurrence and metastasis of the postoperative patients with esophageal cancer. [ABSTRACT FROM AUTHOR]

• DL reconstructions decrease image noise without modifying FBP image texture. • DL reconstructions improve spatial resolution and detectability as to FBP and IR. • DL reconstructions can further reduce dose with respect to IR. To assess whether a deep learning image reconstruction algorithm (TrueFidelity) can preserve the image texture of conventional filtered back projection (FBP) at reduced dose levels attained by ASIR-V in chest CT. Phantom images were acquired using a clinical chest protocol (7.6 mGy) and two levels of dose reduction (60% and 80%). Images were reconstructed with FBP, ASIR-V (50% and 100% blending) and TrueFidelity (low (DL-L), medium (DL-M) and high (DL-H) strength). Noise (SD), noise power spectrum (NPS) and task-based transfer function (TTF) were calculated. Noise texture was quantitatively compared by computing root-mean-square deviations (RMSD) of NPS with respect to FBP. Four experienced readers performed a contrast-detail evaluation. The dose reducing potential of TrueFidelity compared to ASIR-V was assessed by fitting SD and contrast-detail as a function of dose. DL-M and DL-H reduced noise and NPS area compared to FBP and 50% ASIR-V, at all dose levels. At 7.6 mGy, NPS of ASIR-V 50/100% was shifted towards lower frequencies (f peak = 0.22/0.13 mm−1, RMSD = 0.14/0.38), with respect to FBP (f peak = 0.30 mm−1). Marginal difference was observed for TrueFidelity: f peak = 0.33/0.30/0.30 mm−1 and RMSD = 0.03/0.04/0.07 for L/M/H strength. Values of TTF 50% were independent of DL strength and higher compared to FBP and ASIR-V, at all dose and contrast levels. Contrast-detail was highest for DL-H at all doses. Compared to 50% ASIR-V, DL-H had an estimated dose reducing potential of 50% on average, without impairing noise, texture and detectability. TrueFidelity preserves the image texture of FBP, while outperforming ASIR-V in terms of noise, spatial resolution and detectability at lower doses. [ABSTRACT FROM AUTHOR]

Liver biopsy is considered to be the gold standard for analyzing chronic hepatitis and fibrosis; however, it is an invasive and expensive approach, which is also difficult to standardize. Medical imaging techniques such as ultrasonography, computed tomography (CT), and magnetic resonance imaging are non-invasive and helpful methods to interpret liver texture, and may be good alternatives to needle biopsy. Recently, instead of visual inspection of these images, computer-aided image analysis based approaches have become more popular. In this study, a non-invasive, low-cost and relatively accurate method was developed to determine liver fibrosis stage by analyzing some texture features of liver CT images. In this approach, some suitable regions of interests were selected on CT images and a comprehensive set of texture features were obtained from these regions using different methods, such as Gray Level Co-occurrence matrix (GLCM), Laws’ method, Discrete Wavelet Transform (DWT), and Gabor filters. Afterwards, sequential floating forward selection and exhaustive search methods were used in various combinations for the selection of most discriminating features. Finally, those selected texture features were classified using two methods, namely, Support Vector Machines (SVM) and k -nearest neighbors ( k -NN). The mean classification accuracy in pairwise group comparisons was approximately 95% for both classification methods using only 5 features. Also, performance of our approach in classifying liver fibrosis stage of subjects in the test set into 7 possible stages was investigated. In this case, both SVM and k -NN methods have returned relatively low classification accuracies. Our pairwise group classification results showed that DWT, Gabor, GLCM, and Laws’ texture features were more successful than the others; as such features extracted from these methods were used in the feature fusion process. Fusing features from these better performing families further improved the classification performance. The results show that our approach can be used as a decision support system in especially pairwise fibrosis stage comparisons. [ABSTRACT FROM AUTHOR]

To evaluate the effect of specific nursing intervention in children with mycoplasma pneumonia (MP), a feature extraction algorithm based on gray level co-occurrence matrix (GLCM) was proposed and combined with computed tomography (CT) image texture features. Then, 98 children with MP were rolled into the observation group with 49 cases (specific nursing) and the control group with 49 cases (routine nursing). CT images based on feature extraction algorithm of optimized GLCM were used to examine the children before and after nursing intervention, and the recovery of the two groups of children was discussed. The results showed that the proportion of lung texture increase, rope shadow, ground glass shadow, atelectasis, and pleural effusion in the observation group (24.11%, 3.86%, 8.53%, 15.03%, and 3.74%) was significantly lower than that in the control group (28.53%, 10.23%, 13.34%, 21.15%, and 8.13%) after nursing (P < 0.05). There were no significant differences in the proportion of small patchy shadows, large patchy consolidation shadows, and bronchiectasis between the observation group and the control group (P > 0.05). In the course of nursing intervention, in the observation group, the disappearance time of cough, normal temperature, disappearance time of lung rales, and absorption time of lung shadow (2.15 ± 0.86 days, 4.81 ± 1.14 days, 3.64 ± 0.55 days, and 5.96 ± 0.62 days) were significantly shorter than those in the control group (2.87 ± 0.95 days, 3.95 ± 1.06 days, 4.51 ± 1.02 days, and 8.14 ± 1.35 days) (P < 0.05). After nursing intervention, the proportion of satisfaction and total satisfaction in the experimental group (67.08% and 28.66%) was significantly higher than that in the control group (40.21% and 47.39%), while the proportion of dissatisfaction (4.26%) was significantly lower than that in the control group (12.4%) (P < 0.05). To sum up, specific nursing intervention was more beneficial to improve the progress of characterization recovery and the overall recovery effect of children with MP relative to conventional nursing. CT image based on feature extraction algorithm of optimized GLCM was of good adoption value in the diagnosis and treatment of MP in children. [ABSTRACT FROM AUTHOR]

CT images corresponding to the cross-sections of the patients’ upper torso were analysed. The data set included the healthy class and 3 classes of cases affected by sarcoidosis. It was a state involving only the trachea – Sick(1), a state including trachea and lung parenchyma – Sick(2) and a state involving only lung parenchyma – Sick(3). Based on a fractal analysis and a feature selection by linear stepwise regression, 4 descriptors were obtained, which were later used in the classification process. These were 2 fractal dimensions calculated by the variation and box counting methods, lacunarity calculated also with the box counting method and the intercept parameter calculated using the power spectral density method. Two descriptors were obtained as a result of a gray image analysis, and 2 more were the effect of a binary image analysis. The effectiveness of the descriptors was verified using 8 popular classification methods. In the process of classifier testing, the overall classification accuracy was 90.97%, and the healthy cases were detected with the accuracy of 100%. In turn, the accuracy of recognition of the sick cases was: Sick(1) – 92.50%, Sick(2) – 87.50% and Sick(3) – 90.00%. In the classification process, the best results were obtained with the support vector machine and the naive Bayes classifier. The results of the research have shown the high efficiency of a fractal analysis as a tool for the feature vector extraction in the computer aided diagnosis of sarcoidosis.

Objective. While simulated low-dose CT images and phantom studies cannot fully approximate subjective and objective effects of deep learning (DL) denoising on image quality, live animal models may afford this assessment. This study is to investigate the potential of DL in CT dose reduction on image quality compared to iterative reconstruction (IR). Approach. The upper abdomen of a live 4 year old sheep was scanned on a CT scanner at different exposure levels. Images were reconstructed using FBP and ADMIRE with 5 strengths. A modularized DL network with 5 modules was used for image reconstruction via progressive denoising. Radiomic features were extracted from a region over the liver. Concordance correlation coefficient (CCC) was applied to quantify agreement between any two sets of radiomic features. Coefficient of variation was calculated to measure variation in a radiomic feature series. Structural similarity index (SSIM) was used to measure the similarity between any two images. Diagnostic quality, low-contrast detectability, and image texture were qualitatively evaluated by two radiologists. Pearson correlation coefficient was computed across all dose-reconstruction/denoising combinations. Results. A total of 66 image sets, with 405 radiomic features extracted from each, are analyzed. IR and DL can improve diagnostic quality and low-contrast detectability and similarly modulate image texture features. In terms of SSIM, DL has higher potential in preserving image structure. There is strong correlation between SSIM and radiologists’ evaluations for diagnostic quality (0.559) and low-contrast detectability (0.635) but moderate correlation for texture (0.313). There is moderate correlation between CCC of radiomic features and radiologists’ evaluation for diagnostic quality (0.397), low-contrast detectability (0.417), and texture (0.326), implying that improvement of image features may not relate to improvement of diagnostic quality. Conclusion. DL shows potential to further reduce radiation dose while preserving structural similarity, while IR is favored by radiologists and more predictably alters radiomic features. [ABSTRACT FROM AUTHOR]

Objective: To evaluate image quality and diagnostic confidence improvement using a thin slice and a deep learning image reconstruction (DLIR) in contrast-enhanced abdominal CT. Methods: Forty patients with hepatic lesions in enhanced abdominal CT were retrospectively analyzed. Images in the portal phase were reconstructed at 5 mm and 1.25 mm slice thickness using the 50% adaptive statistical iterative reconstruction (ASIR-V) (ASIR-V50%) and at 1.25 mm using DLIR at medium (DLIR-M) and high (DLIR-H) settings. CT number and standard deviation of the hepatic parenchyma, spleen, portal vein, and subcutaneous fat were measured, and contrast-to-noise ratio (CNR) was calculated. Edge-rise-slope (ERS) was measured on the portal vein to reflect spatial resolution and the CT number skewness on liver parenchyma was calculated to reflect image texture. Two radiologists blindly assessed the overall image quality including subjective noise, image contrast, visibility of small structures using a 5-point scale, and object sharpness and lesion contour using a 4-point scale. Results: For the 1.25-mm images, DLIR significantly reduced image noise, improved CNR and overall subjective image quality compared to ASIR-V50%. Compared to the 5-mm ASIR-V50% images, DLIR images had significantly higher scores in the visibility and contour for small structures and lesions; as well as significantly higher ERS and lower CT number skewness. At a quarter of the signal strength, the 1.25-mm DLIR-H images had a similar subjective noise score as the 5-mm ASIR-V50% images. Conclusion: DLIR significantly reduces image noise and maintains a more natural image texture; image spatial resolution and diagnostic confidence can be improved using thin slice images and DLIR in abdominal CT. Key Points: • DLIR further reduces image noise compared with ASIR-V while maintaining favorable image texture. • In abdominal CT, thinner slice images improve image spatial resolution and small object visualization but suffer from higher image noise. • Thinner slice images combined with DLIR in abdominal CT significantly suppress image noise for detecting low-density lesions while significantly improving image spatial resolution and overall image quality. [ABSTRACT FROM AUTHOR]

Introduction: Chest radiograph and computed tomography (CT) scans can accidentally reveal pulmonary nodules. Malignant and benign pulmonary nodules can be difficult to distinguish without specific imaging features, such as calcification, necrosis, and contrast enhancement. However, these lesions may exhibit different image texture characteristics which cannot be assessed visually. Thus, a computer‐assisted quantitative method like histogram analysis (HA) of Hounsfield unit (HU) values can improve diagnostic accuracy, reducing the need for invasive biopsy. Methods: In this exploratory control study, nonenhanced chest CT images of 20 patients with benign (10) and cancerous (10) lesion were selected retrospectively. The appearances of benign and malignant lesions were very similar in chest CT images, and only pathology report was used to discriminate them. Free hand region of interest (ROI) was inserted inside the lesion for all slices of each lesion. Mean, minimum, maximum, and standard deviations of HU values were recorded and used to make HA. Results: HA showed that the most malignant lesions have a mean HU value between 30 and 50, a maximum HU less than 150, and a minimum HU between −30 and 20. Lesions outside these ranges were mostly benign. Conclusion: Quantitative CT analysis may differentiate malignant from benign lesions without specific malignancy patterns on unenhanced chest CT image. [ABSTRACT FROM AUTHOR]

Objectives: To compare deep learning (True Fidelity, TF) and partial model based Iterative Reconstruction (ASiR-V) algorithm for image texture, low contrast lesion detectability and potential dose reduction.Methods: Anthropomorphic phantoms (mimicking non-overweight and overweight patient), containing lesions of 6 mm in diameter with 20HU contrast, were scanned at five different dose levels (2,6,10,15,20 mGy) on a CT system, using clinical routine protocols for liver lesion detection. Images were reconstructed using ASiR-V 0% (surrogate for FBP), 60 % and TF at low, medium and high strength. Noise texture was characterized by computing a normalized Noise Power Spectrum filtered by an eye filter. The similarity against FBP texture was evaluated using peak frequency difference (PFD) and root mean square deviation (RMSD). Low contrast detectability was assessed using a channelized Hotelling observer and the area under the ROC curve (AUC) was used as figure of merit. Potential dose reduction was calculated to obtain the same AUC for TF and ASiR-V.Results: FBP-like noise texture was more preserved with TF (PFD from -0.043mm-1 to -0.09mm-1, RMSD from 0.12mm-1 to 0.21mm-1) than with ASiR-V (PFD equal to 0.12 mm-1, RMSD equal to 0.53mm-1), resulting in a sharper image. AUC was always higher with TF than ASIR-V. In average, TF compared to ASiR-V, enabled a radiation dose reduction potential of 7%, 25 % and 33 % for low, medium and high strength respectively.Conclusion: Compared to ASIR-V, TF at high strength does not impact noise texture and maintains low contrast liver lesions detectability at significant lower dose. [ABSTRACT FROM AUTHOR]

The objective of this study is to create patient-specific phantoms for computed tomography (CT) that possess accurate densities and exhibit visually realistic image textures. These qualities are crucial for evaluating CT performance in clinical settings. The study builds upon a previously presented 3D printing method (PixelPrint) by incorporating soft tissue and bone structures. We converted patient DICOM images directly into 3D printer instructions using PixelPrint and utilized calcium-doped filament to increase the Hounsfield unit (HU) range. Density was modeled by controlling printing speed according to volumetric filament ratio to emulate attenuation profiles. We designed micro-CT phantoms to demonstrate the reproducibility, and to determine mapping between filament ratios and HU values on clinical CT systems. Patient phantoms based on clinical cervical spine and knee examinations were manufactured and scanned with a clinical spectral CT scanner. The CT images of the patient-based phantom closely resembled original CT images in visual texture and contrast. Micro-CT analysis revealed minimal variations between prints, with an overall deviation of ± 0.8% in filament line spacing and ± 0.022 mm in line width. Measured differences between patient and phantom were less than 12 HU for soft tissue and 15 HU for bone marrow, and 514 HU for cortical bone. The calcium-doped filament accurately represented bony tissue structures across different X-ray energies in spectral CT (RMSE ranging from ± 3 to ± 28 HU, compared to 400 mg/ml hydroxyapatite). In conclusion, this study demonstrated the possibility of extending 3D-printed patient-based phantoms to soft tissue and bone structures while maintaining accurate organ geometry, image texture, and attenuation profiles. [ABSTRACT FROM AUTHOR]

Abstract: The purpose of this phantom study was to investigate the feasibility of dose reduction with hybrid iterative reconstruction, with and without a noise power spectrum (NPS) model, using both quantitative and qualitative evaluations. Standard dose (SD), three‐quarter dose (TQD), and half‐dose (HD) of radiation were used. Images were reconstructed with filtered back projection (FBP), adaptive iterative dose reduction 3D (AIDR 3D) (MILD, STR), and AIDR 3D enhanced (eAIDR 3D) (eMILD, eSTR). An NPS analysis, task‐based modulation transfer function (MTFtask) analysis, and comparisons of low‐contrast detectability and image texture were performed. Although the eAIDR 3D had a higher NPS value in the high‐frequency range and improved image texture and resolution as compared with AIDR 3D at the same radiation dose and iteration levels, it yielded higher noise than AIDR 3D. Additionally, although there was no statistically significant difference between SD‐FBP and the TQD series in the comparison of the mean area under the curve (AUC), the mean AUC was statistically significantly different between SD‐FBP and the HD series. NPS values in the high‐frequency range, 10% MTFtask values, low‐contrast detectability, and image textures of TQD‐eMILD were comparable to those of SD‐FBP. Our findings suggested that using eMILD can reduce the radiation dose by 25%, while potentially maintaining diagnostic performance, spatial resolution, and image texture; this could support selecting the appropriate protocol in a clinical setting. [ABSTRACT FROM AUTHOR]

Objectives: To evaluate image quality and diagnostic performance of carotid dual-energy computed tomography angiography (DECTA) using deep learning image reconstruction (DLIR) compared with images using adaptive statistical iterative reconstruction-Veo (ASIR-V). Methods: Carotid DECTA datasets of 28 consecutive patients were reconstructed at 50 keV using DLIR at low, medium, and high levels (DLIR-L, DLIR-M, and DLIR-H) and 80% ASIR-V algorithms. Mean attenuation, image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) at different levels of arteries were measured and calculated. Image quality for noise and texture, depiction of arteries, and diagnostic performance toward carotid plaques were assessed subjectively by two radiologists. Quantitative and qualitative parameters were compared between the ASIR-V, DLIR-L, DLIR-M, and DLIR-H groups. Results: The image noise at aorta and common carotid artery, SNR, and CNR at all level arteries of DLIR-H images were significantly higher than those of ASIR-V images (p = 0.000–0.040). The quantitative analysis of DLIR-L and DLIR-M showed comparable denoise capability with ASIR-V. The overall image quality (p = 0.000) and image noise (p = 0.000–0.014) were significantly better in the DLIR-M and DLIR-H images. The image texture was improved by DLR at all level compared to ASIR-V images (p = 0.000–0.008). Depictions of head and neck arteries and diagnostic performance were comparable between four groups (p > 0.05). Conclusions: Compared with 80% ASIR-V, we recommend DLIR-H for clinical carotid DECTA reconstruction, which can significantly improve the image quality of carotid DECTA at 50 keV but maintain a desirable diagnostic performance and arterial depiction. [ABSTRACT FROM AUTHOR]

Objective: Evaluate and compare the image quality and acceptance of a full MBIR algorithm to that of an earlier full IR hybrid algorithm and filtered back projection (FBP).Methods: Acquisitions were performed with a 320 detector-row CT scanner with seven different dose levels. Images were reconstructed with three algorithms: FBP, full hybrid iterative reconstruction (HIR), and a full model-based iterative reconstruction algorithm (full MBIR). The sensitometry, spatial resolution, image texture, and low-contrast detectability of these algorithms were compared. Subjective analysis of low-contrast detectability was performed. Ten radiologists answered a questionnaire on image quality and confidence in full MBIR images in clinical practice.Results: The contrast-to-noise ratio of full MBIR was significantly higher than in the other algorithms (p < 0.0015). The spatial resolution was also higher with full MBIR at high frequencies (> 0.3 lp/mm). Full MBIR at low dose levels led to better low-contrast detectability and more inserts being identified with a higher confidence (p < 0.0001). Full MBIR was associated with a change in image texture compared to HIR and FBP. Eighty percent of radiologists judged general appearance and texture of full MBIR images worse than HIR. Moreover, compared with HIR, for 50% of radiologists, the diagnostic confidence on full MBIR images was worse. Questionnaire reliability was considered acceptable (Cronbach alpha 0.7).Conclusion: Compared to conventional iterative reconstruction algorithms, full MBMIR presented a higher image quality and low-contrast detectability and a worse acceptance among radiologists.Key Points: • Full MBIR used led to an overall improvement in image quality compared with FBP and HIR. • Full MBIR leads to image texture change which reduces the confidence in these images among radiologists. • Awareness of the image texture change and improved quality of full MBIR reconstructed images could improve the acceptance of this technique in clinical practice. [ABSTRACT FROM AUTHOR]

Simple Summary: Pediatric osteosarcoma is one of the most aggressive cancers, and predictions of metastasis and chemotherapy response have a significant impact on pediatric patient survival. Radiogenomics, as methods of analyzing gene expression or image texture features, have previously been used for the diagnosis of chemotherapy responses and metastasis and can reveal the current state of cancer. In this study, we aimed to generate a predictive model using gene expression and 18F-FDG PET/CT image texture features in pediatric osteosarcoma in relation to metastasis and chemotherapy response. A predictive model using radiogenomics technology that incorporates both imaging features and gene expression can accurately predict metastasis and chemotherapy responses to improve patient outcomes. Chemotherapy response and metastasis prediction play important roles in the treatment of pediatric osteosarcoma, which is prone to metastasis and has a high mortality rate. This study aimed to estimate the prediction model using gene expression and image texture features. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) images of 52 pediatric osteosarcoma patients were used to estimate the machine learning algorithm. An appropriate algorithm was selected by estimating the machine learning accuracy. 18F-FDG PET/CT images of 21 patients were selected for prediction model development based on simultaneous KI67 and EZRIN expression. The prediction model for chemotherapy response and metastasis was estimated using area under the curve (AUC) maximum image texture features (AUC_max) and gene expression. The machine learning algorithm with the highest test accuracy in chemotherapy response and metastasis was selected using the random forest algorithm. The chemotherapy response and metastasis test accuracy with image texture features was 0.83 and 0.76, respectively. The highest test accuracy and AUC of chemotherapy response with AUC_max, KI67, and EZRIN were estimated to be 0.85 and 0.89, respectively. The highest test accuracy and AUC of metastasis with AUC_max, KI67, and EZRIN were estimated to be 0.85 and 0.8, respectively. The metastasis prediction accuracy increased by 10% using radiogenomics data. [ABSTRACT FROM AUTHOR]

BACKGROUND: The plausibility of image texture analysis to assess X‐ray images of S. oryzae‐infested rice after variable storage days (fresh, 45, 90, 135, 180 and 225 days) was investigated using an X‐ray micro computed tomography instrument. Subsequently, image acquisition, pre‐processing, and the extraction of the image textural features was done using volume graphics VGL 2.2 software. Morphological features (radius, diameter, volume, compactness, sphericity, defect volume, and voids) were extracted from the x, y, and z views of the rice grain and used as inputs for principal component analysis (PCA). RESULTS: Clear grouping was observed between the fresh, 45 and 225‐day‐old S. oryzae‐infested rice grains with a classification accuracy of 88.34%. The voids (884 248.53 μm3) and defect volume distribution (137 428.04 μm3) were found to be the maximum in 225‐day‐old samples. The similarity or the distance indices values between fresh and 255‐day‐old S. oryzae‐infested rice samples were found to be 35 038.08, which resulted in clear discrimination between different storage days in S. oryzae‐infested rice grains. CONCLUSION: This work contributes to the potential use of image texture analysis to aid in distinguishing S. oryzae‐infested rice grains from fresh rice grains. © 2019 Society of Chemical Industry [ABSTRACT FROM AUTHOR]

Background: We assessed and compared the image quality of normal and pathologic structures as well as the image noise in chest computed tomography images using "adaptive statistical iterative reconstruction-V" (ASiR-V) or deep learning reconst ruction "TrueFidelity". Methods: Forty consecutive patients with suspected lung disease were evaluated. The 1.25-mm axial images and 2.0-mm coronal multiplanar images were reconstructed under the following three conditions: (i) ASiR-V, lung kernel with 60% of ASiR-V; (ii) TF-M, standard kernel, image filter (Lung) with TrueFidelity at medium strength; and (iii) TF-H, standard kernel, image filter (Lung) with TrueFidelity at high strength. Two radiologists (readers) independently evaluated the image quality of anatomic structures using a scale ranging from 1 (best) to 5 (worst). In addition, readers ranked their image preference. Objective image noise was measured using a circular region of interest in the lung parenchyma. Subjective image quality scores, total scores for normal and abnormal structures, and lesion detection were compared using Wilcoxon's signedrank test. Objective image quality was compared using Student's paired t-test and Wilcoxon's signed-rank test. The Bonferroni correction was applied to the P value, and significance was assumed only for values of P < 0.016. Results: Both readers rated TF-M and TF-H images significantly better than ASiR-V images in terms of visualization of the centrilobular region in axial images. The preference score of TF-M and TF-H images for reader 1 were better than that of ASiR-V images, and the preference score of TF-H images for reader 2 were significantly better than that of ASiR-V and TF-M images. TF-M images showed significantly lower objective image noise than ASiR-V or TF-H images. Conclusion: TrueFidelity showed better image quality, especially in the centrilobular region, than ASiR-V in subjective and objective evaluations. In addition, the image texture preference for TrueFidelity was better than that for ASiR-V. [ABSTRACT FROM AUTHOR]

Background: Deep learning surpasses many traditional methods for many vision tasks, allowing the transformation of hierarchical features into more abstract, high-level features. Purpose: To evaluate the prognostic value of preoperative computed tomography (CT) image texture features and deep learning self-learning high-throughput features (SHF) on postoperative overall survival in the treatment of patients with colorectal cancer (CRC). Material and Methods: The dataset consisted of 810 enrolled patients with CRC confirmed from 10 November 2011 to 10 February 2018. In contrast, SHF extracted by deep learning with multi-task training mechanism and texture features were extracted from the CT with tumor volume region of interest, respectively, and combined with the Cox proportional hazard (CoxPH) model for initial validation to obtain a RAD score to classify patients into high- and low-risk groups. The SHF stability was further validated in combination with Neural Multi-Task Logistic Regression (N-MTLR) model. The overall recognition ability and accuracy of CoxPH and N-MTLR model were evaluated by C-index and Integrated Brier Score (IBS). Results: SHF had a more significant degree of differentiation than texture features. The result is (SHF vs. texture features: C-index: 0.884 vs. 0.611; IBS: 0.025 vs. 0.073) in the CoxPH model, and (SHF vs. texture features: C-index: 0.861 vs. 0.630; IBS: 0.024 vs. 0.065) in N-MTLR. Conclusion: SHF is superior to texture features and has potential application for the preoperative prediction of the individualized treatment of CRC. [ABSTRACT FROM AUTHOR]

Objectives: To perform a comprehensive within-subject image quality analysis of abdominal CT examinations reconstructed with DLIR and to evaluate diagnostic accuracy compared to the routinely applied adaptive statistical iterative reconstruction (ASiR-V) algorithm. Materials and methods: Oncologic patients were prospectively enrolled and underwent contrast-enhanced CT. Images were reconstructed with DLIR with three intensity levels of reconstruction (high, medium, and low) and ASiR-V at strength levels from 10 to 100% with a 10% interval. Three radiologists characterized the lesions and two readers assessed diagnostic accuracy and calculated signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), figure of merit (FOM), and subjective image quality, the latter with a 5-point Likert scale. Results: Fifty patients (mean age: 70 ± 10 years, 23 men) were enrolled and 130 liver lesions (105 benign lesions, 25 metastases) were identified. DLIR_H achieved the highest SNR and CNR, comparable to ASiR-V 100% (p ≥.051). DLIR_M returned the highest subjective image quality (score: 5; IQR: 4–5; p ≤.001) and significant median increase (29%) in FOM (p <.001). Differences in detection were identified only for lesions ≤ 0.5 cm: 32/33 lesions were detected with DLIR_M and 26 lesions were detected with ASiR-V 50% (p =.031). Lesion accuracy of was 93.8% (95% CI: 88.1, 97.3; 122 of 130 lesions) for DLIR and 87.7% (95% CI: 80.8, 92.8; 114 of 130 lesions) for ASiR-V 50%. Conclusions: DLIR yields superior image quality and provides higher diagnostic accuracy compared to ASiR-V in the assessment of hypovascular liver lesions, in particular for lesions ≤ 0.5 cm. Clinical relevance statement: Deep learning image reconstruction algorithm demonstrates higher diagnostic accuracy compared to iterative reconstruction in the identification of hypovascular liver lesions, especially for lesions ≤ 0.5 cm. Key Points: • Iterative reconstruction algorithm impacts image texture, with negative effects on diagnostic capabilities. • Medium-strength deep learning image reconstruction algorithm outperforms iterative reconstruction in the diagnostic accuracy of ≤ 0.5 cm hypovascular liver lesions (93.9% vs 78.8%), also granting higher objective and subjective image quality. • Deep learning image reconstruction algorithm can be safely implemented in routine abdominal CT protocols in place of iterative reconstruction. [ABSTRACT FROM AUTHOR]

Non-linear properties of iterative reconstruction (IR) algorithms can alter image texture. We evaluated the effect of a model-based IR algorithm (advanced modelled iterative reconstruction; ADMIRE) and dose on computed tomography thorax image quality. Dual-source scanner data were acquired at 20, 45 and 65 reference mAs in 20 patients. Images reconstructed with filtered back projection (FBP) and ADMIRE Strengths 3–5 were assessed independently by six radiologists and analysed using an ordinal logistic regression model. For all image criteria studied, the effects of tube load 20 mAs and all ADMIRE strengths were significant (p  < 0.001) when compared to reference categories 65 mAs and FBP. Increase in tube load from 45 to 65 mAs showed image quality improvement in three of six criteria. Replacing FBP with ADMIRE significantly improves perceived image quality for all criteria studied, potentially permitting a dose reduction of almost 70% without loss in image quality. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the value of the deep learning image reconstruction (DLIR) algorithm (GE Healthcare's TrueFidelity™) in improving the image quality of low-dose computed tomography (LDCT) of the chest. First, we retrospectively extracted raw data of chest LDCT from 50 patients and reconstructed them by using model-based adaptive statistical iterative reconstruction-Veo at 50% (ASIR-V 50%) and DLIR at medium and high strengths (DLIR-M and DLIR-H). Three sets of images were obtained. Next, two radiographers measured the mean CT value/image signal and standard deviation (SD) in Hounsfield units at the region of interest (ROI) and calculated the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). Two radiologists subjectively evaluated the image quality using a 5-point Likert scale. The differences between the groups of data were analyzed through a repeated measures ANOVA or the Friedman test. Last, our result show that the three reconstructions did not differ significantly in signal (p > 0.05) but had significant differences in noise, SNR, and CNR (p < 0.001). The subjective scores significantly differed among the three reconstruction modalities in soft tissue (p < 0.001) but not in lung tissue (p > 0.05). DLIR-H had the best noise reduction ability and improved SNR and CNR without distorting the image texture, followed by DLIR-M and ASIR-V 50%. In summary, DLIR can provide a higher image quality at the same dose, enhancing the physicians' diagnostic confidence and improving the diagnostic efficacy of LDCT for lung cancer screening. [ABSTRACT FROM AUTHOR]

Background: This study investigated the prognostic value of axillary lymph node (ALN) heterogeneity texture features through 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with locally advanced breast cancer (LABC). Methods: We retrospectively analyzed 158 LABC patients with FDG-avid, pathology-proven, metastatic ALN who underwent neoadjuvant chemotherapy (NAC) and curative surgery. Tumor and ALN texture parameters were extracted from pretreatment 18F-FDG PET/CT using Chang-Gung Image Texture Analysis software. The least absolute shrinkage and selection operator regression was performed to select the most significant predictive texture parameters. The predictive impact of texture parameters was evaluated for both progression-free survival and pathologic NAC response. Results: The median follow-up period of 36.8 months and progression of disease (PD) was observed in 36 patients. In the univariate analysis, ALN textures (minimum standardized uptake value (SUV) (p = 0.026), SUV skewness (p = 0.038), SUV bias-corrected Kurtosis (p = 0.034), total lesion glycolysis (p = 0.011)), tumor textures (low-intensity size zone emphasis (p = 0.045), minimum SUV (p = 0.047), and homogeneity (p = 0.041)) were significant texture predictors. On the Cox regression analysis, ALN SUV skewness was an independent texture predictor of PD (p = 0.016, hazard ratio 2.3, 95% confidence interval 1.16–4.58). Conclusions: ALN texture feature from pretreatment 18F-FDG PET/CT is useful for the prediction of LABC progression. [ABSTRACT FROM AUTHOR]

We investigated the performances of two computed tomography (CT) systems produced by the same manufacturers (Somatom Flash and Edge Siemens) with different detector technologies (Ultrafast Ceramic and Stellar) and different generation of iterative reconstruction (IR) algorithms (SAFIRE and ADMIRE). A homemade phantom was scanned and the images were reconstructed with filtered back-projection (FBP) and IR algorithms. In terms of image quality, the performances of the systems were checked using the low-contrast detectability, evaluated by a Channelized Hotelling Observer (CHO), and the noise power spectrum (NPS). The analysis with CHO showed the best performance of Edge respect to Flash system for both FBP and IR algorithms. This better behavior, which reaches 20%, has been ascribed to the Stellar detector. From the NPS analysis, the noise reduction due to Stellar detector was 57%, moreover ADMIRE algorithm preserves a more traditional CT image texture appearance versus SAFIRE due to a lower NPS peak shift. [ABSTRACT FROM AUTHOR]