1. Urinary matrix metalloproteinase-8 and -9 activities in type 2 diabetic subjects: A marker of incipient diabetic nephropathy?
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van der Zijl, Nynke J., Hanemaaijer, Roeland, Tushuizen, Maarten E., Schindhelm, Roger K., Boerop, Jeannette, Rustemeijer, Cees, Bilo, Henk J., Verheijen, Jan H., and Diamant, Michaela
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DIABETIC nephropathies , *METALLOPROTEINASES , *ALBUMINURIA , *PEOPLE with diabetes , *HYPOTHESIS , *COMPARATIVE studies , *DISEASE risk factors - Abstract
Abstract: Matrix metalloproteinases (MMPs) may play a pathophysiological role in the development of diabetic nephropathy (DN). We hypothesized that urinary MMP activity in patients with type 2 diabetes mellitus (T2DM) is related to a decline in renal function. We determined MMP-2, -8 and -9 activity in 24-h urine collections in relation to risk factors for DN in T2DM patients with (UA, n =27) and without albuminuria (NA, n =48) and controls (CO, n =28). MMP-8 and -9 levels were highest in UA patients (P <0.01). Of UA patients, 93% had at least one MMP increased, compared to 78% of NA patients and 46% of CO (P =0.001). Age, diabetes duration, BMI, systolic blood pressure, fasting plasma glucose, HbA1c and renal function were determinants of MMP-8 and -9 (P <0.05). In summary, MMP-8 and -9 are highest in T2DM UA patients. MMP-9, showed the strongest associations with clinical parameters related to DN. [Copyright &y& Elsevier]
- Published
- 2010
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