4 results on '"Fridman, Moshe"'
Search Results
2. Factors associated with caregiver burden among pharmacotherapy-treated children/adolescents with ADHD in the Caregiver Perspective on Pediatric ADHD survey in Europe.
- Author
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Fridman, Moshe, Banaschewski, Tobias, Sikirica, Vanja, Quintero, Javier, Erder, M. Haim, and Chen, Kristina S.
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TREATMENT of attention-deficit hyperactivity disorder , *DRUG therapy , *PSYCHOLOGY of caregivers , *ATTENTION-deficit hyperactivity disorder , *COMORBIDITY , *PSYCHOLOGY - Abstract
Background: Burden on caregivers of children/adolescents with attention-deficit/hyperactivity disorder (ADHD) is multidimensional, but incompletely understood. Objective: To analyze caregiver burden across the concepts of work, social/family life, and parental worry/stress, in relation to selected contributing factors. Methods: The online Caregiver Perspective on Pediatric ADHD survey was fielded in ten European countries. Analysis included children/adolescents (6-17 years) who were receiving/had received ADHD pharmacotherapy in the previous 6 months. Caregivers recorded their child's/adolescent's symptoms "on"/"off" medication (ie, when the caregiver reported that the child/adolescent forgot/chose not to take medication, before the onset of medication effect, or medication worn off). Effects of ADHD severity, comorbidities, and medication adherence on each burden outcome were assessed (multiple regression models). Results: In total, 2,326 caregivers were included (children/adolescents' mean age: 11.5 years, 80% male). Caregivers reported missed/altered work, avoiding social activity, increased parental worry/stress, and strain on family life, despite using ADHD pharmacotherapy. Child/adolescent comorbidities and ADHD severity were significantly related to all burden concepts measured; the strongest comorbidity associations were with altered work (odds ratios [ORs] =1.68 [95% confidence interval {CI} 1.33, 2.12], 1.87 [1.37, 2.54], 3.47 [2.51, 4.78] for 1, 2, 3+ comorbidities, respectively) and planning the day around the child/adolescent (OR =1.42 [95% CI 1.17, 1.72], 1.73 [1.33, 2.15], 2.65 [1.99, 3.53]); the strongest severity associations were: quitting a job (OR =1.41 [95% CI 1.26, 1.59]) and planning a day around the child/adolescent (OR =1.26 [95% CI 1.20, 1.32]). Increased medication adherence was most associated with reducing the caregiver burden for altered work (OR =0.57 [95% CI 0.45, 0.72]), worrying about how they are being perceived as a parent (OR =0.68 [0.56, 0.83]), and avoiding social activity (OR =0.56 [0.45, 0.68]), but not family or stress burden. Conclusion: Burdens related to work, social activity, family life, and parental worry/stress were experienced by the caregivers of children/adolescents with ADHD, despite using ADHD pharmacotherapy. Better understanding of clinical/treatment characteristics most associated with the components of caregiver burden may help improve ADHD management and may ease caregiver burden. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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- View/download PDF
3. Trends in Maternal Morbidity Before and During Pregnancy in California.
- Author
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Fridman, Moshe, Korst, Lisa M., Chow, Jessica, Lawton, Elizabeth, Mitchell, Connie, and Gregory, Kimberly D.
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CHI-squared test , *HEALTH behavior , *LONGITUDINAL method , *NOSOLOGY , *RACE , *RESEARCH funding , *VITAL statistics , *COMORBIDITY , *LOGISTIC regression analysis , *SAMPLE size (Statistics) , *HEALTH equity , *RETROSPECTIVE studies , *PREGNANCY - Abstract
Objectives. We examined trends in maternal comorbidities in California. Methods. We conducted a retrospective cohort study of 1 551 017 California births using state-linked vital statistics and hospital discharge cohort data for 1999, 2002, and 2005. We used International Classification of Diseases, Ninth Revision, Clinical Modification codes to identify the following conditions, some of which were preexisting: maternal hypertension, diabetes, asthma, thyroid disorders, obesity, mental health conditions, substance abuse, and tobacco use. We estimated prevalence rates with hierarchical logistic regression models, adjusting for demographic shifts, and also examined racial/ethnic disparities. Results. The prevalence of these comorbidities increased over time for hospital admissions associated with childbirth, suggesting that pregnant women are getting sicker. Racial/ethnic disparities were also significant. In 2005, maternal hypertension affected more than 10% of all births to non-Hispanic Black mothers; maternal diabetes affected nearly 10% of births to Asian/Pacific Islander mothers (10% and 43% increases, respectively, since 1999). Chronic hypertension, diabetes, obesity, mental health conditions, and tobacco use among Native American women showed the largest increases. Conclusions. The prevalence of maternal comorbidities before and during pregnancy has risen substantially in California and demonstrates racial/ethnic disparity independent of demographic shifts. [ABSTRACT FROM AUTHOR]
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- 2014
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4. Memantine Discontinuation and the Health Status of Nursing Home Residents With Alzheimer's Disease
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Fillit, Howard, Hofbauer, Robert K., Setyawan, Juliana, Tourkodimitris, Stavros, Fridman, Moshe, Pejović, Vojislav, Miller, Michael L., Erder, M. Haim, and Lyketsos, Constantine
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AGGRESSION (Psychology) , *ALZHEIMER'S disease , *AMANTADINE , *ANALYSIS of variance , *COMBINATION drug therapy , *CHI-squared test , *COGNITION , *COMPARATIVE studies , *STATISTICAL correlation , *FACTOR analysis , *HEALTH status indicators , *LENGTH of stay in hospitals , *NEUROPSYCHOLOGICAL tests , *EVALUATION of medical care , *NURSING assessment , *NURSING home patients , *NURSING care facilities , *HEALTH outcome assessment , *RESEARCH funding , *SCALE analysis (Psychology) , *T-test (Statistics) , *WEIGHT loss , *COMORBIDITY , *LOGISTIC regression analysis , *AGITATION (Psychology) , *ACTIVITIES of daily living , *QUANTITATIVE research , *SCALE items , *TREATMENT effectiveness , *RETROSPECTIVE studies , *TREATMENT duration , *SYMPTOMS , *THERAPEUTICS - Abstract
Objective: To estimate the effect of memantine discontinuation for a nonmedical reason (eg, formulary restriction or family decision) on the health status of nursing home (NH) residents with Alzheimer's disease (AD). Design: Retrospective chart review. Setting: NHs (n = 113) in the United States. Participants: Residents (minimum stay of 90 days) with AD, continuously treated with memantine (MC: n = 273) or discontinued for 60 days or longer (MD: n = 248). The subset of patients who discontinued for a nonmedical reason (MD-N: n = 163) was also analyzed, as was the subset of patients in groups MC and MD-N whose doses of concomitant medications remained stable (MCs: n = 185; MD-Ns: n = 70). Measurements: Thirty-one common geriatric and AD symptoms from NH charts were scored based on their emergence or resolution (+1 or –1 points, respectively), worsening or improvement (+0.5 or –0.5 points, respectively), or absence of change (0 points), compared with the baseline period (the first 30 days analyzed in the charts, during which all residents received memantine treatment). Patients' weight change was also captured. Results: Compared with continuous treatment, memantine discontinuation was associated with a significant increase in the Total AD Symptom Change Score (ie, worsening) in all comparison pairs (MC versus MD, MC versus MD-N, and MCs versus MD-Ns: P < .001 for all). The symptoms showing greatest worsening aggregated into two factors: cognition and mood. Conclusion: Memantine discontinuation in NH residents with AD may be associated with declining health status, and should be considered with care. A randomized, placebo-controlled trial of treatment discontinuation is merited. [Copyright &y& Elsevier]
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- 2010
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