1. Serious community-acquired neonatal infections in rural Southeast Asia (Bohol Island, Philippines).
- Author
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Quiambao BP, Simoes EA, Ladesma EA, Gozum LS, Lupisan SP, Sombrero LT, Romano V, and Ruutu PJ
- Subjects
- Age Distribution, Female, Humans, Infant, Newborn, Logistic Models, Male, Philippines epidemiology, Risk Factors, Community-Acquired Infections epidemiology, Gram-Negative Bacterial Infections epidemiology
- Abstract
Objective: To determine the bacterial etiology, clinical presentation and risk factors for outcome of serious community-acquired infections in young infants., Study Design: Infants younger than 60 days, admitted for severe pneumonia or suspected sepsis/meningitis were prospectively evaluated using complete blood count, blood culture, chest radiograph, cerebrospinal fluid (CSF) culture in suspected meningitis. chi2 or Fisher's exact test and stepwise logistic regression were used for analysis., Results: Thirty-four of 767 enrolled infants had a positive blood or CSF culture. Gram-negative bacteria were more frequent than Gram positive: overall (P=0.004), in those below 7 days of age (P=0.002) and among home deliveries (P=0.012). Case fatality rates were higher among infants below 1 week old (OR 4.14, P<0.001), those with dense (OR 2.92, P<0.001) or diffuse radiographic infiltrates (OR 2.79, P=0.003)., Conclusions: Gram-negative enteric bacteria are the predominant causes of community-acquired infections in Filipino infants below 2 months old. Age below 7 days and radiographic pneumonia predicted death.
- Published
- 2007
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