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Introduction: Breast cancer affects women around the world. Communication is essential for managing and treating breast cancer, especially in the breast imaging department. By communicating effectively, mammographers can help to alleviate the fear and burden that breast cancer brings to the lives of affected women. In this study, we explored and described the role of communication between mammographers and post-mastectomy patients in the Limpopo province of South Africa., Methods: This was a qualitative exploratory, descriptive study. Individual in-depth interviews were conducted with patients who underwent mastectomy as well as mammographers in selected healthcare institutions. Due to the different languages used in Limpopo, the researcher had this questionnaire for patients translated in Sepedi. Participants were purposively sampled. Data collection took approximately two months. Summative content analysis was used to analyse the data., Results: Eleven mammographers and 36 patients were interviewed. Three themes emerged from the data collected. Mammographers highlighted the importance of being accommodative, supportive, and sympathetic towards patients. Mammographers made every effort to maintain a good communication path and understanding with their patients. The patients had high admiration for the work and support of mammographers and perceived mammographers as healthcare providers who were trustworthy and held them in high regard., Conclusion: Communication is key in ensuring cooperation between mammographers and patients. Additionally, the mode of communication, including the language should be considered. It is important that patients receive information in languages they are comfortable in. It will help patients understand the proceedings of the examination for which they have been booked for as well as the need for follow-up. Training related to communication for mammographers and possibly the addition of more South African languages as an extra course/module to allow communication with patients to be well carried out., Implications for Practice: The study contributes to a growing body of knowledge within the training of mammographers as well as the implementation of role extension for mammographers., (Copyright © 2024. Published by Elsevier Ltd.)