1. mRNA Vaccination: An Outlook on Innate Sensing and Adaptive Immune Responses.
- Author
-
Shoja Doost, Janan, Fazel, Fatemeh, Boodhoo, Nitish, and Sharif, Shayan
- Subjects
- *
COVID-19 pandemic , *COMMUNICABLE diseases , *MESSENGER RNA , *IMMUNE response , *VACCINATION - Abstract
Vaccination has led to significant dismantling of infectious diseases worldwide. Since the dawn of the SARS-CoV-2 pandemic, there has been increased popularity in the usage and study of the mRNA vaccine platform. Here, we highlight fundamental knowledge on mRNA vaccine pharmacology, followed by the immunity conferred by innate sensing and adaptive responses resulting from exposure to the mRNA vaccine construct and encapsulation materials. A better understanding of these immune mechanisms will shed light on further improvements in mRNA vaccine design, aiming to improve efficiency and optimize immune responses upon inoculation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF