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Start Over Author "Scudo, G" Topic colorectal neoplasms
4 results on '"Scudo, G"'

1. One stage or two stage treatment of colorectal cancer associated to abdominal aortic aneurysm: morbidity and mortality.

Author

Minicozzi A, Veraldi GF, Sboarina A, Lombardo F, Osmani H, Scudo G, Passeri V, Bencivenga M, and Cordiano C

Subjects
Aortic Aneurysm, Abdominal mortality, Colorectal Neoplasms mortality, Digestive System Surgical Procedures adverse effects, Digestive System Surgical Procedures methods, Humans, Postoperative Complications epidemiology, Postoperative Complications etiology, Vascular Surgical Procedures adverse effects, Vascular Surgical Procedures methods, Aortic Aneurysm, Abdominal complications, Aortic Aneurysm, Abdominal surgery, Colorectal Neoplasms complications, Colorectal Neoplasms surgery
Abstract

The coexistence of colorectal cancer and abdominal aortic aneurysm has been observed with increasing frequency, raising several questions about therapeutic and surgical strategies for management of both diseases. This study has reviewed 440 cases (359 cases analyzed) of colorectal cancer associated with abdominal aortic aneurysm recovered in the literature from year 1987 to 2010. In 120 cases, patients were treated in one stage; in 239 cases, they were treated in two stages. The treatment in two stages was associated with a morbidity of 26.4%, with a mortality of 5% and prosthetic infection of 0.8%. The treatment in one stage had rates of complications and mortality of 13.3% and 4.2% respectively and no cases of prosthetic infection. Analysis of the literature shows that the treatment in two stages exposes patients to a higher risk of complications and prosthetic infection.

Published
2012

2. Real-time polymerase chain reaction quantification of free DNA in serum of patients with polyps and colorectal cancers.

Author

Danese E, Montagnana M, Minicozzi AM, De Matteis G, Scudo G, Salvagno GL, Cordiano C, Lippi G, and Guidi GC

Subjects
Adenomatous Polyps blood, Adenomatous Polyps diagnosis, Biomarkers, Tumor blood, Case-Control Studies, Colorectal Neoplasms diagnosis, Female, Humans, Intestinal Polyps diagnosis, Male, Middle Aged, Time Factors, Colorectal Neoplasms blood, DNA blood, DNA genetics, Intestinal Polyps blood, Polymerase Chain Reaction methods
Abstract

Background: Colorectal cancer (CRC) is one of the most frequent causes of cancer related deaths worldwide. Recently, the use of cell-free DNA as diagnostic tools to identify cancer has been investigated. The aim of this work was to assess whether circulating DNA could be considered a useful marker for detection of early stage CRC and polyps., Methods: A total of 118 patients with CRC were included in the study along with 49 patients with colorectal polyps and 26 control subjects. Cell-free DNA was quantified using a real-time TaqMan-polymerase chain reaction assay. Non-parametric tests (Mann-Whitney test and Spearman correlation) were utilized for statistical analysis., Results: Serum DNA concentrations were significantly higher in CRC patients and patients with polyps (median value 105.0 ng/mL and 40.0 ng/mL) compared with controls (median value 14.0 ng/mL; p<0.05). Although carcinoembryonic antigen was above the cut-off in only 13/66 (19.7%) patients with early stage CRC, serum free DNA showed values above the threshold identified using receiver operator characteristic (ROC) curve analysis in 53/66 (80.3%) patients., Conclusions: Our data confirm that serum DNA concentrations are significantly increased in CRC patients with early stage disease and in patients with polyps. This marker might be useful for identifying high-risk individuals.

Published
2010
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3. Retrospective multicenter study of post-operative stenosis after stapled colorectal anastomosis

Author

Sartori A, De Luca M, Fiscon V, Frego M, Vigna S, Mazzeo A, Coco D, Agresta F, Finotti E, Antoniutti M, Carnio S, Elio A, Brunelli M, Ruffo G, Bertocchi E, Parini D, Losacco L, Poli F, Santoro G, Massani M, Ruffolo C, Cian E, Zanatta L, Genna M, Ballarin A, Rebonato M, Fontana M, Moretto G, Impellizzeri H, Merenda R, Margani G, Merigliano S, Baldan N, Ubiali P, Braini A, Balani A, Kosuta M, Infantino A, Giacomel G, Armatura G, Patauner S, de Manzini N, Palmisano S, Sorrentino M, Brizzolari M, Belluco C, Olivieri M, Lauro E, Scudo G, Valduga P, Brolese A, Pignata G, Andreucetti J, Caruso A, Zappalà F, Portale G ., Sartori, A, De Luca, M, Fiscon, V, Frego, M, Vigna, S, Mazzeo, A, Coco, D, Agresta, F, Finotti, E, Antoniutti, M, Carnio, S, Elio, A, Brunelli, M, Ruffo, G, Bertocchi, E, Parini, D, Losacco, L, Poli, F, Santoro, G, Massani, M, Ruffolo, C, Cian, E, Zanatta, L, Genna, M, Ballarin, A, Rebonato, M, Fontana, M, Moretto, G, Impellizzeri, H, Merenda, R, Margani, G, Merigliano, S, Baldan, N, Ubiali, P, Braini, A, Balani, A, Kosuta, M, Infantino, A, Giacomel, G, Armatura, G, Patauner, S, de Manzini, N, Palmisano, S, Sorrentino, M, Brizzolari, M, Belluco, C, Olivieri, M, Lauro, E, Scudo, G, Valduga, P, Brolese, A, Pignata, G, Andreucetti, J, Caruso, A, Zappalà, F, and Portale G, .

Subjects
Male, medicine.medical_specialty, Colorectal anastomosis, Constriction, Pathologic, Anastomosis, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Risk Factors, Surgical Stapling, Prevalence, medicine, Humans, Colorectal anastomosi, Retrospective Studies, Stenosis, business.industry, Stapled anastomosis, Anastomosis, Surgical, Retrospective cohort study, Endoscopic dilatation, medicine.disease, Colorectal surgery, Surgery, Italy, Multicenter study, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business, Complication, Stapled anastomosi
Abstract

Anastomotic stenosis after colorectal surgery is usually considered low-rate complication and often is under-reported in most studies. Few data are available on management strategies. The aim of the study was to assess the prevalence of stenosis after stapled colorectal anastomosis, performed either in elective or emergent setting, for benign or malignant disease, and to evaluate treatment profiles. This retrospective study was a survey conducted in a large Italian North-Eastern area including three regions (Triveneto), over a 12-month period (January–December 2015). Patients’ characteristics and surgical technique details were recorded, along with data on the prevalence of stenosis and its treatment. Patients with mid or low rectal resection and/or neoadjuvant chemo-radio therapy and/or diverting stoma were excluded. The study was promoted by the Italian Association of Hospital Surgeons (ACOI) and the Society of Surgeons of the Triveneto Region. Twenty-eight surgical units were enrolled in the survey, accounting for over 1400 patients studied. Fifty percent of the units performed laparoscopically > 70% of the colorectal resections and 7.5% of the procedures were emergent. Less than 60% of the units planned regular endoscopic follow-up after colorectal resection. Anastomotic stricture was recorded in 2% of the patients; 88% of the stenoses were diagnosed within 6 months from surgery. Only one anastomotic stricture required re-do surgery. The CANSAS study confirms that colorectal anastomotic stenosis is low-rate—but still present—complication. Treatment strategies vary according to surgeons’ and endoscopists’ preferences. Commonly endoscopic dilatation is preferred, but re-do surgery is required in some cases.

Published
2019

4. One stage or two stage treatment of colorectal cancer associated to abdominal aortic aneurysm: Morbidity and mortality

Author

Minicozzi, A., Gian Franco Veraldi, Sboarina, A., Lombardo, F., Osmani, H., Scudo, G., Passeri, V., Bencivenga, M., and Cordiano, C.

Subjects
Postoperative Complications, Endovascular procedures, Colorectal neoplasms, Abdominal aortic aneurysm, Humans, Colorectal Neoplasms, Vascular Surgical Procedures, Digestive System Surgical Procedures, Aortic Aneurysm, Abdominal
Abstract

The coexistence of colorectal cancer and abdominal aortic aneurysm has been observed with increasing frequency, raising several questions about therapeutic and surgical strategies for management of both diseases. This study has reviewed 440 cases (359 cases analyzed) of colorectal cancer associated with abdominal aortic aneurysm recovered in the literature from year 1987 to 2010. In 120 cases, patients were treated in one stage; in 239 cases, they were treated in two stages. The treatment in two stages was associated with a morbidity of 26.4%, with a mortality of 5% and prosthetic infection of 0.8%. The treatment in one stage had rates of complications and mortality of 13.3% and 4.2% respectively and no cases of prosthetic infection. Analysis of the literature shows that the treatment in two stages exposes patients to a higher risk of complications and prosthetic infection.

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