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Background. Colorectal cancer (CRC) is a malignant tumor of the large intestine (colon and rectum) with rising frequency worldwide, and a major global public health concern. With approximately 608,000 deaths attributed to it worldwide, CRC accounts for 8% of all cancer deaths, and is numerically the fourth common cause of cancer deaths (OMS). The prevalence of CRC is estimated at 6.3/100,000 per year in Tunisia with comparable incidence in males and females. The polymorphism (-1082) A/G gene promoter that encodes IL-10 has been extensively studied for its involvement in the physiopathology of various diseases such as the development of inflammatory bowel disease as well as in some types of cancer including CCR. Aim. In the present work, we conducted a case-control study to investigate the involvement of IL-10 serum level and IL-10-1082 A>G polymorphism in the modulation of CRC risk. [ABSTRACT FROM AUTHOR]