1. Periostin as a promising target of therapeutical intervention for colorectal cancer
- Author
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Li Na Song, Ling Xia Li, Qing Hong Shi, Ling Fang, Li Sun, Hai Feng Zhao, Ning Liu, Hong Jun Li, and Cheng Yan He
- Subjects
Colorectal cancer ,Periostin ,siRNA ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The expression of periostin in the tissue of colorectal cancer patients and its correlation with clinical features were studied. Periostin expression was ~4 fold up-regulated in cancer tissues compared to adjacent non-cancerous tissues. Serum levels of periostin in patients were significantly elevated to 32.6 ± 10.8 ng/mL vs 20.4 ± 11.1 ng/mL in healthy volunteers. Higher preoperative serum periostin levels in patients were closely related to advanced-stage disease (stage III/IV), distant and lymph nodes metastasis. High level of periostin expression was detected in the SW480 human colon carcinoma cells, and could be down-regulated by small interfering RNAs (siRNA). The siRNA-mediated knockdown of periostin arrested the cell cycle at G0/G1 phase and induced apoptotic cell death in the SW480 cells. In conclusion, periostin is a promising prognostic and therapeutic target for colorectal cancer.
- Published
- 2014