1. Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study.
- Author
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Sui, Qiaoqi, Zheng, Jian, Liu, Dingxin, Peng, Jianhong, Ou, Qingjian, Tang, Jinghua, Li, Yuan, Kong, Lingheng, Jiang, Wu, Xiao, Binyi, Chao, Xue, Pan, Zhizhong, Zhang, Huizhong, and Ding, Pei-Rong
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LIVER , *COLON cancer , *RETROSPECTIVE studies , *PROGNOSIS , *PROTEINS - Abstract
Background: It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear.Methods: CRC cases after resection of liver oligometastases were enrolled in Sun Yat-Sen University Cancer Center with intact clinical data. Serum DKK1 was detected by ELISA assay. Immunofluorescent staining examination for CD3 and CD8 in slices were also conducted.Results: Among 65 patients included, the recurrence-free survival (RFS) and overall survival (OS) were significantly better in the low serum DKK1 group (RFS: P = 0.021; OS: P = 0.043). DKK1 was overexpressed in stage IV CRC patients in TCGA data. The number of CD8+ tumor-infiltrating lymphocytes (TILs) in invasive margin of CRC liver oligometastases was significantly higher in low serum DKK1 group (P = 0.042).Conclusion: Elevated serum DKK1 level was associated with poorer RFS and OS, and less CD8+ TILs in invasive margin in CRC liver oligometastases. DKK1 might serve as a supplementalprognostic factor for clinical risk score and a potential target for immunotherapy. [ABSTRACT FROM AUTHOR]- Published
- 2019
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